Description : The following occur in untreated insulin dependent diabetes mellitus: a. diuresis b. decreased plasma amino acid c. increased plasma fatty acid d. ketonuria
Last Answer : ketonuria
Description : Two conditions in which gluconeogenesis is increased are (A) Diabetes mellitus and atherosclerosis (B) Fed condition and thyrotoxicosis (C) Diabetes mellitus and Starvation (D) Alcohol intake and cigarette smoking
Last Answer : C
Description : Gluconeogenesis is increased in the following condition: (A) Diabetes insipidus (B) Diabetes Mellitus (C) Hypothyroidism (D) Liver diseases
Last Answer : B
Description : An enzyme involved in gluconeogenesis is (A) Pyruvate kinase (B) Pyruvate carboxylase (C) Hexokinase (D) Phosphohexose isomerase
Last Answer : Answer : B
Description : Which one of the following is a rate limiting enzyme of gluconeogenesis? (A) Hexokinase (B) Phsophofructokinase (C) Pyruvate carboxylase (D) Pyruvate kinase
Description : The 4 rate limiting enzymes of gluconeogenesis are (A) Glucokinase, Pyruvate carboxylae phosphoenol pyruvate carboxykinase and glucose-6-phosphatase (B) Pyruvate carboxylase, phosphoenol ... fructokinase, pyruvate carboxylase, phosphoenol pyruvate carboxykinase and fructose 1, 6 diphosphatase
Description : Mitochondrial lipogenesis requires (A) bicarbonate (B) biotin (C) acetyl CoA carboxylase (D) NADPH
Last Answer : Answer : D
Description : Which of the following statement(s) is/are true concerning metabolic derangements in sepsis and the systemic inflammatory response syndrome which may follow progressive shock? a. Alterations in glucose ... The serum aromatic amino acids fall rapidly as they are actively used in oxidative metabolism
Last Answer : Answer: b, c A broad spectrum of metabolic abnormalities become apparent in sepsis and the systemic inflammatory response syndrome following shock. Disruption of the normal cycles of carbohydrate, ... acetyl coenzyme A. This results in reduced serum level of leucine, isoleucine and valine
Description : Diabetes mellitus can occur due to all of the following except (A) Deficient insulin secretion (B) Tumour of β−cells (C) Decrease in number of insulin receptors (D) Formation of insulin antibodies
Description : In ad ipose t issue prostag land ins decrease (A) Lipogenesis (B) Lipolysis (C) Gluconeogenesis (D) Glycogenolysis
Last Answer : Answer : A
Description : Synthesis of Glucose from amino acids is termed as (A) Glycolysis (B) Gluconeogenesis (C) Glycogenesis (D) Lipogenesis
Description : Glucocorticoids increase the synthesis of all of the following except (A) Glucokinase (B) Glucose-6-phosphatase (C) Fructose-1, 6-biphosphatase (D) Pyruvate carboxylase
Description : Glucose tolerance is decreased in (A) Diabetes mellitus (B) Hypopituitarisme (C) Addison’s disease (D) Hypothyroidism
Last Answer : A
Description : Specific gravity of urine is decreased in (A) Diabetes mellitus (B) Acute glomerulonephritis (C) Diarrhoea (D) Chronic glomerulonephritis
Description : Renal threshold for glucose is decreased in (A) Diabetes mellitus (B) Insulinoma (C) Renal glycosuria (D) Alimentary glycosuria
Description : A 16 year old male with a day history of malaise, weakness and vomiting. He was diagnosed with Insulin dependent diabetes mellitus 3 years prviously. Which ONE of the following supports a diagnosis of ... serum glucose 14 mmol/l 4) Decreased appetite in the past few days 5) Shallow respirations
Last Answer : Answers-2 a-An unusual but recognised feature particularly in children. However does not support a diagnosis of DKA. b-Suggests metabolic acidosis. c-'Normoglycaemic DKA' can occur and a glucose ... anorexia. e-Respiratory compensation leads to rapid deep (Kussmaul's) breathing. (Dr Mike Mulcahy)
Description : Oedema can occur when (A) Plasma Na and Cl are decreased (B) Plasma Na and Cl are increased (C) Plasma proteins are decreased (D) Plasma proteins are increased
Last Answer : Answer : C
Description : Growth hormone causes hyperglycemia. It is a result of (A) Decreased peripheral utilization of glucose (B) Decreased hepatic production via gluconeogenesis (C) Increased glycolysis in muscle (D) Decrersed lipolysis
Description : Plasma bicarbonate is decreased in (A) Respiratory alkalosis (B) Respiratory acidosis (C) Metabolic alkalosis (D) Metabolic acidosis
Description : An 16-year-old man presents with polyuria and polydipsia. Which of the following may confirm the diagnosis of diabetes mellitus? 1) A random plasma glucose of >7.5 mmol/L 2) A finding of 3+ ketonuria 3) An HbA1c of 7.0% 4) A fasting plasma glucose of 7.5 mmol/L 5) An abnormal glucose tolerance test
Last Answer : Answers-4 The diagnosis is usually relatively easy to confirm in a symptomatic subject. A random glucose of >11.1 mmol/L or a fasting glucose of >7.0 mmol/L would be regarded as ... haemoglobin (HbA1c) is also highly suggestive but not diagnostic. A glucose tolerance test is rarely needed.
Description : Which of the following metabolic effects may be observed in patients with sepsis? a. Increased gluconeogenesis b. Accelerated proteolysis c. Increased lipolysis d. Impaired gut metabolism of glutamine
Last Answer : Answer: a, b, c, d A number of metabolic responses to sepsis have been defined. Glucose production is increased in infected patients which appears to be additive to the ... metabolism of lipids from peripheral fat stores is especially prominent during a period of inadequate nutritional support
Description : The ‘free fatty acids’ (FFA) of plasma: (A) metabolically inert (B) mainly bound to β-lipoproteins (C) stored in the fat (D) mainly bound to serum albumin
Description : During compensation of respiratory alkalosis, all the following changes occur except (A) Decreased secretion of hydrogen ions by renal tubules (B) Increased excretion of sodium in urine (C) Increased excretion of bicarbonate in urine (D) Increased excretion of ammonia in urine
Description : All the following changes in blood chemistry can occur in severe diarrhoea except (A) Decreased pH (B) Decreased bicarbonate (C) Increased pCO2 (D) Increased chloride WATER AND ELECTROLYTE BALANCE 287
Description : All of the following occur in orotic aciduria except (A) Increased synthesis of pyrimidine nucleotides (B) Increased excretion of orotic acid in urine (C) Decreased synthesis of cytidine triphosphate (D) Retardation of growth
Description : Which one of the following would be expected in pyruvate kinase deficiency? (A) Increased levels of lactate in the R.B.C (B) Hemolytic anemia (C) Decreased ratio of ADP to ATP in R.B.C (D) Increased phosphorylation of Glucose to Glucose-6-phosphate
Description : Compared to the resting state, vigorously contracting muscle shows (A) An increased conversion of pyruvate to lactate (B) Decreased oxidation of pyruvate of CO2 and water (C) A decreased NADH/NAD+ ratio (D) Decreased concentration of AMP CARBOHYDRATES AND CARBOHYDRATE METABOLISM 21
Description : Deficiency of magnesium may occur with (A) Alcoholism (B) Diabetes mellitus (C) Hypothyroidism (D) Advanced renal failure
Description : Hypoglycaemic coma can occur (A) In untreated diabetes mellitus (B) In starvation (C) After overdose of oral hypoglycaemic drugs (D) After overdose of insulin
Description : Oliguria can occur in (A) Diabetes mellitus (B) Diabetes insipidus (C) Acute glomerulonephritis (D) Chronic glomerulonephritis
Description : Hypocholesterolaemia can occur in (A) Hyperthyroidism (B) Nephrotic syndrome (C) Obstructive jaundice (D) Diabetes mellitus FATS AND FATTY ACID METABOLISM 89
Description : Polyuria can occur in (A) Diabetes mellitus (B) Diarrhoea (C) Acute glomerulonephritis (D) High fever
Description : Urinary water loss is increased in (A) Diabetes mellitus (B) Diabetes insipidus (C) Chronic glomerulonephritis (D) All of these
Description : The rate of HMP shunt reactions is (A) Increased by Insulin (B) Increased in diabetes mellitus (C) Increased by glucagons (D) Increased in starvation
Description : Glucose tolerance is increased in (A) Diabetes mellitus (B) Adrenalectomy (C) Acromegaly (D) Thyrotoxicosis
Description : In diabetes mellitus, non-esterified fatty acid level in blood is increased, why?
Last Answer : Insulin inhibits hormone sensitive lipase, in diabetes, this inhibition is removed, so, more lipolysis is taking place.
Description : Hyperglycemic effect of glucocorticoids is due to (A) Inactivation of protein phosphatase (B) Inactivation of fructose 1,6-biphosphatase (C) Stimulation of synthesis of pyruvate carboxylase (D) Stimulation of synthesis of eltroxykinase
Description : Mitochondrial pyruvate carboxylase contains (A) Zinc (B) Zinc (C) Manganese (D) Magnesium
Description : In conversion of lactic acid to glucose, three reactions of glycolytic pathway are circumvented, which of the following enzymes do not participate? (A) Pyruvate carboxylase (B) Phosphoenol pyruvate carboxy kinase (C) Pyruvate kinase (D) Glucose-6-phosphatase
Description : Biotin is a coenzyme for (A) Pyruvate dehydrogenase (B) Pyruvate carboxylase (C) PEP carboxykinase (D) Glutamate pyruvate transminase
Description : Jamaican vomiting sickness is due to inactivation of the enzyme (A) Pyruvate carboxylase (B) Acyl-Co-A synthetase (C) Acyl-Co-A dehydrogense (D) Thiolase
Description : The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase
Description : Carboxylation of acetyl-CoA to malonylCoA requires the enzyme: (A) Acetyl-CoA carboxylase (B) Pyruvate carboxylase (C) Acetyl transacylase (D) Acyl CoA-synthetase
Description : In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is (A) Acetyl CoA (B) Succinate (C) Isocitrate (D) Citrate
Description : The enzyme pyruvate carboxylase is present in (A) Cytosol (B) Mitochondria (C) Nucleus (D) Golgi bodies
Description : Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin
Description : Biotin is a coenzyme for (A) Pyruvate carboxylase (B) Acetyl CoA carboxylase (C) Propionyl CoA carboxylase (D) All of these
Description : In presence of the following cofactor, pyruvate carboxylase converts pyruvate to oxaloacetate: (A) ATP, Protein and CO2 (B) CO2 and ATP (C) CO2 (D) Protein
Description : Which of the following compound is a positive allosteric modifier of the enzyme pyruvate carboxylase? (A) Biotin (B) Acetyl CoA (C) Oxaloacetate (D) ATP
Description : In conversion of Lactic acid to Glucose, three reactions of Glycolytic pathway are circumvented, which of the following enzymes do not participate? (A) Pyruvate Carboxylase (B) Phosphoenol pyruvate carboxy kinase (C) Pyruvate kinase (D) Glucose-6-phosphatase