Humans have 22 pairs of homologous non-sex chromosomes (called autosomes), and one pair of sex chromosomes, making a total of 46 chromosomes in a genetically normal human.Each member of a pair is inherited from one of the two parents. In addition to the 22 pairs of homologous autosomes, female humans have a homologous pair of sex chromosomes (two Xs), while males have an X and a Y chromosome.