answer:Your answer is no – at least not until you’ve taken them for the first time together under medical supervision. The drugs you’re taking are sometimes safely prescribed to people, but should only be prescribed after a doctor sees how you react to all three. The reason being: They’re all sedatives and some people can’t handle all three together, and some can. Did your prescribing doctor know, at the time of your prescription for Percocet and Skelaxin, that you had previously been prescribed Ativan? I was prescribed 1 mg of Ativan (otherwise known as Lorazepam) when I was having pretty bad heart palpitations – and I absolutely cannot imagine taking it with any other kind of sedative. 1 mg knocked me on my ass and also gave me crystal clear hallucinations every time I closed my eyes. You’re taking a big risk if you combine all three without first knowing how you react – with doctors present.