Cytosolic and mitochondrial carbamoyl phosphate synthetase have the following similarity: (A) Both use ammonia as a substance (B) Both provide carbamoyl phosphate for urea synthesis (C) Both require N-acetylglutamate as an activator (D) Both are allosteric enzymes

Cytosolic and mitochondrial carbamoyl phosphate synthetase have the following similarity: (A) Both use ammonia as a substance (B) Both provide carbamoyl phosphate for urea synthesis (C) Both require N-acetylglutamate as an activator (D) Both are allosteric enzymes
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Answer : C
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All the enzymes required for de novo synthesis of pyrimidine nucleotides are cytosolic except (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Dihydro-orotase (D) Dihydro-orotate dehydrogenase

Description : All the enzymes required for de novo synthesis of pyrimidine nucleotides are cytosolic except (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Dihydro-orotase (D) Dihydro-orotate dehydrogenase

Last Answer : Answer : D

Cytosolic carbamoyl phosphate synthetase is activated by (A) Glutamine (B) PRPP (C) ATP (D) Aspartate

Description : Cytosolic carbamoyl phosphate synthetase is activated by (A) Glutamine (B) PRPP (C) ATP (D) Aspartate

Last Answer : Answer : B

Cytosolic carbamoyl phosphate synthetase is inhibited by (A) UTP (B) CTP (C) PRPP (D) TMP

Description : Cytosolic carbamoyl phosphate synthetase is inhibited by (A) UTP (B) CTP (C) PRPP (D) TMP

Last Answer : Answer : A

Transfer of the carbamoyl moiety of carbamoyl phosphate to ornithine is catalysed by a liver mitochondrial enzyme: (A) Carbamoyl phosphate synthetase (B) Ornithine transcarbamoylase (C) N-acetyl glutamate synthetase (D) N-acetyl glutamate hydrolase

Description : Transfer of the carbamoyl moiety of carbamoyl phosphate to ornithine is catalysed by a liver mitochondrial enzyme: (A) Carbamoyl phosphate synthetase (B) Ornithine transcarbamoylase (C) N-acetyl glutamate synthetase (D) N-acetyl glutamate hydrolase

Last Answer : Answer : B

An enzyme common to de novo synthesis of pyrimidine nucleotides and urea is (A) Urease (B) Carbamoyl phosphate synthetase (C) Aspartate transcarbamoylase (D) Argininosuccinase

Description : An enzyme common to de novo synthesis of pyrimidine nucleotides and urea is (A) Urease (B) Carbamoyl phosphate synthetase (C) Aspartate transcarbamoylase (D) Argininosuccinase

Last Answer : Answer : B

Control of urea cycle involves the enzyme: (A) Carbamoyl phosphate synthetase (B) Ornithine transcarbamoylase (C) Argininosuccinase (D) Arginase

Description : Control of urea cycle involves the enzyme: (A) Carbamoyl phosphate synthetase (B) Ornithine transcarbamoylase (C) Argininosuccinase (D) Arginase

Last Answer : Answer : A

De novo synthesis of pyrimidine nucleotides is regulated by (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Both (A) and (B) (D) None of these

Description : De novo synthesis of pyrimidine nucleotides is regulated by (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

Orotic aciduria type I reflects the deficiency of enzymes: (A) Orotate phosphoribosyl transferase and orotidylate decarboxylase (B) Dihydroorotate dehydrogenase (C) Dihydroorotase (D) Carbamoyl phosphate synthetase

Description : Orotic aciduria type I reflects the deficiency of enzymes: (A) Orotate phosphoribosyl transferase and orotidylate decarboxylase (B) Dihydroorotate dehydrogenase (C) Dihydroorotase (D) Carbamoyl phosphate synthetase

Last Answer : Answer : A

Carbamoyl phosphate required for urea synthesis is formed in (A) Cytosol (B) Mitochondria (C) Both (A) and (B) (D) None of these

Description : Carbamoyl phosphate required for urea synthesis is formed in (A) Cytosol (B) Mitochondria (C) Both (A) and (B) (D) None of these

Last Answer : Answer : B

Carbamoyl phosphate synthetase structure is marked by change in the presence of (A) N-Acetyl glutamate (B) N-Acetyl Aspartate (C) Neuraminic acid (D) Oxalate

Description : Carbamoyl phosphate synthetase structure is marked by change in the presence of (A) N-Acetyl glutamate (B) N-Acetyl Aspartate (C) Neuraminic acid (D) Oxalate

Last Answer : Answer : A

In the pathway of de novo synthesis of purine nucleotides, all the following are allosteric enzymes except (A) PRPP glutamyl amido transferase (B) Adenylosuccinate synthetase (C) IMP dehydrogenase (D) Adenylosuccinase

Description : In the pathway of de novo synthesis of purine nucleotides, all the following are allosteric enzymes except (A) PRPP glutamyl amido transferase (B) Adenylosuccinate synthetase (C) IMP dehydrogenase (D) Adenylosuccinase

Last Answer : Answer : D

ATP is required in following reactions of urea cycle: (A) Synthesis of carbamoyl phosphate and citrulline (B) Synthesis of citrulline and argininosuccinate (C) Synthesis of argininosuccinate and arginine (D) Synthesis of carbamoyl phosphate and argininosuccinate

Description : ATP is required in following reactions of urea cycle: (A) Synthesis of carbamoyl phosphate and citrulline (B) Synthesis of citrulline and argininosuccinate (C) Synthesis of argininosuccinate and arginine (D) Synthesis of carbamoyl phosphate and argininosuccinate

Last Answer : Answer : C

The metabolite which sustains urea cycle is (A) Ornithine (B) Citrulline (C) Carbamoyl phosphate (D) n-acetyl glutamate

Description : The metabolite which sustains urea cycle is (A) Ornithine (B) Citrulline (C) Carbamoyl phosphate (D) n-acetyl glutamate

Last Answer : Answer : C

Hyperammonaemia type I results from congenital absence of (A) Glutamate dehydrogenase (B) Carbamoyl phosphate synthetase (C) Ornithine transcarbamoylase (D) None of these

Description : Hyperammonaemia type I results from congenital absence of (A) Glutamate dehydrogenase (B) Carbamoyl phosphate synthetase (C) Ornithine transcarbamoylase (D) None of these

Last Answer : Answer : B

An enzyme of pyrimidine nucleotides biosynthesis regulated at the genetic level by apparently coordinate repression and derepression is (A) Carbamoyl phosphate synthetase (B) Dihydroorotate dehydrogenase (C) Thymidine kinase (D) Deoxycytidine kinase

Description : An enzyme of pyrimidine nucleotides biosynthesis regulated at the genetic level by apparently coordinate repression and derepression is (A) Carbamoyl phosphate synthetase (B) Dihydroorotate dehydrogenase (C) Thymidine kinase (D) Deoxycytidine kinase

Last Answer : Answer : A

An important finding in Hyperammonemia type II is (A) Increased serum gluatmine level (B) Enlarged liver (C) Mental retardation (D) Increased carbamoyl phosphate synthetase level

Description : An important finding in Hyperammonemia type II is (A) Increased serum gluatmine level (B) Enlarged liver (C) Mental retardation (D) Increased carbamoyl phosphate synthetase level

Last Answer : Answer : C

The enzyme carbamoyl phosphate synthetase requires (A) Mg++ (B) Ca++ (C) Na+ (D) K+

Description : The enzyme carbamoyl phosphate synthetase requires (A) Mg++ (B) Ca++ (C) Na+ (D) K+

Last Answer : Answer : A

Hyperargininemia, a defect in urea synthesis develops due to deficiency of the enzyme: (A) Ornithine transcarbamoylase (B) Argininosuccinase (C) Arginase (D) Argininosuccinate synthetase ENZYMES 157

Description : Hyperargininemia, a defect in urea synthesis develops due to deficiency of the enzyme: (A) Ornithine transcarbamoylase (B) Argininosuccinase (C) Arginase (D) Argininosuccinate synthetase ENZYMES 157

Last Answer : Answer : B

Fructose 2, 3 bi phosphate is a powerful allosteric activator of (A) Fructose 1, 6 diphosphatase (B) Phosphofructokinase (C) Hexokinase (D) Fructokinase

Description : Fructose 2, 3 bi phosphate is a powerful allosteric activator of (A) Fructose 1, 6 diphosphatase (B) Phosphofructokinase (C) Hexokinase (D) Fructokinase

Last Answer : Answer : B

Allosteric activator of glycogen synthase is (A) Glucose (B) Glucose-6-Phosphate (C) UTP (D) Glucose-1-phosphate

Description : Allosteric activator of glycogen synthase is (A) Glucose (B) Glucose-6-Phosphate (C) UTP (D) Glucose-1-phosphate

Last Answer : Answer : B

An enzyme which acts as allosteric regulator and sensitive to both phosphate concentration and to the purine nucleotides is (A) PRPP synthetase (B) PRPP glutamyl midotransferase (C) HGPR Tase (D) Formyl transferase

Description : An enzyme which acts as allosteric regulator and sensitive to both phosphate concentration and to the purine nucleotides is (A) PRPP synthetase (B) PRPP glutamyl midotransferase (C) HGPR Tase (D) Formyl transferase

Last Answer : Answer : A

In urea synthesis, the amino acid functioning solely as an enzyme activator: (A) N-acetyl glutamate(B) Ornithine (C) Citrulline (D) Arginine

Description : In urea synthesis, the amino acid functioning solely as an enzyme activator: (A) N-acetyl glutamate(B) Ornithine (C) Citrulline (D) Arginine

Last Answer : Answer : A

In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate

Description : In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate

Last Answer : Answer : A

All of the following are allosteric enzymes except (A) Citrate synthetase (B) a-Ketoglutarate dehdrogenase (C) Succinate thiokinase (D) Succinate dehydrogenase

Description : All of the following are allosteric enzymes except (A) Citrate synthetase (B) a-Ketoglutarate dehdrogenase (C) Succinate thiokinase (D) Succinate dehydrogenase

Last Answer : Answer : C

The two nitrogen of the pyrimidine ring are contributed by (A) Ammonia and glycine (B) Asparate and carbamoyl phosphate (C) Glutamine and ammonia (D) Aspartate and ammonia

Description : The two nitrogen of the pyrimidine ring are contributed by (A) Ammonia and glycine (B) Asparate and carbamoyl phosphate (C) Glutamine and ammonia (D) Aspartate and ammonia

Last Answer : Answer : B

A key substance in the committed step of pyrimidines biosynthesis is (A) Ribose-5-phosphate (B) Carbamoyl phosphate (C) ATP (D) Glutamine

Description : A key substance in the committed step of pyrimidines biosynthesis is (A) Ribose-5-phosphate (B) Carbamoyl phosphate (C) ATP (D) Glutamine

Last Answer : Answer : B

AMP is an allosteric inhibitor of (A) PRPP synthetase (B) Adenylosucciante synthetase (C) Both (A) and (B) (D) None of these

Description : AMP is an allosteric inhibitor of (A) PRPP synthetase (B) Adenylosucciante synthetase (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

All of the following enzymes are unique to purine nucleotide synthesis except (A) PRPP synthetase (B) PRPP glutamyl amido transferase (C) Adenylosuccinate synthetase (D) IMP dehydrogenase

Description : All of the following enzymes are unique to purine nucleotide synthesis except (A) PRPP synthetase (B) PRPP glutamyl amido transferase (C) Adenylosuccinate synthetase (D) IMP dehydrogenase

Last Answer : Answer : A

The following abnormality in PRPP synthetase can cause primary gout: (A) High Vmax (B) Low Km (C) Resistance to allosteric inihbition. (D) All of these

Description : The following abnormality in PRPP synthetase can cause primary gout: (A) High Vmax (B) Low Km (C) Resistance to allosteric inihbition. (D) All of these

Last Answer : Answer : D

GMP is an allosteric inhibitor of all the following except (A) PRPP synthetase (B) PRPP glutamyl amido synthetase (C) IMP dehydrogenase (D) Adenylosuccinate synthetase

Description : GMP is an allosteric inhibitor of all the following except (A) PRPP synthetase (B) PRPP glutamyl amido synthetase (C) IMP dehydrogenase (D) Adenylosuccinate synthetase

Last Answer : Answer : D

An allosteric inhibitor of adenylosuccinate synthetase is (A) AMP (B) ADP (C) GMP (D) GDP

Description : An allosteric inhibitor of adenylosuccinate synthetase is (A) AMP (B) ADP (C) GMP (D) GDP

Last Answer : Answer : A

Which of the following contributes nitrogen atoms to both purine and pyrimidine rings? (A) Aspartate (B) Carbamoyl phosphate (C) CO2 (D) Glutamine

Description : Which of the following contributes nitrogen atoms to both purine and pyrimidine rings? (A) Aspartate (B) Carbamoyl phosphate (C) CO2 (D) Glutamine

Last Answer : Answer : A

The enzymes of urea synthesis are found in (A) Mitochondria only (B) Cytosol only (C) Both mitochondria and cytosol (D) Nucleus

Description : The enzymes of urea synthesis are found in (A) Mitochondria only (B) Cytosol only (C) Both mitochondria and cytosol (D) Nucleus

Last Answer : Answer : C

Deficiency of urea cycle enzymes results into accumulation of citrulline argininosuccinate arginine in the liver resulting in increasing concentration of …….. in the blood. (A) Calcium (B) Sodium (C) Ammonia (D) Lipid

Description : Deficiency of urea cycle enzymes results into accumulation of citrulline argininosuccinate arginine in the liver resulting in increasing concentration of …….. in the blood. (A) Calcium (B) Sodium (C) Ammonia (D) Lipid

Last Answer : Answer : C

All of the following are required for synthesis of glutamine except (A) Glutamate (B) Ammonia (C) Pyridoxal phosphate (D) ATP

Description : All of the following are required for synthesis of glutamine except (A) Glutamate (B) Ammonia (C) Pyridoxal phosphate (D) ATP

Last Answer : Answer : C

Pyrimidine biosynthesis begins with the formation from glutamine, ATP and CO2, of (A) Carbamoyl aspartate (B) Orotate (C) Carbamoyl phosphate (D) Dihydroorotate

Description : Pyrimidine biosynthesis begins with the formation from glutamine, ATP and CO2, of (A) Carbamoyl aspartate (B) Orotate (C) Carbamoyl phosphate (D) Dihydroorotate

Last Answer : Answer : C

The highest energy level is present amongst the following in (A) 1, 3-Biphosphoglycerate (B) Creatine phosphate (C) Carbamoyl phosphate (D) Phosphoenol pyruvate

Description : The highest energy level is present amongst the following in (A) 1, 3-Biphosphoglycerate (B) Creatine phosphate (C) Carbamoyl phosphate (D) Phosphoenol pyruvate

Last Answer : Answer : D

Synthesis of the following enzymes is increased during starvation. (A) Digestive enzymes (B) Gluconeogenic enzymes (C) Urea cycle enzymes (D) Glucokinase

Description : Synthesis of the following enzymes is increased during starvation. (A) Digestive enzymes (B) Gluconeogenic enzymes (C) Urea cycle enzymes (D) Glucokinase

Last Answer : Answer : B

Pyridoxal phosphate is a coenzyme for (A) Glycogen synthetase (B) Phosphorylase (C) Both (A) and (B) (D) None of these

Description : Pyridoxal phosphate is a coenzyme for (A) Glycogen synthetase (B) Phosphorylase (C) Both (A) and (B) (D) None of these

Last Answer : Answer : B

Pick out the wrong statement. (A) Dehydration of ammonium carbamate to produce urea is endothermic (B) Direct use of liquid ammonia as a fertiliser for a tropical country like India is suitable (C) Gypsum (CaSO4 . 2H2O) is obtained as a by-product in the wet process for manufacture of ortho-phosphoric acid (D) Phosphate rock when reacted with dilute H2SO4 produces superphosphate

Description : Pick out the wrong statement. (A) Dehydration of ammonium carbamate to produce urea is endothermic (B) Direct use of liquid ammonia as a fertiliser for a tropical country like India ... manufacture of ortho-phosphoric acid (D) Phosphate rock when reacted with dilute H2SO4 produces superphosphate

Last Answer : (B) Direct use of liquid ammonia as a fertiliser for a tropical country like India is suitable

Which of the following fertilisers contains the least percentage of nitrogen? (A) Liquid ammonia (B) Urea (C) Ammonium phosphate (D) Ammonium sulphate

Description : Which of the following fertilisers contains the least percentage of nitrogen? (A) Liquid ammonia (B) Urea (C) Ammonium phosphate (D) Ammonium sulphate

Last Answer : (C) Ammonium phosphate

During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate

Description : During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate

Last Answer : Answer : B

The enzymes encoded by z, y and a genes of lac operon are inducible, and their inducer is (A) Lactose (B) Allo-lactose (C) Catabolite gene activator protein (D) All of these

Description : The enzymes encoded by z, y and a genes of lac operon are inducible, and their inducer is (A) Lactose (B) Allo-lactose (C) Catabolite gene activator protein (D) All of these

Last Answer : Answer : B

The following enzyme of urea cycle is present in cytosol: (A) Argininosuccinic acid synthetase (B) Argininosuccinase (C) Arginase (D) All of these

Description : The following enzyme of urea cycle is present in cytosol: (A) Argininosuccinic acid synthetase (B) Argininosuccinase (C) Arginase (D) All of these

Last Answer : Answer : D

An example of feedback inhibition is (A) Allosteric inhibition of hexokinase by glucose6-phosphate (B) Cyanide action on cytochrome (C) Sulpha drug on folic acid synthesizer bacteria (D) Reaction between succinic dehydrogenase and succinic acid

Description : An example of feedback inhibition is (A) Allosteric inhibition of hexokinase by glucose6-phosphate (B) Cyanide action on cytochrome (C) Sulpha drug on folic acid synthesizer bacteria (D) Reaction between succinic dehydrogenase and succinic acid

Last Answer : Answer : A

Glucose-6-phosphate is an allosteric inhibitor of (A) Glucokinase (B) Hexokinase (C) Phosphohexose isomerase (D) None of these

Description : Glucose-6-phosphate is an allosteric inhibitor of (A) Glucokinase (B) Hexokinase (C) Phosphohexose isomerase (D) None of these

Last Answer : Answer : B

Hexokinase is inhibited in an allosteric manner by (A) Glucose-6-Phosphate (B) Glucose-1-Phosphate (C) Fructose-6-phosphate (D) Fructose-1, 6-biphosphate

Description : Hexokinase is inhibited in an allosteric manner by (A) Glucose-6-Phosphate (B) Glucose-1-Phosphate (C) Fructose-6-phosphate (D) Fructose-1, 6-biphosphate

Last Answer : Answer : A

Lactose or its analogues act as positive regulators of lac operon by (A) Attaching to i gene and preventing its expression (B) Increasing the synthesis of catabolite gene activator protein (C) Attaching to promoter region and facilitating the binding of RNA polymerase holoenzyme (D) Binding to repressor subunits so that the repressor cannot attach to the operator locus

Description : Lactose or its analogues act as positive regulators of lac operon by (A) Attaching to i gene and preventing its expression (B) Increasing the synthesis of catabolite gene activator protein (C) ... holoenzyme (D) Binding to repressor subunits so that the repressor cannot attach to the operator locus

Last Answer : Answer : D

The key substance in the synthesis of purine, phosphoribosyl pyrophosphate is formed by (A) α-D-ribose 5-phosphate (B) 5-phospho β-D-ribosylamine (C) D-ribose (D) Deoxyribose

Description : The key substance in the synthesis of purine, phosphoribosyl pyrophosphate is formed by (A) α-D-ribose 5-phosphate (B) 5-phospho β-D-ribosylamine (C) D-ribose (D) Deoxyribose

Last Answer : Answer : A

The regulatory enzyme for haem synthesis is (A) ALA synthetase (B) haem synthetase (C) Both (A) and (B) (D) None of these

Description : The regulatory enzyme for haem synthesis is (A) ALA synthetase (B) haem synthetase (C) Both (A) and (B) (D) None of these

Last Answer : Answer : A