If all are drug store quality then no. But if you are comparing Pantene to Redken, yes! A lot of the drug store varieties will use additional fillers that can be damaging to your hair like alcohols or sulfites, and the pH will be more damaging as well. Beware though, some ritzy brands will try to use the same tricks. Your best bet is to read the labels and go with a reputable brand i.e. Aveda, Biolage, Redken, etc. You can always ask your stylist what they recommend as well.