It’s ok for some meds and not for others. You can always ask the pharmacist or call the drug company. A basic rule is don’t open up capsules, but even with capsules it’s sometimes ok. Crushing an excedrin is fine, just be sure to eat with it a little and plenty of water. There is liquid Tylenol and liquid ibuprofen so you can make liquid excedrin yourself. Just read how many milligrams in a dose and measure it out and drink a coffee or Coke with it. Excedrin actually has aspirin not ibuprofen I think, so if you want exactly the drug in excedrin you can buy chewable aspirin. It comes in many flavors usually in the children’s/heart disease dose. You just take three or four of them. Again, just look at the ingredients. Even with chewable aspirin be sure to drink plenty of water. Having a little food wth it is good too, even if it’s just a cracker.