I'm assuming you realize it's impossible to really answer this question, as it is such an individual experience. And for the record, not all women worry about their "clock." But in general, I would say it can start around 24 and get louder and louder, reaching it's peak around 30-35. By 40, if there's no conrete baby-making plans, I'd say a woman would probably start to give up on the idea of childbirth.