How did the global transfer of disease in the pre-modern world help in the colonization of the Americans? -SST 10th

How did the global transfer of disease in the pre-modern world help in the colonization of the Americans? -SST 10th
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(i) America was not conquered and colonized by Europeans with the help of superior fire power alone.  (ii) Germs, such as those of small pox were a helpful to a great extent.  (iii) Americans had no immunity against them as a result of long isolation. Once introduced, the germs spread deep into the continent decimating whole communities and paving way for conquest.
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