Description : All of the following intermediates of citric acid cycle can be formed from amino acids except (A) α-Ketoglutarate (B) Fumarate (C) Malate (D) Oxaloacetate
Last Answer : Answer : C
Description : All of the following compounds are intermediates of TCA cycle except (A) Maleate (B) Pyruvate (C) Oxaloacetate (D) Fumarate
Last Answer : Answer : B
Description : The example of generation of a high energy phosphate at the substrate level in the citric acid cycle is the reaction: (A) Isocitrate α-Ketoglutarate (B) Succinate α-fumarate (C) Malate α-oxaloacetate (D) Succinyl CoA α-Succinate
Last Answer : Answer : D
Description : The substance which may be considered to play a catalytic role in citric acid cycle is (A) Oxaloacetate (B) Isocitrate (C) Malate (D) Fumarate
Last Answer : Answer : A
Description : Out of 24 mols of ATP formed in TCA cycle, 2 molecules of ATP can be formed at “substrate level” by which of the following reaction ? (A) Citric acid→ Isocitric acid (B) Isocitrate→ Oxaloacetate (C) Succinic acid→ Fumarate (D) Succinylcat→ Succinic acid
Last Answer : D
Description : The carrier of the citric acid cycle is (A) Succinate (B) Fumarate (C) Malate (D) Oxaloacetate
Description : The initial step of the citric acid cycle is (A) Conversion of pyruvate to acetyl-CoA (B) Condensation of acetyl-CoA with oxaloacetate (C) Conversion of citrate to isocitrate (D) Formation of α -ketoglutarate catalysed by isocitrate dehydrogenase
Description : Mitochondrial membrane is freely preamble to (A) Pyruvate (B) Malate (C) Oxaloacetate (D) Fumarate
Description : The reaction of Kreb’s cycle which does not require cofactor of vitamin B group is (A) Citrate isocitrate (B) α -Ketoglutarate succinate (C) Malate oxaloacetate (D) Succinate fumarate
Description : Fluoroacetate inhibits the reaction of citric acid cycle: (A) Isocitrate α-Ketoglutarate (B) Fumarate α-Malate (C) Citrate α-cis-aconitate (D) Succinate α-fumarate
Description : A compound serving a link between citric acid cycle and urea cycle is (A) Malate (B) Citrate (C) Succinate (D) Fumarate
Description : If all the enzymes, intermediates and cofactors of the citric acid cycle as well as an excess of the starting substrate acetylCoA are present and functional in an organelle free solution at the appropriate ... oxygen (B) Half life of enzyme (C) Turnover of intermediates (D) Reduction of cofactors
Description : A carrier molecule in the citric acid cycle is (A) Acetyl-CoA (B) Citrate (C) Oxaloacetate (D) Malate
Description : The integrator between the TCA cycle and urea cycle is (A) Fumarate (B) Malate (C) Pyruvate (D) Citrate
Description : Active transport of sugar is depressed by the agent: (A) Oxaloacetate (B) Fumarate (C) Malonate (D) Succinate
Last Answer : C
Description : Connecting link between glycolysis and Krebs’ cycle before pyruvate entering Krebs’ cycle is changed to (a) oxaloacetate (b) PEP (c) pyruvate (d) acetyl CoA.
Last Answer : (d) acetyl CoA.
Description : Which of the following intermediates of metabolism can be both a precursor and a product of glucose? (A) Lactate (B) Pyruvate (C) Alanine (D) Acetyl-CoA
Description : Glucose is to photosynthesis as pyruvate is to _____. a. Oxidative Phosphorylation b. Glycolysis c. Fermentation d. Citric Acid Cycle
Last Answer : a. Oxidative Phosphorylation
Description : Which one of the following pairs is mismatched? a. Alcohol-fermentation b. Pyruvate-glycolysis c. Carbon dioxide-glycolysis d. NADH-citric acid cycle
Last Answer : c. Carbon dioxide-glycolysis
Description : In TCA cycle, oxalosuccinate is converted to α-ketoglutarate by the enzyme: (A) Fumarase (B) Isocitrate dehydrogenase (C) Aconitase (D) Succinase
Description : In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate
Description : Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin
Description : Pyridoxal phosphate is a coenzyme for (A) Glutamate oxaloacetate transaminase (B) Glutamate pyruvate transaminase (C) Tyrosine transaminase (D) All of these
Description : The coenzyme required for conversion of pyruvate to oxaloacetate is (A) FAD (B) NAD (C) TPP (D) Biotin
Description : While citrate is converted to isocitrate in the mitochondria, it is converted to _______ in the cytosol. (A) Acetyl CoA + oxaloacetate (B) Acetyl CoA + malonyl CoA (C) Acetyl CoA + Pyruvate (D) Acetyl CoA + acetoacetyl CoA
Description : Which of the following reactions is unique to gluconeogenesis? (A) Lactate Pyruvate (B) Phosphoenol pyruvate pyruvate (C) Oxaloacetate phosphoenol pyruvate (D) Glucose-6-phosphate Fructose-6-phosphate
Description : For conversion of oxaloacetate to phosphoenol pyruvate, high energy molecule is required in the form of (A) GTP only (B) ITP only (C) GTP (or) ITP (D) None of these
Description : In presence of the following cofactor, pyruvate carboxylase converts pyruvate to oxaloacetate: (A) ATP, Protein and CO2 (B) CO2 and ATP (C) CO2 (D) Protein
Last Answer : A
Description : Which of the following compound is a positive allosteric modifier of the enzyme pyruvate carboxylase? (A) Biotin (B) Acetyl CoA (C) Oxaloacetate (D) ATP
Description : An aneplerotic reaction which sustains the availability of oxaloacetate is the carboxylation of (A) Glutamate (B) Pyruvate (C) Citrate (D) Succinate
Last Answer : B
Description : Pyruvate carboxylase reaction (pyruvate to oxaloacetate) needs which co-enzyme?
Last Answer : Biotin and ATP.
Description : A regulator of the enzyme glucogen synthase is (A) Citric Acid (B) Pyruvate (C) Glucose-6-PO4 (D) GTP
Description : A regulator of the enzyme Glycogen synthase is (A) Citric acid (B) 2, 3 bisphosphoglycerate (C) Pyruvate (D) GTP
Description : Oxidative degradation of acetyl CoA in the citric acid cycle gives a net yield of all the following except (A) FADH2 (B) 3 NADH (C) 2 ATP (D) 2CO2
Description : All the following are produced during the citric acid cycle except: a. CO2. b. 02. c. ATP. d. NADH.
Last Answer : a. CO2.
Description : Which of the following statements regarding T.C.A cycle is true? (A) It is an anaerobic process (B) It occurs in cytosol (C) It contains no intermediates for Gluconeogenesis (D) It is amphibolic in nature
Description : Isocitrate dehydrogenase is allosterically inhibited by (A) Oxalosuccinate (B) α-Ketoglutarate (C) ATP (D) NADH
Description : Substrate-linked phosphorylation occurs in (A) Glycolytic pathway(B) Citric acid cycle (C) Both (A) and (B) (D) None of these
Description : In citric acid cycle, GDP is phosphorylated by (A) Succinate dehydrogenase (B) Aconitase (C) Succinate thiokinase (D) Fumarse
Description : Among citric acid cycle enzymes, a flavoprotein is (A) Malate (B) Fumarase (C) Succinate dehrogenase (D) Isocitrate dehrogenase
Description : In citric acid cycle, NAD is reduced in (A) One reactions (B) Two reactions (C) Three reactions (D) Four reactions
Description : The main source of reducing equivalents (NADPH) for lipogenesis is (A) Pentose phosphate pathway (B) Citric acid cycle (C) Glycolysis (D) Glycogenolysis
Description : The rate of citric acid cycle is controlled by the allosteric enzyme: (A) Aconitase (B) Fumarase (C) Fumarase (D) Malate dehydrogenase
Description : The number of ATP molecules generated for each turn of the citric acid cycle is (A) 8 (B) 12 (C) 24 (D) 38
Description : The enzyme -ketoglutarate dehydrogenase in the citric acid cycle requires (A) Lipoate (B) Folate (C) Pyridoxine (D) Inositol
Description : The reaction catalysed by α-ketoglutarate dehydrogenase in the citric acid cycle requires (A) NAD (B) NADP (C) ADP (D) ATP
Description : An enzyme of the citric acid cycle also found outside the mitochondria is (A) Isocitrate dehydrogenase (B) Citrate synthetase (C) α-Ketoglutarate dehydrogenase (D) Malate dehydrogenase
Description : The enzymes of the citric acid cycle are located in (A) Mitochondrial matrix (B) Extramitochondrial soluble fraction of the cell (C) Nucleus (D) Endoplasmic reticulum
Description : Most major metabolic pathways are considered mainly either anabolic or catabolic. Which of the following pathway is most correctly considered to be amphibolic? (A) Citric acid cycle (B) Gluconeogenesis (C) Lipolysis (D) Glycolysis
Description : NAD is required as a conenzyme in (A) Citric acid cycle (B) HMP shunt (C) β-Oxidation of fatty acids (D) Both (A) and (C)