DefinitionGas gangrene is a potentially deadly form of tissue death (gangrene).See also: Necrotizing subcutaneous infectionAlternative NamesTissue infection - Clostridial; Gangrene - gas; Myonecrosis; Clostridial infection of tissuesCauses, incidence, and risk factorsGas gangrene is rare in the United States. The condition is most often caused by a bacteria called Clostridium perfringens.However, it also can be caused by Group A streptococcus. Staphylococcus aureus and Vibrio vulnificus can cause similar infections.Clostridium is present in most environments. As the bacteria grow, they can produce gas in body tissues and produce many different toxins that can damage tissues. Under low-oxygen (anaerobic) conditions, Clostridium produces toxins that cause tissue death and related symptoms.Ga