An accurage Lethal Dose for the drug Zopiclone in humans doesnot seem to be currently available. This information may beuseful.History: A 72-year-old hospitalized male diedfollowing an intentional overdose of 90 milligrams ofzopiclone. The patient was being treated for lung cancerand died approximately 4 to 10 hours after the ingestion(Meatherall, 1997). The authors suggested this may be aminimum lethal dose considering the patient's age,weakened condition and arteriosclerosis.Meatherall RC: Zopiclone fatality in a hospitalizedpatient. J Forensic Sci. 1997; 42(2):340-3.LD50/LC50 - ANIMAL DATA - ZOPICLONELD50 - (ORAL) RAT: 827 mg/kgLD50 - (IM) RAT: 295 mg/kgLD50 - (IV) RAT: 280 mg/kgLD50 - (SC) RAT: 540 mg/kgLD50 - (ORAL) MOUSE: 2174 mg/kgLD50 - (IM) MOUSE: 541 mg/kgLD50 - (IV) MOUSE: 321 mg/kgLD50 - (SC) MOUSE: 888 mg/kgSource: RTECS Registry of Toxic Effects of ChemicalSubstances.National Institute for Occupational Safety and ealth,Cincinnati, O (internet Version). Micromedex Inc.,Greenwood Village, CO, 2001.I can tell u that during my drug abuse days I once did 58 7.5 mgpills so 435mg and blackedout. I woke up after I'm not sure howmany hours of "sleep" and found i could barely think and standingup was impossible. I'm 21 and 186lbs so it all depends. Worst partabout it after the first 8 pills i didnt even realize i was hurtingmyself or think of the possibilites. Zopiclonse really impairs u ijust kept taking more and more