Description : Hepatic glycogenoloysis is increased by (A) Insulin (B) Glucagon (C) Epinephrine (D) Glucocorticoids ENZYMES 163
Last Answer : Answer : B
Description : Gluconeogenesis is decreased by (A) Glucagon (B) Epinephrine (C) Glucocorticoids (D) Insulin
Last Answer : D
Description : The activity of HMG-CoA reductase is inhibited by (A) A fungal inhibitor mevastatin (B) Probucol (C) Nicotinic acid (D) Clofibrate
Last Answer : Answer : A
Description : Cholesterol by a feed back mechanism inhibits the activity of (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Thilase (D) Mevalonate kinase
Description : The hormone activating the glycogen synthase activity is (A) Insulin (B) Glucagon (C) Epinephrine (D) ACTH
Description : Release of free fatty acids from adipose tissue is increased by all of the following except (A) Glucagon (B) Epinephrine (C) Growth hormone (D) Insulin
Last Answer : Answer : D
Description : It is unique that the following single antidiabetogenic hormone effectively counter acts the several diabetogenic hormones: (A) Glucagon (B) Glucocorticoids (C) Insulin (D) Growth hormone
Last Answer : Answer : C
Description : Insulin decreases the activity of (A) cAMP dependent protein kinase (B) HMG CoA-reductas (C) Phosphodiesterase (D) Acetyl CoA-carboxylase
Description : In the biosynthesis of cholesterol, the rate limiting enzyme is (A) Mevalonate kinase (B) HMG-CoA synthetase (C) HMG-CoA reductase (D) Cis-prenyl transferase
Description : For reduction enzyme HMG-CoA reductase requires cofactor: (A) NADPH (B) NADP (C) NAD (D) FAD
Description : HMG-CoA is converted to mevalonate by reduction catalysed by (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Mevalonate kinase (D) Thiolase
Description : The rage limiting step cholesterol biosynthesis is (A) Squalene synthetase (B) Mevalonate kinase (C) HMG CoA synthetase (D) HMG CoA reductase
Description : Lovastatin is a (A) Competitive inhibitor of acetyl CoA carboxylase (B) Competitive inhibitor of HMG CoA synthetase (C) Non-competitive inhibitor of HMG CoA reductase (D) Competitive inhibitor of HMG CoA reductase
Description : An enzyme required for the synthesis of ketone bodies as well as cholesterol is (A) Acetyl CoA carboxylase (B) HMG CoA synthetase (C) HMG CoA reductase (D) HMG CoA lyase
Description : This hormone has disulphide group: (A) Glucagon (B) Insulin (C) T4 (D) Epinephrine
Description : Whcih of the following hormone does not activate adenylate cyclase? (A) Epinephrine (B) Glucagon (C) Parathyroid hormone (D) Insulin
Description : The output of free fatty acids from adipose tissue is reduced by (A) Insulin (B) Glucagon (C) Growth hormone (D) Epinephrine
Description : The primary stimulus for insulin secretion is increased. (A) Blood level of epinephrine (B) Blood level of glucagon (C) Blood level of glucose (D) Water intake
Description : Glycogenoloysis is increased by (A) Glucagon (B) Insulin (C) Epinephrine (D) cAMP
Description : A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin
Last Answer : (C) Lovastatin
Description : Select the first line hypolipidemic drug/drugs for treating hypertriglyceridemia in a subject with normal cholesterol level: A. Fibrates B. HMG-CoA reductase inhibitors C. Nicotinic acid D. Both 'A' and 'C' are correc
Last Answer : D. Both 'A' and 'C' are correct
Description : Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level: A. A HMG-CoA reductase inhibitor B. A fibric acid derivative C. Gugulipid D. Nicotinic acid
Last Answer : A. A HMG-CoA reductase inhibitor
Description : Choose the most potent and most efficacious LDLcholesterol lowering HMG-CoA reductase inhibitor: A. Lovastatin B. Simvastatin C. Pravastatin D. Atorvastatin
Last Answer : D. Atorvastatin
Description : Which pair of hormones has opposite, antagonistic effects? A) insulin--glucagon B) insulin--progesterone C) estrogen--thyroxin D) thyroxin--parathyroid hormone E) epinephrine--norepinephrine
Last Answer : A) insulin--glucagon
Description : The primary biochemical lesion in homozygote with familial hypercholesterolemia (type IIa) is (A) Loss of feed back inhibition of HMG reductase (B) Loss of apolipoprotein B (C) Increased production of LDL from VLDL (D) Functional deficiency of plasma membrane receptors for LDL
Description : ACTH stimulates the secretion of (A) Glucocorticoids (B) Epinephrine (C) Thyroxine (D) Luteinizing hormone
Description : All the following hormones promote hyperglycemia except (A) Epinephrine (B) Norepinephrine (C) Insulin (D) Glucagon
Description : The desaturation and chain elongation system of polyunsaturated fatty acid are enhanced by (A) Insulin (B) Glucagon (C) Epinephrine (D) Thyroxine
Description : Hepatic liponenesis is stimulated by: (A) cAMP (B) Glucagon (C) Epinephrine (D) Insulin
Description : Reactivation of inactive liver phosphorylase is normally favoured by (A) Insulin (B) Epinephrine (C) ACTH (D) Glucagon
Description : Select the correct statement. (a) Glucocorticoids stimulate gluconeogenesis. (b) Glucagon is associated with hypoglycemia. (c) Insulin acts on pancreatic cells and adipocytes. (d) Insulin is associated with hyperglycemia
Last Answer : (a) Glucocorticoids stimulate gluconeogenesis.
Description : The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase
Description : What is the cascade of events that follows a stress or trauma to produce adrenal reaction? A) hypothalamus (ACTH-releasing hormone)-anterior pituitary (ACTH)-adrenal cortex mineralocorticoids and ... ) E) adrenal cortex (hormones)-hypothalamus (ACTH-releasing hormone)-anterior pituitary (ACTH)
Last Answer : A) hypothalamus (ACTH-releasing hormone)-anterior pituitary (ACTH)-adrenal cortex mineralocorticoids and glucocorticoids (regulate metabolism and sugar level)
Description : A 55-year-old male undergoes a total abdominal colectomy. Which of the following statement(s) is/are true concerning the hormonal response to the surgical procedure? a. Adrenocorticotropic ... in serum insulin and a fall in glucagon accelerate hepatic glucose production and maintain gluconeogenesis
Last Answer : Answer: a, c One of the earliest consequence of a surgical procedure is the rise in levels of circulating cortisol that occur in response to a sudden outpouring of ACTH ... hepatic glucose production, and, with other hormones (epinephrine and glucocorticoids), gluconeogenesis is maintained
Description : Which hormone causes dilation of blood vessels, increased oxygen consumption and glucogenesis? (a) Glucagon (b) ACTH (c) Insulin (d) Adrenaline
Last Answer : (d) Adrenaline
Description : Which hormones do stimulate the production of pancreatic juice and bicarbonate? (a) Angiotensin and epinephrine (b) Gastrin and insulin (c) Cholecystokinin and secretin (d) Insulin and glucagon
Last Answer : (c) Cholecystokinin and secretin
Description : Cyclic AMP is formed from ATP by the enzyme adenylate cyclase which is activated by the hormone: (A) Insulin (B) Epinephrine (C) Testosterone (D) Progesterone
Last Answer : B
Description : This pancreatic hormone promotes hypogenesis: (A) Insulin (B) Glucagon (C) Stomato station (D) Pancreozymine
Description : Which of the following hormones are synthesized as prehormones (A) Vasopressin and oxytocin (B) Growth hormone and insulin (C) Insulin and parathyroid hormone (D) Insulin and Glucagon
Description : This pancreatic hormone increases the blood-sugar level: (A) Insulin (B) Glucagon (C) Pancreozymin (D) Pancreatic polypeptide
Description : Secretion of Insulin-like Growth Factor-I is promoted by (A) Insulin (B) Glucagon (C) Growth hormone (D) Somatomedin C
Description : Acromegaly results due to excessive release of (A) Thyroxine (B) Growth hormone (C) Insulin (D) Glucagon
Description : Which of the following hormone increases the absorption of glucose from G.I.T? (A) Insulin (B) Throid hormones (C) Glucagon (D) FSH
Description : Which of the following statement(s) is/are true concerning the neuroendocrine responses to shock? a. Sympathetic nerve endings release epinephrine which is responsible for greater than 80% ... injury and sepsis d. The renin-angiotensin axis further augments the sympathetic-mediated vasoconstriction
Last Answer : Answer: c, d The neuroendocrine response to shock attempts to achieve restoration of effective blood volume, mobilization of metabolic substrates, and maintenance of central ... . Angiotensin II is an extremely effective vasoconstrictor that further augments sympathetic-mediated vasoconstriction
Description : In the biosynthesis of cholesterol, the step which controls the rate and locus of metabolic regulation is (A) Geranyl pyrophosphate farnesyl pyrophosphate (B) Squalene → lanosterol (C) HMG CoA → mevalonate (D) Lanosterol → 1, 4-desmethyl lanosterol
Description : NAD is required as a coenzyme for (A) Malate dehydrogenase (B) Succinate dehydrogenase (C) Glucose-6-phosphate dehydrogenase (D) HMG CoA reductae
Description : The ‘Committed step’ in the biosynthesis of cholesterol from acetyl CoA is (A) Formation of acetoacetyl CoA from acetyl CoA (B) Formation of mevalonate from HMG CoA (C) Formation of HMG CoA from acetyl CoA and acetoacetyl CoA (D) Formation of squalene by squalene synthetase
Description : HMG CoA is formed in the metabolism of (A) Cholesterol, ketones and leucine (B) Cholesterol, fatty acid and Leucine (C) Lysine, Lecuine and Isoleucine (D) Ketones, Leucine and Lysine
Description : A hydrocarbon formed in cholesterol synthesis is (A) Mevalonate (B) HMG CoA (C) Squalene (D) Zymosterol
Description : What is HMG CoA synthase?
Last Answer : It is the rate-limiting-enzyme in ketogenesis pathway.