Description : In which of the following techniques the sample is kept below triple point? (A) Lyophilization (B) Spray drying (C) Spray congealing (D) Centrifugation
Last Answer : (A) Lyophilization
Description : Which one of the following is NOT an ex-officio member of Pharmacy Council of India? (A) The Director General of Health Services (B) The Director of Central Drugs Laboratory (C) The Drugs Controller General of India (D) The Director of Pharmacopoeia Laboratory
Last Answer : (D) The Director of Pharmacopoeia Laboratory
Description : It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be (A) 600 mg (B) 300 mg (C) 30 mg (D) 60 mg
Last Answer : (B) 300 mg
Description : The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be (A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L
Last Answer : (A)10 L
Description : How many mL of a 1:500 w/v stock solution should be used to make 5 liters of 1:2000 w/v solution? (A) 750 mL (B) 1000 mL (c) 1250 mL (D) 1500 mL
Last Answer : (c) 1250 mL
Description : Class 100 area is referred to (A) Manufacturing area (B) Aseptic area (C) Clean room (D) Ware house
Last Answer : (B) Aseptic area
Description : Geriatric population should be included in the following Phase of clinical trials (A) Phase I (B) Phase II (C) Phase III (D) Phase
Last Answer : (B) Phase II
Description : A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%
Last Answer : (C) 12.5%
Description : Rabies vaccine (living) is prepared using (A) Sheep blood (B) Mice lymph (C) Horse plasma (D) Fertile eggs
Last Answer : (D) Fertile eggs
Description : In nail polish, following polymer is used as a film-former : (A) Nitrocellulose (B) Polylactic acid (C) Hydroxypropyl methylcellulose (D) Cellulose acetate phthalate
Last Answer : (A) Nitrocellulose
Description : Drugs in suspensions and semi-solid formulations always degrade by (A) first order kinetics (B)second order kinetics (C) zero order kinetics (D) non-linear kinetics
Last Answer : (C) zero order kinetics
Description : The following protein/polypeptide has a quaternary structure : (A) cc-Chymotrypsin (B) Hemoglobin (C) Insulin (D) Myoglobin
Last Answer : (B) Hemoglobin
Description : Many xenobiotics are oxidized by cytochrome P450 in order to (A) increase their biological activity (B) increase their disposition in lipophilic compartments of the body (C) increase their aqueous solubility (D) all of the above
Last Answer : (D) all of the above
Description : The temperature condition for storage of drug products under cold temperature is given as : (A) temperature between 8°C and 25°C (B) temperature below 20 C (C) temperature at 0°C (D) temperature between 2c C and S: C
Last Answer : (D) temperature between 2c C and S: C
Description : Drugs following one compartment open model pharmacokinetics eliminate (A) bi-exponentially (B) tri-exponentially (C) non-exponentially (D) mono-exponentially
Last Answer : (D) mono-exponentially
Description : Coulter counter is used in determination of (A) particle surface area (B) particle size (C) particle volume (D)all of A, B, C
Last Answer : (D)all of A, B, C
Description : Oxidative phosphorylation involves (A) Electron transport system (B) Substrate level phosphorylation (C) Reaction catalyzed by succinic thiokinase in TCA cycle (D) None of the above
Last Answer : (A) Electron transport system
Description : In Gas-Liquid Chromatography, some of the samples need to be derivatized in order to increase their (A) volatility (B) solubility (C)thermal conductivity (D) polarizability
Last Answer : (D) polarizability
Description : Glass transition temperature is detected through (A) X-Ray diffractometery (B) Solution calorimetery (C) Differential scanning calorimetery (D) Thermogravimetric analysis
Last Answer : (C) Differential scanning calorimetery
Description : In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than (A) 350 nm (B) 200 nm (C) 300 nm (D) 250 nm
Last Answer : (A) 350 nm
Description : Streptomycin can NOT be given orally for treatment of tuberculosis because (A) it gets degraded in the GIT (B) it causes severe diarrhoea (C) it causes metallic taste in the mouth (D) it is not absorbed from the GIT
Last Answer : (D) it is not absorbed from the GIT
Description : In thiazides following substituent is essential for diuretic activity : (A) Chloro group at position 6 (B) Methyl group at position 2 (C) Sulphamoyl group at position 7 (D) Hydrophobic group at position 3
Last Answer : (C) Sulphamoyl group at position 7
Description : One of the following statements is NOT true : (A) Accuracy expresses the correctness of measurement (B) Precision represents reproducibility of measurement (C) High degree of precision implies high degree of accuracy also (D) High degree of accuracy implies high degree of precesion also
Last Answer : (C) High degree of precision implies high degree of accuracy also
Description : Indicate the HPLC detector that is most sensitive to change in temperature : (A) PDA detector (B) Refractive Index detector (C) Electrochemical detector (D) Fluorescence detector
Last Answer : (B) Refractive Index detector
Description : Artemisinin contains the following group in its structure : (A) an endoperoxide (B) an exoperoxide (C) an epoxide (D) an acid hydrazide
Last Answer : (A) an endoperoxide
Description : Cyclophosphamide as anticancer agent acts as (A) alkylating agent before metabolism (B)alkylating agent after metabolism (C) phosphorylating agent after metabolism (D) DNA intercalating agent
Last Answer : (B)alkylating agent after metabolism
Description : A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin
Last Answer : (C) Lovastatin
Description : Proton pump inhibitors like omeprazole and lansoprazole contain the following ring system : (A) Pyrimidine (B)Benzimidazole (C) Benzothiazole (D) Oxindole
Last Answer : (B)Benzimidazole
Description : Selective serotonin reuptake inhibitor is (A) Imipramine (B) Iproniazide (C) Fluoxetin (D)Naphazoline
Last Answer : (C) Fluoxetin
Description : Barbiturates with substitution at the following position possess acceptable hypnotic activity : (A) 1,3-Disubstitution (B) 5,5-Disubstitution (C) 1,5-Disubstitution (D) 3,3-Disubstitution
Last Answer : (B) 5,5-Disubstitution
Description : Chemical nomenclature of procaine is (A) 2-Diethylaminoethyl 4-aminobenzoate (B) N,N-Diethyl 4-aminobenzoate (C) 4-Aminobenzamidoethyl amine (D) 4-Amino-2-diethylaminoethyl benzoate
Last Answer : Ans. A & D
Description : Nicotinic action of acetylcholine is blocked by the drug (A) Atropine (B) Carvedilol (C) Neostigmine ( D ) d-Tubocurarine
Last Answer : ( D ) d-Tubocurarine
Description : The common structural feature amongst the three categories of anticonvulsant drugs barbiturates, succinimides and hydantoins is (A) ureide (B) imidazolidinone (C) dihydropyrimidine (D) tetrahydropyrimidine
Last Answer : (A) ureide
Description : Amitryptyline is synthesized from the following starting material : (A) Phthalic anhydride (B) Terephthalic acid (C) Phthalamic acid (D) Phthalimide
Last Answer : (B) Terephthalic acid
Description : Stevens Johnson sjmdrome is the most common adverse effect associated with one of the following category of drugs : (A) Sulphonamides (B) Macrolides (C) Penicillins (D) Tetracyclines
Last Answer : (A) Sulphonamides
Description : Identify the one rational combination which has clinical benefit : (A) Norfloxacin – Metronidazole (B) Alprazolam - Paracetamol (C) Cisapride – Omeprazole (D)Amoxycillin - Clavulanic acid
Last Answer : (D)Amoxycillin - Clavulanic acid
Description : Ganciclovir is mainly used for the treatment of infection caused by (A) Cytomegalovirus (B) Candida albicans (C) Herpes zoster virus (D) Hepatitis B virus
Last Answer : Ans. A & C
Description : Which one of the following drugs is withdrawn from the market due to torsade de pointes? (A) Chlorpromazine (B) Astemizole (C) Haloperidol (D) Domperidone
Last Answer : (B) Astemizole
Description : The rate limiting step in cholesterol biosynthesis is one of the followings : (A) LDL-receptor concentration (B) VLDL secretion (C) Mevalonic acid formation (D) Co-enzyme A formation
Last Answer : (C) Mevalonic acid formation
Description : Digitalis toxicity is enhanced by co-administration of (A) Potassium (B) Quinidine (C) Diuretics (D) Antacids
Last Answer : Ans. B & C
Description : Aliskiren acts by (A) inhibiting the conversion of Angiotensin I to II (B) inhibiting the release of rennin (C) inhibiting the binding of Angiotensin II to the receptor (D) inhibiting the action of aldosterone
Last Answer : (B) inhibiting the release of rennin
Description : Select the correc: combination of drugs for the treatment of patients suffering from Hepatitis C : (A) Interferon with Ribavirin (B) Interferon with Zidovudine (C) Interferon with Stavudine (D) Interferon with Lamivudine
Last Answer : (B) Interferon with Zidovudine
Description : One mg of Lycopodium spores used in quantitative microscopy contains an average of (A) 94,000 spores (B) 92,000 spores (C) 90,000 spores (D) 91,000 spores
Last Answer : (A) 94,000 spores
Description : An example of N-glycoside is (A) Adenosine (B) Sinigrin (C) Rhein-8-glucoside (D) Aloin
Last Answer : (A) Adenosine
Description : Guggul lipids are obtained from (A) Commiphora molmol (B) Boswellia serrata (C) Commiphora wightii (D) Commiphora abyssinica
Last Answer : (C) Commiphora wightii
Description : Tropane alkaloids are NOT present in (A) Datura stramonium (B) Erythroxylum coca (C) Duboisia myoporoides (D) Lobelia inflata
Last Answer : (D) Lobelia inflata
Description : Bacopa monnieri plant belongs to the family (A)Scrophulariacea (B) Leguminosae (C) Polygalaceae (D) Rubiaceae
Last Answer : (A)Scrophulariacea
Description : Anisocytic stomata are present in (A) Senna (B)Digitalis (C) Belladonna (D) Coca
Last Answer : (C) Belladonna
Description : Alkaloids are NOT precipitated by (A) Mayer's reagent (B) Dragendroff Reagent (C) Picric acid (D) Millon's reagent
Last Answer : (D) Millon's reagent
Description : Triterpenoids are active constituents of (A) Jaborandi (B) Rhubarb (C) Stramonium (D) Brahmi
Last Answer : (D) Brahmi