A 2009 Altima ranges from 23 to 32 miles per gallon, while a 2010 Nissan Altima V6 gets between 18 MPG (city) to 27 MPG (highway). The 2010 Altima Hybrid's mileage per gallon goes from 42 to 36. The 4-cylinder 2010 Nissan Altima gets 23 city MPG and 32 highway MPG. The Altima hybrid gets 35 city MPG and 33 highway MPG. The Altima's start at $19,900.