Down syndrome - what might it be?

In some sufferers of Down syndrome, the somatic cell nuclei do not contain three chromosomes number 21.There is a chromosomal defect relating to chromosome number 21; what might it be? 
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1 Answer

Answer :

A fragment, usually the short arm, of chromosome 21 is translocated onto another chromosome; thus, there are three copies of a fragment of the short arm in any one cell. This is a relatively rare occurrence.  
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