Generally, I would say yes. However, if you have very high-end needs, or an expensive printer (there's probably a tiny risk to the printer), it might not be worth it. All compatible cartridges are probably not created equal, so I would look for reviews. For standard text-printing on a cheapo inkjet, like your epson, I would give it a try. Maybe someone else can recommend a good ink cartridge knockoff brand. I used one in college for my epson and it was fine.