(1) increase in size Explanation: Red Blood cells contain haemoglobin which is what the oxygen binds with to form oxyhaemoglobin which is then transported to the different cells around the body. Oxygen bonds with the haemoglobin when it is at high partial pressure and then is released when there is a lower partial pressure of oxygen. At high altitudes there is lower atmospheric pressure of oxygen. This means that the current number of red blood cells in the body cannot meet the cells demands for oxygen.