Tetanus is a disease caused by a Gram- positive, spore- forming anaerobic rod called Clostridium tetani.This organism often exists in the spore form in the human and animal intestine and passes to the soil inthe feces. Tetanus is usually acquired by puncture of the skin from a wound with a piece of glass or other pointed object. The etiological agent grows in the dead tissue and produces a number of toxins, which have their effect on this tissue. These toxins prevent the destruction of acetylcholine in the synapse and encourage nerve impulses to pass into the muscles, where they cause continual muscle contractions symptomatic of tetanus. Since the primary effect is in the nervous system, tetanus is considered a disease of this system.