Answer: a, c, d, e The temporal events that initiate and propagate neutrophil recruitment and inflammation include endothelial cell activation and expression of endothelial-derived neutrophil adhesion molecules, neutrophil-endothelial cell adherence, and neutrophil transendothelial migration via established neutrophil chemotactic gradients. There are three major families of adhesion molecules which are expressed on the surface of leukocytes and endothelial cells and are important for leukocyte-endothelial cell interactions. These include the immunoglobin supergene family (ICAM-1, VCAM-1, and PECAM-1), the selectins (E-selectin, P-selectin and L-selectin), and the integrins. The leukocyte b2 integrin adhesion molecule family consists of three members with heterodimeric glycoproteins displayed as a variable alpha and a constant beta chain. Nitric oxide regulates the adhesion process both by direct influence on leukocyte binding as well as by regulation of regional blood flow. IL-8 is one of the most potent mediators of chemotaxis in the C-X-C chemokine family. It serves an important role in neutrophil recruitment and activation, and the continued propagation of the inflammatory response