Description : One functional sub-unit of multi-enzyme complex for de novo synthesis of fatty acids contains (A) One —SH group (B) Two —SH groups (C) Three —SH groups (D) Four —SH groups FATS AND FATTY ACID METABOLISM 87
Last Answer : Answer : B
Description : Formation of acetyl CoA from pyruvate for de novo synthesis of fatty acids requires (A) Pyruvate dehydrogenase complex (B) Citrate synthetase (C) ATP citrate lyase (D) All of these
Last Answer : Answer : D
Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form
Description : Acetyl CoA required for de novo synthesis of fatty acids is obtained from (A) Breakdown of existing fatty acids (B) Ketone bodies (C) Acetate (D) Pyruvate
Description : The maximum possible chain length of fatty acids formed in the pathway of de novo synthesis is (A) 16 Carbon atoms (B) 18 Carbon atoms (C) 20 Carbon atoms (D) 24 Carbon atoms
Last Answer : Answer : A
Description : De novo synthesis and oxidation of fatty acids differ in the following respect: (A) Synthesis occurs in cytosol and oxidation in mitochondria (B) Synthesis is decreased and oxidation increased by ... synthesis and FAD in oxidation (D) Malonyl CoA is formed during oxidation but not during synthesis
Description : C22 and C24, fatty acids required for the synthesis of sphingolipids in brain are formed by (A) De novo synthesis (B) Microsomal chain elongation (C) Mitochondrial chain elongation (D) All of these
Description : De novo synthesis of fatty acids requires all of the following except (A) Biotin (B) NADH (C) Panthothenic acid (D) ATP
Description : Acetyl CoA from mitochondria is transferred to cytoplasm for the de novo synthesis of fatty acid, by which enzyme?
Last Answer : ATP citrate lyase.
Description : What is the rate limiting enzyme of de novo synthesis of fatty acid?
Last Answer : Acetyl CoA carboxylase.
Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex
Description : Nucleotides required for the synthesis of nucleic acids can be obtained from (A) Dietary nucleic acids and nucleotides (B) De novo synthesis (C) Salvage of pre-existing bases and nucleosides (D) De novo synthesis and salvage
Description : An enzyme common to de novo synthesis of pyrimidine nucleotides and urea is (A) Urease (B) Carbamoyl phosphate synthetase (C) Aspartate transcarbamoylase (D) Argininosuccinase
Description : For de novo synthesis of purine nucleotides, glycine provides (A) One nitrogen atom (B) One nitrogen and one carbon atom (C) Two carbon atoms (D) One nitrogen and two carbon atoms
Description : In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased
Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it
Last Answer : Answer : C
Description : De novo synthesis of pyrimidine nucleotides is regulated by (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Both (A) and (B) (D) None of these
Description : During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate
Description : All the enzymes required for de novo synthesis of pyrimidine nucleotides are cytosolic except (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Dihydro-orotase (D) Dihydro-orotate dehydrogenase
Description : The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP
Description : De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes
Description : The available PRPP is used preferentially for (A) De novo synthesis of purine nucleotides (B) De novo synthesis of pyrimidine nucleotides (C) Salvage of purine bases (D) Salvage of pyrimidine bases
Description : In the pathway of de novo synthesis of purine nucleotides, all the following are allosteric enzymes except (A) PRPP glutamyl amido transferase (B) Adenylosuccinate synthetase (C) IMP dehydrogenase (D) Adenylosuccinase
Description : Xanthosine monophosphate is an intermediate during de novo synthesis of (A) TMP (B) CMP (C) AMP (D) GMP
Description : Inosine monophophate is an intermediate during the de novo synthesis of (A) AMP and GMP (B) CMP and UMP (C) CMP and TMP (D) All of these
Description : For de novo synthesis of purine nucleotides, aspartate provides (A) Nitrogen 1 (B) Nitrogen 3 (C) Nitrogen 7 (D) Nitrogen 9
Description : The nitrogen atoms for de novo synthesis of purine nucleotides are provided by (A) Aspartate and glutamate (B) Aspartate and glycine (C) Aspartate, glutamine and glycine (D) Aspartate, glutamate and glycine
Description : De novo synthesis of purine nucleotide occurs in (A) Mitochondria (B) Cytosol (C) Microsmes (D) Ribosomes
Description : De hovo synthesis of fatty acids occurs in (A) Cytosol (B) Mitochondria (C) Microsomes (D) All of these
Description : Synthesis of polyunsaturated fatty acids involves the enzyme systems: (A) Acyl transferase and hydratase (B) Desaturase and elongase (C) Ketoacyl-CoA reductase and hydratase (D) Dihydroxyacetone phosphate
Description : The carbon chain of fatty acids is shortened by 2 carbon atoms at a time. This involves successive reactions catalysed by 4-enzymes. These act the following order: (A) Acetyl CoA dehydrogenase, ... CoA dehydrogenase (D) Enoyl hydrase, β-OH acyl CoA dehydrogenase, acyl CoA dehydrogenase, thiolose,
Description : The synthesis of heme from protophyrin III is catalysed by the enzyme: (A) ALA synthase (B) Ferroreductase (C) Ferrooxidase (D) Ferrochelatase
Description : Synthesis of phosphatidylinositol by transfer of inositol to CDP diacylglycerol is catalysed by the enzyme: (A) CTP phosphatidate cytidyl transferase (B) Phosphatidate phosphohydrolase (C) CDP-diacylglycerol inositol transferase (D) Choline kinase
Description : In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate
Description : Hormones (A) Act as coenzyme (B) Act as enzyme (C) Influence synthesis of enzymes (D) Belong to B-complex group
Description : The enzyme amino acyl tRNA synthetase is involved in (A) Dissociation of discharged tRNA from 80S ribosome (B) Charging of tRNA with specific amino acids (C) Termination of protein synthesis (D) Nucleophilic attack on esterified carboxyl group of peptidyl tRNA
Description : The active site of an enzyme is formed by a few of the enzymes: (A) R groups of the amino acids (B) Amino groups of the amino acids (C) Carboxyl group of the amino acids (D) Exposed sulfur bonds
Description : Acetyl CoA required for extra mitochondrial fatty acid synthesis is produced by (A) Pyruvate dehydrogenase complex (B) Citrate lyase (C) Thiolase (D) Carnitine-acyl transferase
Description : Epinephrine increases the concentration of free fatty acids in plasma by increasing (A) Extramitochondrial fatty acid synthesis (B) Mitochondrial fatty acid chain elongation (C) Microsomal fatty acid chain elongation (D) Lipolysis in adipose tissue
Description : The synthesis of fatty acids is often termed reductive synthesis. (A) NADP+ (B) NADH (C) FADH2 (D) NADPH
Description : The main pathway for denovo synthesis of fatty acids occur in (A) Cytosol (B) Mitochondria (C) Microsomes (D) Nucleus
Description : Which of the following regulates lipolysis in adipocytes? (A) Activation of fatty acid synthesis mediated by CAMP (B) Glycerol phosphorylation to prevent futile esterification of fatty acids (C) ... result of hormone stimulated increases in CAMP levels (D) Activation of CAMP production by Insulin
Description : CTP is required for the synthesis of (A) Fatty acids (B) Proteins (C) Phospholipids (D) Cholesterol
Description : In the extra mitochondrial synthesis of fatty acids, CO2 is utilized (A) To keep the system anaerobic and prevent regeneration of acetyl CoA (B) In the conversion of malonyl to CoA hydroxybutyryl CoA (C ... of acetyl CoA to malonyl CoA (D) In the formation of acetyl CoA from 1 carbon intermediates
Description : A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these
Description : Acetyl CoA formed from pyruvate can be used for the synthesis of all the following except (A) Glucose (B) Fatty acids (C) Cholesterol (D) Steroid hormones
Description : Extramitochondrial synthesis of fatty acids occurs in (A) Mammary glands (B) Lungs (C) Brain (D) All of these
Description : For synthesis of prostaglandins, the essential fatty acids give rise to a fatty acid containing (A) 12 carbon atoms (B) 16 carbon atoms (C) 20 carbon atoms (D) 24 carbon atoms
Description : There is no net synthesis of glucose from fatty acids, why?
Last Answer : Pyruvate to acetyl CoA is a totally irreversible reaction.
Description : The protein, which is in fact a multifunctional enzyme complex in higher organism is (A) Acetyl transacylase (B) Malonyl transacylase (C) 3-Hydroxy acyl-ACP dehyratase (D) Fatty acid synthase