Description : Acute intermittent porphyria (paraoxymal porphyria) is caused due to deficiency of (A) Uroporphyrinogen I synthase (B) ALA synthase (C) Coproporphyrinogen oxidase (D) Uroporphyrinogen decarboxylase
Last Answer : Answer : A
Description : The enzyme involved in variegate porphyria is (A) Protoporphyrinogen oxidase (B) Coproporphyrinogen oxidase (C) Uroporphyrinogen decarboxylase (D) ALA decarboxylase
Description : The enzyme involved in congenial erythropoietic porphyria is (A) Uroporphyrinogen I synthase (B) Uroporphyrinogen III cosynthase (C) Protoporphyrinogen oxidase (D) Ferrochelatase
Last Answer : Answer : B
Description : Hereditary coproporphyria is caused due to deficiency of (A) Protoporphyrinogen oxidase (B) ALA synthase (C) ALA dehydratase (D) Coproporphyrinogen oxidase
Last Answer : Answer : D
Description : Conversion of uroporphyrinogen III to coprophyrinogen III is catalysed by the enzyme.: (A) Uroporphyrinogen decarboxylase (B) Coproporphyrinogen oxidase (C) Protoporphyrinogen oxidase (D) Ferrochelatase
Description : The characteristic urinary finding in porphyria cutanea tarda is (A) Increased quantity of porphobilinogen (B) Increased quantity of red cell protoporphyrin (C) Increased quantity of uroporphyrin (D) Increased quantity of δ-ALA
Last Answer : Answer : C
Description : Conversion of the linear tetrapyrrole hydroxymethylbilane to uroporphyrinogen III (A) Occurs spontaneously (B) Catalysed by uroporphyrinogen I synthase (C) Catalysed by uroporphyrinogen III cosynthase (D) Catalysed by combined action of uroporphyrinogen I synthase and uroporphyrinogen III cosynthase
Description : The condensation of 2 molecules of δ-aminolevulinate dehydratase contains (A) ALA synthase (B) ALA hydratase (C) Uroporphyrinogen synthase I (D) Uroporphyrinogen synthase III
Description : In mammalian liver the rate controlling enzyme in porphyrin biosynthesis is (A) ALA synthase (B) ALA hydratase (C) Uroporphyrinogen I synthase (D) Uroporphyrinogen III cosynthase
Description : The best known cause of galactosemia is the deficiency of (A) Galactose 1-phosphate and uridyl transferase (B) Phosphoglucomutase (C) Galactokinase (D) Lactose synthase
Description : Protoporphyria (erythrohepatic) is characterized by the deficiency of (A) ALA synthase (B) ALA hydratase (C) Protophyrinogen oxidae (D) Ferrochelatase
Description : Her’s disease is characterized by deficiency of (A) Muscle phosphorylase (B) Liver phosphorylase (C) Debranching enzyme (D) Glycogen synthase
Description : Pompe ’s d isease is caused due to deficiency of (A) Lysosomal α-1→4 and 1→6-glucosidase (B) Glucose-6-phosphatase (C) Glycogen synthase (D) Phosphofructokinase
Description : Hypervitaminosis K in neonates may cause (A) Porphyria (B) Jaundice (C) Pellagra (D) Prolonged bleeding
Description : Maple syrup urine disease results from absence or serve deficiency of (A) Homogentisate oxidase (B) Phenylalanine hydroxylase (C) Branched chain amino acid transaminase (D) None of these
Description : Hypouricaemia can occur in (A) Xanthine oxidase deficiency (B) Psoriasis (C) Leukaemia (D) None of these
Description : Enzymic deficiency in β-aminoisobutyric aciduria is (A) Adenosine deaminase (B) Xanthine oxidase (C) Orotidylate decarboxylase (D) Transaminase
Description : An autosomal recessive disorder, xanthinuria is due to deficiency of the enzymes: (A) Adenosine deaminase (B) Xanthine oxidase (C) HGPRTase (D) Transaminase
Description : A deficiency of copper effects the formation of normal collagen by reducing the activity of which of the following enzyme? (A) Prolyl hydroxylase (B) Lysyl oxidase (C) Lysyl hydroxylase (D) Glucosyl transferase
Description : The deficiency of copper decreases the activity of the enzyme: (A) Lysine oxidase (B) Lysine hydroxylase (C) Tyrosine oxidase (D) Proline hydroxylase
Description : Albinism is due to deficiency of the enzyme: (A) Phenylalanine hydroxylase (B) Tyrosinase (C) p-Hydroxyphenylpyruvic acid oxidase (D) Tyrosine dehydrogenase
Description : Refsum’s disease is due to deficiency of the enzyme: (A) Pytantate-α-oxidase (B) Glucocerebrosidase (C) Galactocerebrosidase (D) Ceramide trihexosidase
Description : Fabry’s disease is due to the deficiency of the enzyme: (A) Ceramide trihexosidase (B) Galactocerebrosidase (C) Phytanic acid oxidase (D) Sphingomyelinase
Description : Alkaptonuria occurs due to deficiency of the enzyme: (A) Maleylacetoacetate isomerase (B) Homogentisate oxidase (C) p-Hydroxyphenylpyruvate hydroxylase (D) Fumarylacetoacetate hydrolase
Description : Ehlers-Danlos syndrome characterized by hypermobile joints and skin abnormalities is due to (A) Abnormality in gene for procollagen (B) Deficiency of lysyl oxidase (C) Deficiency of prolyl hydroxylase (D) Deficiency of lysyl hydroxylase
Description : In the biosynthesis of the iron protoporphyrin, the product of the condensation between succinyl-CoA and glycine is (A) α-Amino β-ketoadipic acid (B) δ-Aminolevulinate (C) Hydroxymethylbilane (D) Uroporphyrinogen I
Description : Haem synthetase is congenitally deficient in (A) Congenital erythropoietic porphyria (B) Protoporphyria (C) Hereditary coproporphyria (D) Variegate porphyria
Description : Main symptoms of congenital erythropoietic porphyria is (A) Yellowish teeth (B) Photosensitivity (C) Abdominal pain (D) Brownish urine
Description : The characteristic urinary finding in acute intermittent porphyria is (A) Increased quantity of uroporphyrin (B) Increased quantity of coproporphyrin I (C) Increased quantity of coproporphyrin III (D) Massive quantities of porphobilinogen
Description : The major symptom of acute intermittent porphyria includes (A) Abdominal pain (B) Photosensitivity (C) No neuropsychiatric signs (D) Dermatitis
Description : Which of the following is a characteristic feature of acute intermittent porphyria? 1) autosomal recessive inheritance 2) excessive faecal protoporphyrin excretion 3) excessive urinary porphobilinigoen between acute attacks 4) hypernatraemia during attacks 5) photosensitivity
Last Answer : Answers-3 Features of acute intermittent porphyria include urinary porphobilinogen excretion raised between attacks, hyponatraemia during an acute attack and autosomal dominant inheritance.
Description : Transferrin is a type of (A) Albumin (B) α-globulin (C) β1 globulin (D) γ-globulin MINERAL METABOLISM 203
Description : Respiratory quotient of an average mixed diet is about (A) 0.65 (B) 0.7 (C) 0.75 (D) 0.85 MINERAL METABOLISM 201
Description : The total amount of iodine in the body of an average adult is (A) 10–15 mg (B) 20–25 mg (C) 45–50 mg (D) 75–100 mg MINERAL METABOLISM 199
Description : Serum inorganic phosphorous rises in all the following conditions except (A) Hypoparathyroidism (B) Hypervitaminosis D (C) Chronic renal failure (D) After a carbohydrate-rich meal MINERAL METABOLISM 197
Description : In thalassemia, an amino acid is substituted in (A) Alpha chain (B) Beta chain (C) Alpha and beta chains (D) Any chain MINERAL METABOLISM 195
Description : Biological value of soyabean protein is (A) 86 (B) 71 (C) 64 (D) 54 MINERAL METABOLISM 193
Description : Sulphur is made available to the body by the amino acids: (A) Cystine and methionine (B) Taurine and alanine (C) Proline and hydroxyproline (D) Arginine and lysine MINERAL METABOLISM 191
Description : The amount of copper in the human body is (A) 50–80 mg (B) 100–150 mg (C) 400–500 mg (D) 500–1000 mg MINERAL METABOLISM 189
Description : The immunoglobulin having highest molecular weight is (A) Ig G (B) Ig M (C) Ig E (D) Ig A MINERAL METABOLISM 187
Description : If the reducing equivalents enter from NAD in the respiratory chain, the phsphate/oxygen (P:O) is (A) 1 (B) 2 (C) 3 (D) 4 MINERAL METABOLISM 183
Description : The defect in adrenal cortex responsible for lack of glucocorticoids and mineralcorticoids is (A) Androstenedione deficiency (B) 17 α -OH progesterone deficiency (C) C-21 hydroxylase deficiency (D) Testosterone deficiency HORMONE METABOLISM 209
Description : Lack of Glucocorticoids and mineral corticoids might be consequence of which of the following defects in the adrenal cortex? (A) Androstenadione deficiency (B) Estrone deficiency (C) 17 α-OH progesterone deficiency (D) C- α-Hydroxylase deficiency
Description : Many xenobiotics (A) Increase hepatic ALA synthase (B) Decrease hepatic ALA sythase (C) Increase hepatic ALA dehydrase (D) Decrease hepatic ALA dehydrase
Description : The synthesis of heme from protophyrin III is catalysed by the enzyme: (A) ALA synthase (B) Ferroreductase (C) Ferrooxidase (D) Ferrochelatase
Description : A regulator of the enzyme glucogen synthase is (A) Citric Acid (B) Pyruvate (C) Glucose-6-PO4 (D) GTP
Description : Brown adipose tissue is (A) A prominent tissue in human (B) Characterised by high content of mitochondria (C) Associated with high activity of ATP synthase (D) Characterised by low content of cytochromes
Description : The rate limiting reaction in the lipogenic pathway is (A) Acetyl-CoA carboxylase step (B) Ketoacyl synthase step (C) Ketoacyl reductase step (D) Hydratase step
Description : In fatty acids synthase of both bacteria and mammals, ACP (acyl carrier protein) contain the vitamin: (A) Thiamin (B) Pyridoxine (C) Riboflavin (D) Pantothenic acid
Description : The fatty acid synthase complex catalyses (A) 4 sequential enzymatic steps (B) 6 sequential enzymatic steps (C) 7 sequential enzymatic steps (D) 8 sequential enzymatic steps