DefinitionCentral Diabetes insipidus is a rare condition that involves extreme thirst and excessive urination.See also: Diabetes insipidus - nephrogenicAlternative NamesCentral diabetes insipidusCauses, incidence, and risk factorsCentral diabetes insipidus occurs when the body has too little of the hormone vasopressin.Vasopressin limits the amount of urine the body produces. Normally, the hypothalamus gland in the brain makes vasopressin, and the pituitary gland stores the hormone. Without vasopressin, the kidneys do not work properly to keep enough water in the body. The result is a rapid loss of water from the body in the form of dilute urine. A person with diabetes insipidus needs to drink large quantities of water, driven by extreme thirst, to make up for this excessive water loss in t