Description : Acute intermittent porphyria (paraoxymal porphyria) is caused due to deficiency of (A) Uroporphyrinogen I synthase (B) ALA synthase (C) Coproporphyrinogen oxidase (D) Uroporphyrinogen decarboxylase
Last Answer : Answer : A
Description : Conversion of uroporphyrinogen III to coprophyrinogen III is catalysed by the enzyme.: (A) Uroporphyrinogen decarboxylase (B) Coproporphyrinogen oxidase (C) Protoporphyrinogen oxidase (D) Ferrochelatase
Description : The probable cause of porphyria cutanea tarda is deficiency of (A) Uroporphyrinogen oxidase (B) Coproporphyrinogen oxidase (C) Protoporphyrinogen oxidase (D) Uroporphyrinogen I synthase MINERAL METABOLISM 185
Description : The enzyme involved in congenial erythropoietic porphyria is (A) Uroporphyrinogen I synthase (B) Uroporphyrinogen III cosynthase (C) Protoporphyrinogen oxidase (D) Ferrochelatase
Last Answer : Answer : B
Description : Hereditary coproporphyria is caused due to deficiency of (A) Protoporphyrinogen oxidase (B) ALA synthase (C) ALA dehydratase (D) Coproporphyrinogen oxidase
Last Answer : Answer : D
Description : An enzyme involved in catabolism of catecholamines is (A) Dopa decarboxylase (B) Aromatic amino acid decarboxylase (C) Monoamine oxidase (D) Catechol oxidas
Last Answer : Answer : C
Description : Vitamin K is involved in posttranslational modification of the blood clotting factors by acting as cofactor for the enzyme: (A) Carboxylase (B) Decarboxylase (C) Hydroxylase (D) Oxidase
Description : Haem synthetase is congenitally deficient in (A) Congenital erythropoietic porphyria (B) Protoporphyria (C) Hereditary coproporphyria (D) Variegate porphyria
Description : In mammalian liver the rate controlling enzyme in porphyrin biosynthesis is (A) ALA synthase (B) ALA hydratase (C) Uroporphyrinogen I synthase (D) Uroporphyrinogen III cosynthase
Description : Vitamin K is involved in posttranslational modification of the blood clotting factors by acting as cofactor for the enzyme (A) Carboxylase (B) Decarboxylase (C) Hydroxylase (D) Oxidase
Last Answer : (A) Carboxylase
Description : The defective enzyme in histidinemia is (A) Histidine carboxylase (B) Histidine decarboxylase (C) Histidase (D) Histidine oxidase
Description : The condensation of 2 molecules of δ-aminolevulinate dehydratase contains (A) ALA synthase (B) ALA hydratase (C) Uroporphyrinogen synthase I (D) Uroporphyrinogen synthase III
Description : The characteristic urinary finding in porphyria cutanea tarda is (A) Increased quantity of porphobilinogen (B) Increased quantity of red cell protoporphyrin (C) Increased quantity of uroporphyrin (D) Increased quantity of δ-ALA
Description : Enzymic deficiency in β-aminoisobutyric aciduria is (A) Adenosine deaminase (B) Xanthine oxidase (C) Orotidylate decarboxylase (D) Transaminase
Description : Epinephrine is rapidly metabolized by (A) Monoamine oxidase (B) Deaminase (C) Transminase (D) Decarboxylase
Description : Which of the following is not an enzyme involved in glycolysis? (A) Euolase (B) Aldolose (C) Hexokinase (D) Glucose oxidase
Last Answer : D
Description : The following enzymes on the left are responsible for the synthesis of the neurotransmitters on the right: a. monoamine oxidase: noradrenaline b. cholinesterase: acetylcholine c. catechol-o-methyl transferase: dopamine d. dopa decarboxylase: adrenaline
Last Answer : dopa decarboxylase: adrenaline
Description : Which of the following statements are true of oxidants? A. In addition to their pathophysiologic roles in inflammation, injury, and infection, oxidants also have physiologic roles. B. Oxidants may ... involved the catalytic production of superoxide anion (O 2 ) by the enzyme xanthine oxidase.
Last Answer : Answer: ABCD DISCUSSION: Oxidants are reactive oxygen metabolites that have both physiologic and pathophysiologic roles. As potent oxidizing agents, oxidants are involved in cytochrome P ... leukocyte infiltration and activation, causing further tissue damage by the release of cytotoxic proteases
Description : Orotic aciduria type II reflects the deficiency of the enzyme: (A) Orotate phosphoribosyl transferase (B) Orotidylate decarboxylase (C) Dihydroorotase (D) Dihydroorotate dehydrogenase
Description : An enzyme of pyrimidine nucleotide biosynthesis sensitive to allosteric regulation is (A) Aspartate transcarbamoylase (B) Dihydroorotase (C) Dihydroorotate dehydrogenase (D) Orotidylic acid decarboxylase
Description : Conversion of deoxyuridine monophosphate to thymidine monophosphate is catalysed by the enzyme: (A) Ribonucleotide reductase (B) Thymidylate synthetase (C) CTP synthetase (D) Orotidylic acid decarboxylase
Description : Histamine is formed from histidine by the enzyme histidine decarboxylase in the presence of (A) NAD (B) FMN (C) HS-CoA (D) B6-PO4
Description : The enzyme catalyzing conversion of androstenedione to testosterone is a (A) Oxygenase (B) Dehydrogenase (C) Isomerase (D) Decarboxylase
Description : In the synthetic pathway of epinephrine, disulfiram (antabuse) inhibits the enzyme: (A) Tyrosine hydroxylase (B) Dopamine β-hydroxylase (C) DOPA decarboxylase (D) N-methyl transferase
Description : For Catecholamine biosynthesis the rate limiting enzyme is (A) DOPA decarboxylase (B) DOPAMINE β-hydroxylase (C) Tyrosine hydroxylase (D) Phenylalanine hydroxylase
Description : Biotin is a coenzyme of the enzyme (A) Carboxylase (B) Hydroxylase (C) Decarboxylase (D) Deaminase
Description : An inborn error, maple syrup urine disease is due to deficiency of the enzyme: (A) Isovaleryl-CoAhydrogenase (B) Phenylalnine hydroxylase (C) Adenosyl transferase (D) α-Ketoacid decarboxylase
Description : Platelets contain an enzyme which has important role in clotting in blood. This enzyme is known as (A) Cholinesterase (B) Transaminase (C) Decarboxylase (D) Thrombokinase
Description : The α-ketoacid is decarboxylated by H2O2 forming a carboxylic acid with one carbon atom less in the absence of the enzyme: (A) Catalase (B) Decarboxylase (C) Deaminase (D) Phosphatase
Description : Which of the following enzyme defects is associated with a characteristic body odour? 1) Phenylalanine aminotransferase 2) Galactose0-phosphate-uridyltransferase 3) Ornithine transcarbamylase deficiency 4) Fumaryl acetoacetase 5) Branched chain ketoacid decarboxylase
Last Answer : Answers-5 The following inborn errors of amino acid metabolism are associated with abnormal odours: Glutaric acidaemia type II (sweaty feet), hawkinsinuria (swimming pool), isovaleric acidaemia (sweaty feet), ... The general rule is that if a child smells peculiar he requires a metabolic work-up.
Description : The regulatory enzyme for haem synthesis is (A) ALA synthetase (B) haem synthetase (C) Both (A) and (B) (D) None of these
Description : The synthesis of heme from protophyrin III is catalysed by the enzyme: (A) ALA synthase (B) Ferroreductase (C) Ferrooxidase (D) Ferrochelatase
Description : A cofactor required for the activity of the enzyme ALA dehydratase is (A) Cu (B) Mn (C) Mg (D) Fe
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine oxidase is (A) Aspirin (B) Allopurinal (C) Colchicine (D) Phenyl benzoate
Description : Lesch-Nyhan syndrome, the sex linked recessive disorder is due to the lack of the enzyme: (A) Hypoxanthine-guanine phosphoribosyl transferse (B) Xanthine oxidase (C) Adenine phosphoribosyl transferase (D) Adenosine deaminase
Description : In humans purine are catabolised to uric acid due to lack of the enzyme: (A) Urease (B) Uricase (C) Xanthine oxidase (D) Guanase
Description : A deficiency of copper effects the formation of normal collagen by reducing the activity of which of the following enzyme? (A) Prolyl hydroxylase (B) Lysyl oxidase (C) Lysyl hydroxylase (D) Glucosyl transferase
Description : Selenium is a constituent of the enzyme: (A) Glutathione peroxidase (B) Homogentisate oxidase (C) Tyrosine hydroxylase (D) Phenylalanin hydroxylase
Description : The deficiency of copper decreases the activity of the enzyme: (A) Lysine oxidase (B) Lysine hydroxylase (C) Tyrosine oxidase (D) Proline hydroxylase
Description : Schardinger’s enzyme is (A) Lactate dehydrogenase (B) Xanthine dehydrogenase (C) Uric oxidase (D) L amino acid dehydrogenase
Description : Albinism is due to deficiency of the enzyme: (A) Phenylalanine hydroxylase (B) Tyrosinase (C) p-Hydroxyphenylpyruvic acid oxidase (D) Tyrosine dehydrogenase
Description : Refsum’s disease is due to deficiency of the enzyme: (A) Pytantate-α-oxidase (B) Glucocerebrosidase (C) Galactocerebrosidase (D) Ceramide trihexosidase
Description : The pentose phosphate pathway protects erythrocytes against hemolysis by assisting the enzyme: (A) Superoxide dismutase (B) Catalase (C) Glutathionic peroxidase (D) Cytochrome oxidase ENZYMES 149
Description : An enzyme which uses hydrogen acceptor as substrate is (A) Xanthine oxidase (B) Aldehyde oxidase (C) Catalase (D) Tryptophan oxygenase
Description : The enzyme using some other substance, not oxygen as hydrogen acceptor is (A) Tyrosinase (B) Succinate dehydrogenase (C) Uricase (D) Cytochrome oxidase
Description : An enzyme catalyzing oxidoreduction, using oxygen as hydrogen acceptor is (A) Cytochrome oxidase (B) Lactate dehydrogenase (C) Malate dehydrogenase (D) Succinate dehydrogenase
Description : Example of an extracellular enzyme is (A) Lactate dehydrogenase (B) Cytochrome oxidase (C) Pancreatic lipase (D) Hexokinase
Description : Fabry’s disease is due to the deficiency of the enzyme: (A) Ceramide trihexosidase (B) Galactocerebrosidase (C) Phytanic acid oxidase (D) Sphingomyelinase
Description : Alkaptonuria occurs due to deficiency of the enzyme: (A) Maleylacetoacetate isomerase (B) Homogentisate oxidase (C) p-Hydroxyphenylpyruvate hydroxylase (D) Fumarylacetoacetate hydrolase
Description : The enzyme dopamine β-oxidase which catalyses conversion of dopamine to norepinephrine requires (A) Vitamin A (B) Vitamin C (C) Vitamin E (D) Vitamin B12