Description : Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level: A. A HMG-CoA reductase inhibitor B. A fibric acid derivative C. Gugulipid D. Nicotinic acid
Last Answer : A. A HMG-CoA reductase inhibitor
Description : Select the first line hypolipidemic drug/drugs for treating hypertriglyceridemia in a subject with normal cholesterol level: A. Fibrates B. HMG-CoA reductase inhibitors C. Nicotinic acid D. Both 'A' and 'C' are correc
Last Answer : D. Both 'A' and 'C' are correct
Description : Lovastatin is a (A) Competitive inhibitor of acetyl CoA carboxylase (B) Competitive inhibitor of HMG CoA synthetase (C) Non-competitive inhibitor of HMG CoA reductase (D) Competitive inhibitor of HMG CoA reductase
Last Answer : Answer : D
Description : Choose the most potent and most efficacious LDLcholesterol lowering HMG-CoA reductase inhibitor: A. Lovastatin B. Simvastatin C. Pravastatin D. Atorvastatin
Last Answer : D. Atorvastatin
Description : HMG-CoA reductase activity is increased by administration of the hormone: (A) Insulin (B) Glucagon (C) Epinephrine (D) Glucocorticoids
Last Answer : Answer : A
Description : Cholesterol by a feed back mechanism inhibits the activity of (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Thilase (D) Mevalonate kinase
Last Answer : Answer : B
Description : In the biosynthesis of cholesterol, the rate limiting enzyme is (A) Mevalonate kinase (B) HMG-CoA synthetase (C) HMG-CoA reductase (D) Cis-prenyl transferase
Last Answer : Answer : C
Description : For reduction enzyme HMG-CoA reductase requires cofactor: (A) NADPH (B) NADP (C) NAD (D) FAD
Description : HMG-CoA is converted to mevalonate by reduction catalysed by (A) HMG-CoA synthetase (B) HMG-CoA reductase (C) Mevalonate kinase (D) Thiolase
Description : The rage limiting step cholesterol biosynthesis is (A) Squalene synthetase (B) Mevalonate kinase (C) HMG CoA synthetase (D) HMG CoA reductase
Description : An enzyme required for the synthesis of ketone bodies as well as cholesterol is (A) Acetyl CoA carboxylase (B) HMG CoA synthetase (C) HMG CoA reductase (D) HMG CoA lyase
Description : A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin
Last Answer : (C) Lovastatin
Description : Features of atorvastatin include the following: A. Dose to dose most potent HMG-CoA reductase inhibitor B. Higher ceiling of LDL-cholesterol lowering action than lovastatin C. Antioxidant property D. All of the above
Last Answer : D. All of the above
Description : Which hypolipidemic drug has been used to control and prevent pancreatitis in familial hypertriglyceridemia: A. Lovastatin B. Nicotinic acid C. Cholestyramine D. Clofibrate
Last Answer : B. Nicotinic acid
Description : Insulin decreases the activity of (A) cAMP dependent protein kinase (B) HMG CoA-reductas (C) Phosphodiesterase (D) Acetyl CoA-carboxylase
Description : The primary biochemical lesion in homozygote with familial hypercholesterolemia (type IIa) is (A) Loss of feed back inhibition of HMG reductase (B) Loss of apolipoprotein B (C) Increased production of LDL from VLDL (D) Functional deficiency of plasma membrane receptors for LDL
Description : HMG CoA is formed in the metabolism of (A) Cholesterol, ketones and leucine (B) Cholesterol, fatty acid and Leucine (C) Lysine, Lecuine and Isoleucine (D) Ketones, Leucine and Lysine
Description : In the biosynthesis of cholesterol, the step which controls the rate and locus of metabolic regulation is (A) Geranyl pyrophosphate farnesyl pyrophosphate (B) Squalene → lanosterol (C) HMG CoA → mevalonate (D) Lanosterol → 1, 4-desmethyl lanosterol
Description : NAD is required as a coenzyme for (A) Malate dehydrogenase (B) Succinate dehydrogenase (C) Glucose-6-phosphate dehydrogenase (D) HMG CoA reductae
Description : The ‘Committed step’ in the biosynthesis of cholesterol from acetyl CoA is (A) Formation of acetoacetyl CoA from acetyl CoA (B) Formation of mevalonate from HMG CoA (C) Formation of HMG CoA from acetyl CoA and acetoacetyl CoA (D) Formation of squalene by squalene synthetase
Description : A hydrocarbon formed in cholesterol synthesis is (A) Mevalonate (B) HMG CoA (C) Squalene (D) Zymosterol
Description : What is HMG CoA synthase?
Last Answer : It is the rate-limiting-enzyme in ketogenesis pathway.
Description : Cancer cells may become resistant to amethopterin by (A) Developing mechanisms to destroy amethopterin (B) Amplification of dihydrofolate reducatse gene (C) Mutation in the dihydrofolate reductase ... is no longer inhibited by amethopterin (D) Developing alternate pathway of thymidylate synthesis
Description : All of the following statements about thioredoxin reductase are true except: (A) It requires NADH as a coenzyme (B) Its substrates are ADP, GDP, CDP and UDP (C) It is activated by ATP (D) It is inhibited by dADP
Description : Two molecules of acetyl-CoA condense to form acetoacetyl-CoA catalysed by (A) Thiolase (B) Kinase (C) Reductase (D) Isomerase
Description : Synthesis of polyunsaturated fatty acids involves the enzyme systems: (A) Acyl transferase and hydratase (B) Desaturase and elongase (C) Ketoacyl-CoA reductase and hydratase (D) Dihydroxyacetone phosphate
Description : The rate limiting reaction in the lipogenic pathway is (A) Acetyl-CoA carboxylase step (B) Ketoacyl synthase step (C) Ketoacyl reductase step (D) Hydratase step
Description : All the following statements about acetyl CoA carboxylase are true except: (A) It is activated by citrate (B) It is inhibited by palmitoyl CoA (C) It can undergo covalent modification (D) Its dephosphorylated form is inactive
Description : β-oxidation of fatty acids is inhibited by (A) NADPH (B) Acetyl CoA (C) Malonyl CoA (D) None of these
Description : Formation of succinyl-CoA from α-Ketoglutarate is inhibited by (A) Fluoroacetate (B) Arsenite (C) Fluoride (D) Iodoacetate
Description : Lovastatin and mevastatin lower (A) Serum triglycerides (B) Serum cholesterol (C) Serum phospholipids (D) All of these
Description : An allosteric inhibitor of pyruvate dehydrogenase is (A) Acetyl CoA (B) ATP (C) NADH (D) Pyruvate
Description : The following are true about acetylcholine: a. it has a strong affinity for nicotinic receptors b. is derived from acetyl CoA and choline c. is synthesized by a reaction involving choline acetyltransferase d. all above
Last Answer : all above
Description : Which of the following is a steroid 5α-reductase inhibitor that has been found useful in benign prostatic hypertrophy and male pattern baldness: A. Flutamide B. Finasteride C. Prazosin D. Minoxidil
Last Answer : B. Finasteride
Description : Choose the correct statement about latanoprost: A. It is a PGF2α derivative used in glaucoma B. It is a selective α1 blocker used in benign hypertrophy of prostate C. It is a 5-α- ... reduce the size of enlarged prostate gland D. It is a PGE2 analogue used intravaginally for cervical priming
Last Answer : A. It is a PGF2α derivative used in glaucoma
Description : What is true of nicotinic acid as well as nicotinamide: A. Both possess vitamin B3 activity B. Both cause cutaneous vasodilatation C. Both lower plasma triglyceride and VLDL levels D. Both cause hyperglycaemia after prolonged medication
Last Answer : A. Both possess vitamin B3 activity
Description : Methotrexate blocks the synthesis of thymidine monophosphate by inhibiting the activity of the enzyme: (A) Dihydrofolate reductase (B) Orotate phosphoribosyl transferase (C) Ribonucleotide reductase (D) Dihydroorotase
Description : Ceruloplasmin shows the activity (A) As ferroxidase (B) As reductase (C) As ligase (D) As transferase
Description : Which mineral element controls the activity of Nitrate reductase ? (A) Fe (B) Mo (C) Zn (D) Ca
Description : In biosynthesis of cholesterol triparanol inhibits the activity of the enzyme: (A) ∆24 Reductase (B) Oxidosqualene-lanosterol cyclase (C) Isomerase (D) Squalene epoxidase ENZYMES 155
Description : Activity of ceruloplasmin shown in vitro: (A) Reductase (B) Hydrolase (C) Ligase (D) Oxidase
Description : Which of the following is a microsomal enzyme inducer? (A) Indomethacin (B) Clofibrate (C) Tolbutamide (D) Glutethamide
Description : Hypolipidemic drugs reduce serum cholesterol and triacylglycerol. The effect of clofibrate is attributed to (A) Block in absorption from G.I.T. (B) Decrease in secretion of triacylglycerol and cholesterol ... by liver (C) Block in the reabsorption of bile acids (D) Decreased synthesis of cholesterol
Description : Which of the following features would be expected on lipid analysis in a 57 year old female with two year history of primary biliary cirrhosis? 1) A lipaemic appearance of the serum would be ... xanthomas 5) No evidence of a dyslipidaemia would be expected with this short a duration of disease
Last Answer : Answers-4 In prolonged cholestasis features include: increased serum cholesterol, a moderate increase in triglyceride, the serum is not lipaemic, and reduced HDL levels. Clinical features include: ... persisted for more than 3 months sometimes fat deposits may involve bone and peripheral nerves.
Description : Insulin regulates fatty acid synthesis by (A) Dephosphorylating of acetyl CoA carboxylase (B) Activating phosphorylase (C) Inhibiting malonyl CoA formation (D) Controlling carnitine-Acyl CoA transferase activity
Description : A patient with coronary artery disease has raised serum triglyceride level (500 mg/dl) but normal total cholesterol level (150 mg/dl). Which hypolipidemic drug should be prescribed: A. Probucol B. Gemfibrozil C. Cholestyramine D. Lovastatin
Last Answer : B. Gemfibrozil
Description : Peptidyl transferase activity of 50 S ribosomal subunits is inhibited by (A) Rifampicin (B) Cycloheximide (C) Chloramphenicol (D) Erythromycin
Description : Activity of cytochrome oxidase is inhibited by (A) Sulphite (B) Sulphate (C) Arsenite (D) Cyanide
Description : Pyruvate dehydrogenase activity is inhibited by (A) Mercury (B) Zinc (C) Calcium (D) Sodium