IndicationAn osmolality test measures the concentration of particles in a solution. In this case, the solution is urine.ProcedureHow the test is performed: You are instructed to collect a "clean-catch" (midstream) urine sample. To obtain a clean-catch sample, men or boys should wipe clean the head of the penis. Women or girls need to wash the area between the lips of the vagina with soapy water and rinse well. As you start to urinate, allow a small amount of urine to fall into the toilet bowl (this clears the urethra of contaminants). Then, in a clean container, catch about 1 to 2 ounces of urine and remove the container from the urine stream. Give the container to the health-care provider or assistant. To collect a urine sample from an infant: Thoroughly wash the area around the urethra. Open a urine-collection bag (a plastic bag with adhesive paper on one end), and place it on your infant. For males, the entire penis can be placed in the bag with the adhesive attached to the skin. For females, the bag is placed over the labia. Place a diaper over the infant (bag and all). Check your baby frequently and remove the bag after the infant has urinated into it. The urine is then drained into a container for transport back to the health-care provider. No special preparation is necessary for this test.ResultsGreater-than-normal measurements may indicate:Addison's disease (rare)Congestive heart failureShockSyndrome of inappropriate ADH secretionLower-than-normal measurements may indicate:Aldosteronism (very rare)Diabetes insipidus (rare)Excess fluid intakeRenal tubular necrosisSevere pyelonephritisReviewed ByReview Date: 08/21/2011David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.