Liver disease occurs when the liver is no longer able to properly perform normal functions and is usually a sign that the liver is about to fail. In most cases, around 75 percent of the liver is damaged or unable to function before signs and symptoms of the disease start to occur. Recognizing the signs is an important part of getting treatment.Pain and SwellingA potential sign of liver disease is pain in the upper right quadrant of the abdominal region, or the upper right area of the torso. In some situations, this pain is accompanied by swelling in the same area. The pain and swelling are serious signs of liver disease and require immediate medical attention.In most cases, the pain related to liver disease is severe and persistent. A brief pain that does not persist is usually not a sign of liver disease. Only a doctor can determine the exact cause, so it is important to discuss any upper abdominal pain not related to exercise with a medical doctor as soon as possible.Yellowing Skin and EyesYellowing of the skin and eyes, or jaundice, is the most common sign of liver disease. This occurs in almost every form of liver disease, including hepatitis. Jaundice is usually easy to recognize when it first develops and is a sign of severe liver damage. In some situations, the liver can heal and function normally after regular treatment.Appetite and FatigueChronic fatigue, changes to appetite and nausea are common signs of the problem that might or might not be related to liver disease. In many situations, doctors will run tests for other potential problems like anemia as well as tests for the liver if these signs stand alone.Appetite changes and fatigue that come with jaundice or pain in the upper abdominal region are clear signs of a liver problem. Doctors will usually run blood tests to determine the exact problem.Liver disease is a serious problem. It can result in liver failure, inefficient waste removal and sometimes even death if it is not treated.