DefinitionDisseminated histoplasmosis is a fungal infection that occurs after inhaling the spores of the fungus Histoplasma capsulatum.See also:HistoplasmosisHistoplasmosis - acuteHistoplasmosis - chronic pulmonarySkin lesion of histoplasmosisAlternative NamesSystemic histoplasmosisCauses, incidence, and risk factorsHistoplasmosis is caused by a fungus found in the central and eastern United States (Mississippi and Ohio River Valley), eastern Canada, Mexico, Central America, South America, Africa, and Southeast Asia.Most cases are mild or without symptoms. Acute pulmonary histoplasmosis may occur in epidemics after heavy exposure. Progressive or spreading (disseminated) and chronic disease can also occur. In disseminated disease, the infection has spread to other organs from the lungs thro