Metformin levels vary from individual to individual, depending on efficacy and tolerance and maximum daily sales. In adults, the recommended daily dose of metformin is 2550 mg. And in the case of children aged 10-18 years, it is 2000 mg. On the other hand, in adults, the maximum recommended daily dose is 2000 mg. Bigmate should be taken in divided doses with food and usually once a night with meals. Metformin should never be sucked or broken down. The initial level should be as low as possible so that the minimum application level required to keep the blood glucose level in the desired state can be determined and at the same time the discomfort of the digestive system can be minimized. Acceptable Dosage: For adults: The usual starting dose of metformin is 500 mg twice a day or 750 mg. With food once a day. 500 mg per week or 650 mg every 2 weeks. The maximum daily intake is increased to 2000 mg. Can be increased up to. The initial dose is 500 mg twice daily for 2 weeks and 650 mg twice daily. Patients can be monitored by applying doses. The total daily dose is 2000 mg. On top of that it can be taken with food in 3 divided doses for patient tolerance. In children: The normal starting dose of metformin is 500 mg with each meal. By 2 times daily. The dose increase rate should be 500 mg per week. Daily maximum 2000 mg in divided doses. Until. The safe use and efficacy of metformin has not yet been established in children under 10 years of age.