Perhaps, if it was a baby hippo. It has probably never happened unless in a bizarre zoo accident seeing as the anaconda is found in South America and the hippopotamus is found in Africa. There is a video circulating on video-sharing sites that features an anaconda disgorge something that looks like a hippo, however, this is a tapir and not a hippo. The largest animal that anacondas are known to tackle are 500 pd. capybaras, so by extension, perhaps a 500 p Of couse a snake could fite a hippo a anaconda could fite the biggest hippo in its mouth d. hippo would be fair game.