Description : The first reaction unique to purine nucleotide synthesis is catalysed by (A) PRPP synthetase (B) PRPP glutamyl amido transferase (C) Phosphoribosyl glycinamide synthetase (D) Formyl transferase
Last Answer : Answer : B
Description : An enzyme which acts as allosteric regulator and sensitive to both phosphate concentration and to the purine nucleotides is (A) PRPP synthetase (B) PRPP glutamyl midotransferase (C) HGPR Tase (D) Formyl transferase
Last Answer : Answer : A
Description : For the synthesis of TMP from dump, a coenzyme is required which is (A) N10- Formyl tetrahydrofolate (B) N5- Methyl tetrahydrofolate (C) N5, N10- Methylene tetrahydrofolate (D) N5- Formimino tetrahydrofolate
Last Answer : Answer : C
Description : Cytosolic carbamoyl phosphate synthetase is inhibited by (A) UTP (B) CTP (C) PRPP (D) TMP
Description : Conversion of inosine monophosphate to xanthine monophosphate is catalysed by (A) IMP dehydrogenase (B) Formyl transferase (C) Xanthine-guanine phosphoribosyl transferase (D) Adenine phosphoribosyl transferase
Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it
Description : All of the following enzymes are unique to purine nucleotide synthesis except (A) PRPP synthetase (B) PRPP glutamyl amido transferase (C) Adenylosuccinate synthetase (D) IMP dehydrogenase
Description : In the pathway of de novo synthesis of purine nucleotides, all the following are allosteric enzymes except (A) PRPP glutamyl amido transferase (B) Adenylosuccinate synthetase (C) IMP dehydrogenase (D) Adenylosuccinase
Last Answer : Answer : D
Description : Orotic aciduria type I reflects the deficiency of enzymes: (A) Orotate phosphoribosyl transferase and orotidylate decarboxylase (B) Dihydroorotate dehydrogenase (C) Dihydroorotase (D) Carbamoyl phosphate synthetase
Description : In the biosynthesis of cholesterol, the rate limiting enzyme is (A) Mevalonate kinase (B) HMG-CoA synthetase (C) HMG-CoA reductase (D) Cis-prenyl transferase
Description : Myeloma cells and lymphocytes can be fused by using (A) Calcium chloride (B) Ethidium bromide (C) Polyethylene glycol (D) DNA polymerase
Description : Monoclonal antibodies are prepared by cloning (A) Myeloma cells (B) Hybridoma cells (C) T-Lymphocytes (D) B-Lymphocytes
Description : Can a myeloma patient still harvest stem cells for transplant if they've already started chemo?
Last Answer : Protocols for multiple myeloma vary, so it depends on whether an autologous stem cell transplant is planned for your treatment. It’s not clear to me why there was an apparent rush, but you need to check with your oncologist.
Description : Hybridoma cells are (a) only cells having oncogenes (b) product of spore formation in bacteria (c) nervous cells of frog (d) hybrid cells resulting from myeloma cells.
Last Answer : (d) hybrid cells resulting from myeloma cells.
Description : Antibodies produced by a single clone of myeloma cells are referred to as _____ antibodies. a. Chimeric b. Monoclonal c. Polyclonal d. Hybrid
Last Answer : b. Monoclonal
Description : Aspartate transcarbamoylase is inhibited by (A) CTP (B) PRPP (C) ATP (D) TMP
Description : Tetrahydrofolate is required as a coenzyme for the synthesis of (A) UMP (B) CMP (C) TMP (D) All of these
Description : Amethopterin and aminopterin decrease the synthesis of (A) TMP (B) UMP (C) CMP (D) All of these
Description : The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP
Description : Xanthosine monophosphate is an intermediate during de novo synthesis of (A) TMP (B) CMP (C) AMP (D) GMP
Description : Inosine monophophate is an intermediate during the de novo synthesis of (A) AMP and GMP (B) CMP and UMP (C) CMP and TMP (D) All of these
Description : d-UMP is converted to TMP by (A) Methylation (B) Decarboxylation (C) Reduction (D) Deamination
Description : The first true pyrimidine ribonucleotide synthesized is (A) UMP (B) UDP (C) TMP (D) CTP
Description : A purine nucleotide is (A) AMP (B) UMP (C) CMP (D) TMP
Description : Phosphofructokinase key enzyme in glycolysis is inhibited by (A) Citrate and ATP (B) AMP (C) ADP (D) TMP
Description : A synthetic nucleotide analogue, 4-hydroxypyrazolopyrimidine is used in the treatment of (A) Acute nephritis (B) Gout (C) Cystic fibrosis of lung (D) Multiple myeloma
Description : In increase in α2-Globulin with loss of albumin in urine suggests (A) Primary immune deficiency (B) Nephrotic syndrome (C) Cirrhosis of liver (D) Multiple myeloma
Description : In one of the following the quality of the protein synthesized is affected: (A) Diabetes mellitus (B) Gont (C) Multiple myeloma (D) Primaquine sensitivity
Description : Bence Jones proteins may be excreted in urine of patients suffering from (A) Tuberculosis (B) Diabetes mellitus (C) Multiple myeloma (D) Hyperthyroidism
Description : Which of the following concerning the conjugation of bilirubin is correct? 1) is catalysed by a glucuronyl transferase 2) occurs in the Kupfer cells of the liver 3) is increased by valproate 4) is inhibited by rifampicin 5) is impaired in Dubin-Johnson syndrome
Last Answer : Answers-1 b - Hepatocytes. c - Enzyme inhibitor. d - Enzyme inducer. e - Conjugation is OK but excretion from the hepatocyte into the bile is impaired. (Gilbert's syndrome ... bilirubinaemia. Dubin-Johnson syndrome - bilirubin can't Depart from the hepatocyte - conjugated bilirubinaemia.)
Description : Elongation of a peptide chain involves all the following except (A) mRNA (B) GTP (C) Formyl-Met-tRNA (D) Tu, TS and G factors
Description : In E. coli the chain initiating amino acid in protein synthesis is (A) N-formyl methionine(B) Methionine (C) Serine (D) Cysteine
Description : The amino terminal of all polypeptide chain at the time of synthesis in E. coli is tagged to the amino acid residue: (A) Methionine (B) Serine (C) N-formyl methinine(D) N-formal serine
Description : Conversion of formylglycinamide ribosyl5-phosphate to formyl-glycinamide ribosyl-5-phosphate is inhibited by (A) Azaserine (B) Diazonorleucine (C) 6-Mercaptopurine (D) Mycophenolic acid
Description : In purine biosynthesis ring closure in the molecule formyl glycinamide ribosyl-5- phosphate requires the cofactors: (A) ADP (B) NAD (C) FAD (D) ATP and Mg++
Description : N10-formyl and N5N10-methenyl tetrahydrofolate contributes purine carbon atoms at position (A) 4 and 6 (B) 4 and 5 (C) 5 and 6 (D) 2 and 8
Description : The first amino acid incorporated in a polypeptide in a ribosome of a bacterium is (A) N formyl methionine (B) Methionine (C) Alamine (D) Glycine
Description : The first amino acid incorporated in a polypeptide in a ribosome of a human is (A) N formyl methionine (B) Methionine (C) Phenyl alanine (D) Hydroxy lysine
Description : Isoenzymes can be characterized by (A) Proteins lacking enzymatic activity that are necessary for the activation of enzymes (B) Proteolytic enzymes activated by hydrolysis (C) Enzymes with identical primary structure (D) Similar enzymes that catalyse different reaction
Description : Trimethoprim inhibits bacteria without affecting mammalian cells because: A. It does not penetrate mammalian cells B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate ... bacterial folate synthetase as well as dihydrofolate reductase enzymes D. All of the above
Last Answer : B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme
Description : What's the survival rate of Multiple Myeloma in a 17 year old girl?
Last Answer : Haven’t you talked to your doctor?You need to.Also get some books on the subject and read,read ,read!Maybe contact some groups in your area that deal with kind of disease.Start by talking to your doctor.
Description : What is a myeloma protein ?
Last Answer : It is a monoclonal immunoglobulin produced from a myeloma cell.
Description : Amyloidosis: a. the protein stained with Lugol's iodine b. the deposition is extracellular c. AL type is seen in 15% of patients with multiple myeloma. d. all above
Last Answer : all above
Description : Oral mucosa and skin pigmentation occurs in patient with:** A. Diabetes mellitus B. Addison’s disease C. Multiple myeloma D. Squamous cell carcinoma E. Bright’s disease F. Cushing’s disease
Last Answer : B. Addison’s disease
Description : Radiopaque lesions are seen in: A. Multiple myeloma B. Paget’s disease C. Hyperparathyroidism D. Chronic renal failure
Last Answer : B. Paget’s disease
Description : Biopsy is least useful in the diagnosis of, A. Geographic tongue B. Aphthous ulcer C. Cysts D. Granuloma E. Myeloma
Last Answer : A. Geographic tongue
Description : Unconjugated bilirubin is derived principally from: C A. glucuronyl transferase activity B. toxic liver injury C. breakdown of senescent red blood cells D. None of these
Last Answer : breakdown of senescent red blood cells
Description : During translation initiation in prokaryotes, a GTP molecule is needed in (a) formation of formyl-met-tRNA (b) binding of 30S subunit of ribosome with mRNA (c) association of 30S mRNA with formyl-met- tRNA (d) association of 50S subunit of ribosome with initiation complex.
Last Answer : (c) association of 30S mRNA with formyl-met- tRNA
Description : .During translation initiation in prokaryotes, a GTP molecule is needed in (a) formation of formyl-met-tRNA (b) binding of 30S subunit of ribosome with mRNA (c) association of 30S mRNA with formyl-met- tRNA (d) association of 50S subunit of ribosome with initiation complex.
Description : A characteristic of protein synthesis in both the archaea and eukarya is A.transcription and translation are coupled B.translation is inhibited by diphtheria toxin C.proteins are synthesized from D-, ... L-, isomers of amino acids D.the initiator tRNA is charged with N-formyl- methionine
Last Answer : C.proteins are synthesized from