DefinitionPregnanediol is an inactive product that forms when the body breaks down the hormone progesterone. A test can be done to measure the amount of pregnanediol in urine. The urine test offers an indirect way to measure progesterone levels in the body.How the test is performedA 24-hour urine sample is needed.How to prepare for the testYour doctor may tell you to stop taking certain drugs that can affect the test. For example, ACTH may increase test measurements. Birth Control pills or progesterone may decrease test measurements.How the test will feelThe test involves only normal urination, and there is no discomfort.Why the test is performedBefore progesterone blood tests were available, this test was used to monitor pregnancies and check for possible problems with the ovaries or adre