Description : Which analgesic-antiinflammatory drug is more appropriate in musculo-skeletal disorder where pain is more prominent than inflammation: A. Ibuprofen B. Piroxicam C. Indomethacin D. Nimesulide
Last Answer : A. Ibuprofen
Description : The following analgesic lacks antiinflammatory action: A. Paracetamol B. Ibuprofen C. Diclofenac sodium D. Piroxicam
Last Answer : A. Paracetamol
Description : A 45-year-old surgeon has developed symmetric early morning stiffness in her hands. She wishes to take a nonsteroidal anti-inflammatory drug to relieve these symptoms and wants to avoid gastrointestinal side ... appropriate? (a) Aspirin (b) Celecoxib (c) Ibuprofen (d) Indomethacin (e) Piroxicam
Last Answer : Ans: B
Description : Which of the following is an irreversible inhibitor of cyclooxygenase: A. Aspirin B. Phenylbutazone C. Indomethacin D. Piroxicam
Last Answer : A. Aspirin
Description : Which of the following is an efficacious antiinflammatory drug but a relatively weak inhibitor of cyclooxygenase: A. Nimesulide B. Paracetamol C. Ketoprofen D. Indomethacin
Last Answer : A. Nimesulide
Description : For a patient of peptic ulcer, the safest nonopioid analgesic is: A. Celecoxib B. Diclofenac sodium C. Paracetamol D. Ibuprofen
Last Answer : C. Paracetamol
Description : Which of the following non-opioid analgesics is a prodrug? (A) Piroxicam (B) Celecoxib (C)Nabumetone (D) Ketorolac
Last Answer : (C)Nabumetone
Description : Choose the correct statement about nefopam: A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B. It is an orally active opioid analgesic C. It is an analgesic with potent antiinflammatory activity D. It is a preferential COX-2 inhibitor
Last Answer : A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis
Description : Choose the action for which the dose of aspirin required is the lowest: A. Analgesic B. Antipyretic C. Antiinflammatory D. Antiplatelet aggregatory
Last Answer : D. Antiplatelet aggregatory
Description : The plasma half life of aspirin (along with salicylic acid released from it): A. Remains constant irrespective of dose B. Is longer for antiinflammatory doses compared to that for analgesic ... for antiinflammatory doses compared to that for analgesic dose D. Can be shortened by acidifying urine
Last Answer : B. Is longer for antiinflammatory doses compared to that for analgesic dose
Description : A newborn was diagnosed as having a congenital abnormality that resulted in transposition of her great arteries. While preparing the infant for surgery, the medical team needed to keep the ductus arteriosus ... by infusing (a) Cortisol (b) Indomethacin (c) Ketorolac (d) Misoprostol (e) Tacrolimus
Last Answer : Ans: D
Description : Instead of being effective in hyperuricaemia following drug is contradictred in the treatment of gout (a) Indomethacin (b) Diclofenac (c) Piroxicam (d) Aspirin
Description : Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam
Last Answer : Ans: A
Description : Which of the following analgesics itself frequently causes headache as a side effect: A. Indomethacin B. Mephenamic acid C. Piroxicam D. Metamizol
Last Answer : A. Indomethacin
Description : The patient taking the following non-steroidal antiinflammatory drug should be cautioned not to drive motor vehicle: A. Celecoxib B. Indomethacin C. Naproxen D. Diclofenac sodium
Last Answer : B. Indomethacin
Description : Select the drug which inhibits cyclooxygenase in the brain but not at peripheral sites of inflammation: A. Nimesulide B. Paracetamol C. Ketorolac D. Mephenamic acid
Last Answer : B. Paracetamol
Description : Probenecid has the following action(s): A. Uricosuric B. Analgesic C. Antiinflammatory D. Both ‘A’ and ‘C’
Last Answer : A. Uricosuric
Description : Select the drug which is neither analgesic, nor antiinflammatory, nor uricosuric, but is highly efficacious in acute gout: A. Prednisolone B. Colchicine C. Naproxen D. Sulfinpyrazone
Last Answer : B. Colchicine
Description : Phenylbutazone should be used only in patients not responding to other nonsteroidal antiinflammatory drugs (NSAIDs) because: A. It has lower antiinflammatory efficacy than other NSAIDs B. It has potential ... It has weak analgesic action D. It alters the protein binding and metabolism of many drugs
Last Answer : B. It has potential to cause agranulocytosis
Description : Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they: A. Are antiinflammatory but not analgesic B. Donot bring down fever C. Have no renal effects D. Do not inhibit platelet aggregation
Last Answer : D. Do not inhibit platelet aggregation
Description : Renal excretion of lithium is reduced by: A. Furosemide B. Hydrochlorothiazide C. Indomethacin D. All of the above
Last Answer : D. All of the above
Description : Which of the following drugs attenuates the antihypertensive action of β-blockers: A. Cimetidine B. Indomethacin C. Chlorpromazine D. Imipramine
Description : Interaction between the following pair of drugs can be avoided by making suitable adjustments: A. Levodopa and metoclopramide B. Furosemide and indomethacin C. Tetracyclines and ferrous sulfate D. Clonidine and chlorpromazine
Last Answer : C. Tetracyclines and ferrous sulfate
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues
Last Answer : B. It is inducible
Description : Which of the following drugs attenuates the antihypertensive action of β -blockers: A. Cimetidine B. Indomethacin C. Chlorpromazine D. Imipramine
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that: A. They catalyse different pathways in prostanoid biosynthesis B. COX-1 is inhibited by aspirin but not COX-2 C. COX-2 is inhibited by ibuprofen but not COX-1 D. COX-1 is constitutive while COX-2 is largely
Last Answer : D. COX-1 is constitutive while COX-2 is largely
Description : What is true of nimesulide: A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B. It is preferred for long-term use in rheumatoid arthritis C. It is contraindicated in aspirin intolerant asthma patients D. All of the above
Last Answer : A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition
Description : The following is true of clofazimine except: A. It is cidal to Mycobacterium leprae B. It has additional antiinflammatory property C. It has a very long elimination half life D. It discolours skin and sweat
Last Answer : A. It is cidal to Mycobacterium leprae
Description : The following is/are true of mesalazine: A. It exerts mainly local antiinflammatory action in the lower gut B. It is a broad spectrum antidiarrhoeal drug C. It can be administered as a retention enema D. Both 'A' and 'C
Last Answer : D. Both 'A' and 'C
Description : The following statement is true about misoprostol: A. It relieves peptic ulcer pain, but does not promote ulcer healing B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding ... side effects than H2 blockers D. It is the most effective drug for preventing ulcer relapse
Last Answer : B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding to H2 blockers
Description : Antiatherosclerotic effect of which class of hypolipidemic drugs may involve additional mechanisms like improved endothelial function, reduced LDL oxidation and antiinflammatory property: A. Bile acid sequestrant resins B. Statins C. Fibrates D. Nicotinic acid
Last Answer : B. Statins
Description : Nonsteroidal antiinflammatory drugs reduce the diuretic action of furosemide by: A. Preventing prostaglandin mediated intrarenal haemodynamic actions B. Blocking the action in ascending limb of loop ... C. Enhancing salt and water reabsorption in distal tubule D. Increasing aldosterone secretion
Last Answer : A. Preventing prostaglandin mediated intrarenal haemodynamic actions
Description : Advantages of angiotensin converting enzyme inhibitors as antihypertensive include the following except: A. They tend to reverse left ventricular hypertrophy B. Their efficacy is not reduced by nonsteroidal ... . They do not worsen blood lipid profile D. They do not impair work performance
Last Answer : B. Their efficacy is not reduced by nonsteroidal antiinflammatory drugs
Description : The most important mechanism of antiinflammatory action of glucocorticoids is: A. Inhibition of lysosomal enzymes B. Restriction of recruitment of inflammatory cells at the site of inflammation C. Antagonism of action of interleukins D. Suppression of complement function
Last Answer : B. Restriction of recruitment of inflammatory cells at the site of inflammation
Description : Corticosteroids exert antiinflammatory action by inhibiting the following enzyme: A. Cyclooxygenase B. Lipoxygenase C. Phospholipase-A D. Phosphodiesterase
Last Answer : C. Phospholipase-A
Description : Budesonide is a: A. Nonsteroidal antiinflammatory drug B. High ceiling diuretic C. Inhaled corticosteroid for asthma D. Contraceptive
Last Answer : C. Inhaled corticosteroid for asthma
Description : Select the drug that is neither bronchodilator nor antiinflammatory, but has antihistaminic and mast cell stabilizing activity: A. Sodium cromoglycate B. Ketotifen C. Beclomethasone dipropionate D. Chlorpheniramine
Last Answer : B. Ketotifen
Description : Sulfinpyrazone has the following action(s): A. Antiplatelet aggregatory B. Uricosuric C. Antiinflammatory D. Both ‘A’ and ‘B’
Last Answer : D. Both ‘A’ and ‘B’
Description : The following nonsteroidal antiinflammatory drug is a preferential cyclooxygenase-2 (COX-2) inhibitor: A. Tenoxicam B. Meloxicam C. Diclofenac sod. D. Ketoprofen
Last Answer : B. Meloxicam
Description : The constellation of adverse effects associated with nonsteroidal antiinflammatory drugs include the following except: A. Sedation B. Gastric irritation C. Fluid retention D. Rashes
Last Answer : A. Sedation
Description : Choose the correct statement about nonsteroidal antiinflammatory drugs (NSAIDs): A. NSAIDs attenuate hypoglycaemic action of sulfonylureas B. NSAIDs potentiate antihypertensive action of ACE inhibitors C. ... D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding
Last Answer : D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding
Description : Antiinflammatory dose of aspirin given to diabetics is prone to cause: A. Hyperglycaemia B. Hypoglycaemia C. Ketoacidosis D. Alkalosis
Last Answer : B. Hypoglycaemia
Description : Metabolic effects that generally attend antiinflammatory doses of aspirin include the following except: A. Increased CO2 production B. Hepatic glycogen depletion C. Metabolic acidosis D. Compensated respiratory alkalosis
Last Answer : C. Metabolic acidosis
Description : Choose the correct statement about nonopioid analgesics: A. All have antiinflammatory property B. All lack dependence producing liability C. All act exclusively at peripheral pain mechanisms D. All inhibit prostaglandin synthesis
Last Answer : B. All lack dependence producing liability
Description : The nonsteroidal antiinflammatory drugs are more effective in migraine: A. Without aura B. With aura C. Than ergotamine D. When combined with propranolol
Last Answer : A. Without aura
Description : The following is true of buprenorphine: A. It is an agonist-antagonist type of opioid analgesic B. Its subjective effects are different from those of morphine C. Naloxone is largely ineffective in reversing its effects D. It produces mydriasis
Last Answer : C. Naloxone is largely ineffective in reversing its effects
Description : Pentazocine differs from morphine in that: A. It is inactive by the oral route B. It does not produce physical dependence C. It has a lower ceiling of analgesic effect D. Its action is not blocked by naloxone
Last Answer : C. It has a lower ceiling of analgesic effec
Description : Select the opioid analgesic which acts primarily through κ (kappa) opioid receptor: A. Pentazocine B. Methadone C. Buprenorphine D. Pethidine
Last Answer : A. Pentazocine
Description : Which of the following is an agonist-antagonist type of opioid analgesic: A. Pethidine B. Pentazocine C. Fentanyl D. Buprenorphine
Last Answer : B. Pentazocine
Description : Nalorphine is nearly equipotent analgesic as morphine, but is not used clinically as an analgesic because: A. It causes more marked respiratory depression B. It has higher abuse potential C. It antagonises the action of morphine D. It produces prominent dysphoric effects
Last Answer : D. It produces prominent dysphoric effects