Description : The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP
Last Answer : Answer : A
Description : Tetrahydrofolate is required as a coenzyme for the synthesis of (A) UMP (B) CMP (C) TMP (D) All of these
Last Answer : Answer : C
Description : Amethopterin and aminopterin decrease the synthesis of (A) TMP (B) UMP (C) CMP (D) All of these
Description : Inosine monophophate is an intermediate during the de novo synthesis of (A) AMP and GMP (B) CMP and UMP (C) CMP and TMP (D) All of these
Description : d-UMP is converted to TMP by (A) Methylation (B) Decarboxylation (C) Reduction (D) Deamination
Description : A purine nucleotide is (A) AMP (B) UMP (C) CMP (D) TMP
Description : Conversion of deoxyuridine monophosphate to thymidine monophosphate is catalysed by the enzyme: (A) Ribonucleotide reductase (B) Thymidylate synthetase (C) CTP synthetase (D) Orotidylic acid decarboxylase
Last Answer : Answer : B
Description : Aspartate transcarbamoylase is inhibited by (A) CTP (B) PRPP (C) ATP (D) TMP
Description : Cytosolic carbamoyl phosphate synthetase is inhibited by (A) UTP (B) CTP (C) PRPP (D) TMP
Description : The enzyme aspartate transcarbamoylase of pyrimidine biosynthesis is inhibited by (A) ATP (B) ADP (C) AMP (D) CTP
Last Answer : Answer : D
Description : G-proteins have a nucleotide binding site for (A) ADP/ATP (B) GDP/GTP (C) CDP/CTP (D) UDP/UTP
Description : Conversion of uridine diphosphate into deoxyuridine diphosphate requires all the following except (A) Ribonucleotide reductase (B) Thioredoxin (C) Tetrahydrobiopterin (D) NADPH
Description : Methotrexate blocks the synthesis of thymidine monophosphate by inhibiting the activity of the enzyme: (A) Dihydrofolate reductase (B) Orotate phosphoribosyl transferase (C) Ribonucleotide reductase (D) Dihydroorotase
Description : Reduction of ribonucleotide diphosphates (NDPs) to their corresponding deoxy ribonucleotide diphosphates (dNDPs) involves (A) FMN (B) FAD (C) NAD (D) NADPH
Description : Myeloma cells are lacking in (A) TMP synthetase (B) Formyl transferase (C) HGPRT (D) All of these
Description : For the synthesis of TMP from dump, a coenzyme is required which is (A) N10- Formyl tetrahydrofolate (B) N5- Methyl tetrahydrofolate (C) N5, N10- Methylene tetrahydrofolate (D) N5- Formimino tetrahydrofolate
Description : Xanthosine monophosphate is an intermediate during de novo synthesis of (A) TMP (B) CMP (C) AMP (D) GMP
Description : Phosphofructokinase key enzyme in glycolysis is inhibited by (A) Citrate and ATP (B) AMP (C) ADP (D) TMP
Description : In the biosynthesis of c-DNA, the joining enzyme ligase requires (A) GTP (B) ATP (C) CTP (D) UTP
Description : The mRNA ready for protein synthesis has the ________ cap. (A) ATP (B) CTP (C) GTP (D) UTP
Description : CTP synthetase forms CTP from (A) CDP and inorganic phosphate (B) CDP and ATP (C) UTP and glutamine (D) UTP and glutamate
Description : For synthesis of CTP and UTP, the amino group comes from (A) Amide group of Asparagine (B) Amide group of glutamine (C) α-Amino group of glutamine (D) α-Amino group of glutamate
Description : UTP is converted to CTP by (A) Methylation (B) Isomerisation (C) Amination (D) Reduction
Description : In some reactions, energy is captured in the form of (A) GTP (B) UTP (C) CTP (D) None of these
Description : Coenzymes derived from the vitamin shown below are required by enzymes involved in the synthesis of which of the following? (A) ATP (B) UTP (C) CTP (D) NADH
Description : Glycogenesis requires (A) GTP (B) CTP (C) UTP (D) None of these
Description : Synthesis of phosphatidylinositol by transfer of inositol to CDP diacylglycerol is catalysed by the enzyme: (A) CTP phosphatidate cytidyl transferase (B) Phosphatidate phosphohydrolase (C) CDP-diacylglycerol inositol transferase (D) Choline kinase
Description : In the reaction below, Nu TP stands for NuTP + glucose → Glucose 6–Phosphate + NuDP. (A) ATP (B) CTP (C) GTP (D) UTP
Description : The following is required for the formation of coenyzme A: (A) ATP (B) GTP (C) CTP (D) None of these
Description : CTP is required for the synthesis of (A) Fatty acids (B) Proteins (C) Phospholipids (D) Cholesterol
Description : The 2 energy rich compounds needed for protein biosynthesis are (A) ATP and GTP (B) ATP and UTP (C) ATP and CTP (D) ATP and TTP
Description : An essential for converting Glucose to Glycogen in Liver is (A) Lactic acid (B) GTP (C) CTP (D) UTP CARBOHYDRATES AND CARBOHYDRATE METABOLISM 19
Last Answer : D
Description : All of the following statements about thioredoxin reductase are true except: (A) It requires NADH as a coenzyme (B) Its substrates are ADP, GDP, CDP and UDP (C) It is activated by ATP (D) It is inhibited by dADP
Description : All of the following statements about tRNA are true except (A) It is synthesized as a large precursor (B) It is processed in the nucelolus (C) It has no codons or anticodons (D) Genes for rRNA are present in single copies
Description : All the following statements about carnitine are true except (A) It can be synthesised in the human body (B) It can be synthesized from methionine and lysine (C) It is required for transport of short chain fatty acids into mitochondria (D) Its deficiency can occur due to haemodialysis
Description : All the following statements about ketone bodies are true except (A) Their synthesis increases in diabetes mellitus (B) They are synthesized in mitchondria (C) They can deplete the alkali reserve (D) They can be oxidized in the liver
Description : All of the following statements about proline are true except (A) It is an imino acid (B) It can be synthesized from glutamate (C) It can be catabolised to glutamate (D) Free proline can be hydroxylated to hydroxyproline
Description : All of the following statements about aspartate are true except (A) It is non-essential amino acid (B) It is a dicarboxylic amino acid (C) It can be synthesized from pyruvate and glutamate (D) It can be converted into asparagine
Description : During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate
Description : Which one of the following contributes nitrogen atoms to both purine and pyrimidine rings? (A) Aspartate (B) Carbanoyl phosphate (C) Carbondioxide (D) Tetrahydrofolate
Description : Which one of the following causes frame shift mutation? (A) Transition (B) Transversion (C) Deletion (D) Substitution of purine to pyrimidine
Description : In DNA, genetic information is located in (A) Purine bases (B) Pyrimidine bases (C) Purine and pyrimidine bases (D) sugar
Description : The structural stability of the double helix of DNA is as cribbed largely to (A) Hydrogen bonding between adjacent purine bases (B) Hydrophobic bonding between staked purine and ... Hydrogen bonding between adjacent pyrimidine bases (E) Hydrogen bonding between purine and pyrimidine bases
Description : All of the following occur in orotic aciduria except (A) Increased synthesis of pyrimidine nucleotides (B) Increased excretion of orotic acid in urine (C) Decreased synthesis of cytidine triphosphate (D) Retardation of growth
Description : The following coenzyme is required for catabolism of pyrimidine bases: (A) NADH (B) NADPH (C) FADH2 (D) None of these
Description : De novo synthesis of pyrimidine nucleotides is regulated by (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Both (A) and (B) (D) None of these
Description : All the enzymes required for de novo synthesis of pyrimidine nucleotides are cytosolic except (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Dihydro-orotase (D) Dihydro-orotate dehydrogenase
Description : Aspartate contributes the following carbon atoms of the pyrimidine nucelus: (A) C2 and C4 (B) C5 and C6 (C) C2, C4 and C6 (D) C4, C5 and C6
Description : The carbon atom at position 2 of pyrimidine nucleus is contributed by (A) CO2 (B) Glycine (C) Aspartate (D) Glutamine
Description : Nitrogen at position 3 of pyrimidine nucleus comes from (A) Glutamine (B) Glutamate (C) Glycine (D) Aspartate