The concentration of sphingomyelins are increased in (A) Gaucher’s disease (B) Fabry’s disease (C) Fabrile disease (D) Niemann-Pick disease

The concentration of sphingomyelins are increased in (A) Gaucher’s disease (B) Fabry’s disease (C) Fabrile disease (D) Niemann-Pick disease
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Answer : B
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Inherited deficiency of enzyme cerebrosidase produces (A) Fabry’s disease (B) Niemann pick disease (C) Gaucher’s disease (D) Tay-sach’s disease

Description : Inherited deficiency of enzyme cerebrosidase produces (A) Fabry’s disease (B) Niemann pick disease (C) Gaucher’s disease (D) Tay-sach’s disease

Last Answer : Answer : C

Hexosaminidase A is deficient in (A) Tay-Sachs disease (B) Gaucher’s disease (C) Niemann-Pick disease (D) Fabry’s disease

Description : Hexosaminidase A is deficient in (A) Tay-Sachs disease (B) Gaucher’s disease (C) Niemann-Pick disease (D) Fabry’s disease

Last Answer : Answer : A

Mental retardation occurs in (A) Tay-Sachs disease (B) Gaucher’s disease (C) Niemann-Pick disease (D) All of these

Description : Mental retardation occurs in (A) Tay-Sachs disease (B) Gaucher’s disease (C) Niemann-Pick disease (D) All of these

Last Answer : Answer : D

β -Galactosidase is deficient in (A) Fabry’s disease (B) Krabbe’s disease (C) Gaucher’s disease (D) Metachromatic leukodystrophy

Description : β -Galactosidase is deficient in (A) Fabry’s disease (B) Krabbe’s disease (C) Gaucher’s disease (D) Metachromatic leukodystrophy

Last Answer : Answer : B

Niemann-Pick disease is due to deficiency of the enzyme (A) Ceramidase (B) Glucocerebrosidase (C) Galactocerebrosidase (D) Sphingomyelinase

Description : Niemann-Pick disease is due to deficiency of the enzyme (A) Ceramidase (B) Glucocerebrosidase (C) Galactocerebrosidase (D) Sphingomyelinase

Last Answer : Answer : D

Niemann-Pick disease results from deficiency of (A) Ceramidase (B) Sphingomyelinase (C) Arylsulphatase A (D) Hexosaminidase A

Description : Niemann-Pick disease results from deficiency of (A) Ceramidase (B) Sphingomyelinase (C) Arylsulphatase A (D) Hexosaminidase A

Last Answer : Answer : B

Niemann-Pick disease?

Description : Niemann-Pick disease?

Last Answer : DefinitionNiemann-Pick disease refers to a group of diseases passed down through families (inherited) in which fatty substances called lipids collect in the cells of the spleen, liver, and brain.There ... cells in the body lack an enzymecalled acid sphingomyelinase (ASM). ASM helps break down (me

Ceramidase is deficient in (A) Fabry’s disease (B) Farber’s disease (C) Krabbe’s disease (D) Tay-Sachs disease

Description : Ceramidase is deficient in (A) Fabry’s disease (B) Farber’s disease (C) Krabbe’s disease (D) Tay-Sachs disease

Last Answer : Answer : B

The enzyme ceramidase is deficient in (A) Farber’s disease (B) Fabry’s disease (C) Sandhoff’s disease(D) Refsum’s disease

Description : The enzyme ceramidase is deficient in (A) Farber’s disease (B) Fabry’s disease (C) Sandhoff’s disease(D) Refsum’s disease

Last Answer : Answer : A

α-Galactosidase enzyme is defective in (A) Tay-sach’s disease (B) Refsum’s disease (C) Sandhoff’s disease (D) Fabry’s disease

Description : α-Galactosidase enzyme is defective in (A) Tay-sach’s disease (B) Refsum’s disease (C) Sandhoff’s disease (D) Fabry’s disease

Last Answer : Answer : D

Serum ferroxidase level decreases in (A) Gaucher’s disease (B) Cirrhosis of liver (C) Acute pancreatitis (D) Wilson’s disease ENZYMES 143

Description : Serum ferroxidase level decreases in (A) Gaucher’s disease (B) Cirrhosis of liver (C) Acute pancreatitis (D) Wilson’s disease ENZYMES 143

Last Answer : Answer : D

Serum lipase level increases in (A) Paget’s disease (B) Gaucher’s disease (C) Acute pancreatitis (D) Diabetes mellitus

Description : Serum lipase level increases in (A) Paget’s disease (B) Gaucher’s disease (C) Acute pancreatitis (D) Diabetes mellitus

Last Answer : Answer : C

Fabry’s disease is due to the deficiency of the enzyme: (A) Ceramide trihexosidase (B) Galactocerebrosidase (C) Phytanic acid oxidase (D) Sphingomyelinase

Description : Fabry’s disease is due to the deficiency of the enzyme: (A) Ceramide trihexosidase (B) Galactocerebrosidase (C) Phytanic acid oxidase (D) Sphingomyelinase

Last Answer : Answer : A

Gaucher’s disease is due to the deficiency of the enzyme: (A) α-Fucosidase (B) β-Galactosidase (C) β-Glucosidase (D) Sphingomyelinase

Description : Gaucher’s disease is due to the deficiency of the enzyme: (A) α-Fucosidase (B) β-Galactosidase (C) β-Glucosidase (D) Sphingomyelinase

Last Answer : Answer : C

The enzyme deficient in Fabry’s disease is (A) α-Galactosidase (B) β-Galactosidase (C) α-Glucosidase (D) β-Glucosidase

Description : The enzyme deficient in Fabry’s disease is (A) α-Galactosidase (B) β-Galactosidase (C) α-Glucosidase (D) β-Glucosidase

Last Answer : Answer : A

Gaucher’s disease is due to deficiency of the enzyme: (A) Sphingomyelinase (B) Glucocerebrosidase (C) Galactocerbrosidase (D) β-Galactosidase

Description : Gaucher’s disease is due to deficiency of the enzyme: (A) Sphingomyelinase (B) Glucocerebrosidase (C) Galactocerbrosidase (D) β-Galactosidase

Last Answer : Answer : B

An important finding of Fabry’s disease is (A) Skin rash (B) Exophthalmos (C) Hemolytic anemia (D) Mental retardation

Description : An important finding of Fabry’s disease is (A) Skin rash (B) Exophthalmos (C) Hemolytic anemia (D) Mental retardation

Last Answer : Answer : A

Protein deficiency disease is known as (A) Cushing’s disease (B) Fabry’s disease (C) Parkinson’s disease (D) Kwashiorkor and marasmus

Description : Protein deficiency disease is known as (A) Cushing’s disease (B) Fabry’s disease (C) Parkinson’s disease (D) Kwashiorkor and marasmus

Last Answer : Answer : D

Inherited deficiency of β−glucosidase causes (A) Tay-Sachs disease (B) Metachromatic leukodystrophy (C) Gaucher’s disease (D) Multiple sclerosis

Description : Inherited deficiency of β−glucosidase causes (A) Tay-Sachs disease (B) Metachromatic leukodystrophy (C) Gaucher’s disease (D) Multiple sclerosis

Last Answer : Answer : C

Gaucher's Disease is associated with the deficiency of : 1) Hexosaminidase A 2) Sphingomyelinase 3) Arylsulphatase-A 4) B- Glucosidase 5) Iduronidase

Description : Gaucher's Disease is associated with the deficiency of : 1) Hexosaminidase A 2) Sphingomyelinase 3) Arylsulphatase-A 4) B- Glucosidase 5) Iduronidase

Last Answer : Answers-4 Hexosaminidase A deficiency is associated Tay-Sachs disease. Sphingomyelinase deficiency is associated with Niemann-Pick disease. Arylsulphatase-A deficiency is associated with metachromic leucodystrophy.Iduronidase deficiency is associated with Hurlers syndrome.

Sphingomyelins on hydrolysis yields (A) Glycerol, fatty acids, phosphoric acid and choline (B) Glycerol, sphingosine, choline and fatty acids (C) Sphingosine, phosphoric acid, Glycerol and inositol (D) Sphingosine, fatty acids, phosphoric acid and choline

Description : Sphingomyelins on hydrolysis yields (A) Glycerol, fatty acids, phosphoric acid and choline (B) Glycerol, sphingosine, choline and fatty acids (C) Sphingosine, phosphoric acid, Glycerol and inositol (D) Sphingosine, fatty acids, phosphoric acid and choline

Last Answer : Answer : D

Sphingomyelins are composed of fatty acids, phosphoric acid and (A) Sphingosine and choline (B) Glycerol and sphingosine (C) Glycerol and Serine (D) Glycerol and Choline

Description : Sphingomyelins are composed of fatty acids, phosphoric acid and (A) Sphingosine and choline (B) Glycerol and sphingosine (C) Glycerol and Serine (D) Glycerol and Choline

Last Answer : Answer : A

The types of sphingomyelins are (A) 1 (B) 3 (C) 4 (D) 5

Description : The types of sphingomyelins are (A) 1 (B) 3 (C) 4 (D) 5

Last Answer : Answer : B

Sphingomyelins contain a complex amino alcohol named as (A) Serine (B) Lysolecithin (C) Sphingosine (D) Glycol

Description : Sphingomyelins contain a complex amino alcohol named as (A) Serine (B) Lysolecithin (C) Sphingosine (D) Glycol

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Sphingomyelins: (A) Phospholipids (B) Nitrolipids (C) Alcohols (D) None of these

Description : Sphingomyelins: (A) Phospholipids (B) Nitrolipids (C) Alcohols (D) None of these

Last Answer : Answer : A

Pick out the wrong statement: (A) Chemical reactions with high activation energy are very temperature sensitive (B) A flat velocity profile exists in a plug flow reactor (C) The residence time for all the elements of fluid in case of a P.F.R. need not be same (D) Half life of a reaction increases with increased initial concentration for reaction orders more than one

Description : Pick out the wrong statement: (A) Chemical reactions with high activation energy are very temperature sensitive (B) A flat velocity profile exists in a plug flow reactor (C) The residence ... D) Half life of a reaction increases with increased initial concentration for reaction orders more than one

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Markedly increased concentration responsible for kernicterus in hemolytic disease of the newborn. A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these

Description : Markedly increased concentration responsible for kernicterus in hemolytic disease of the newborn. A A. Unconjugated bilirubin B. Conjugated bilirubin C. Both D. None of these

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Down regulation is (A) Increased destruction of a hormone (B) Feed back inhibition of hormone secretion (C) Decreased concentration of a hormone in blood (D) Decrease in number of receptors for a hormone

Description : Down regulation is (A) Increased destruction of a hormone (B) Feed back inhibition of hormone secretion (C) Decreased concentration of a hormone in blood (D) Decrease in number of receptors for a hormone

Last Answer : Answer : D

One of the potent st imu lators of aldosterone secretion is (A) Increased sodium concentration (B) Decreased potassium concentration (C) Increased potassium concentration (D) Increased ECF volume

Description : One of the potent st imu lators of aldosterone secretion is (A) Increased sodium concentration (B) Decreased potassium concentration (C) Increased potassium concentration (D) Increased ECF volume

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In competitive inhibition of enzyme action (A) The apparent Km is decreased (B) The apparent Km is increased (C) Vmax is decreased (D) Apparent concentration of enzyme molecules decreased

Description : In competitive inhibition of enzyme action (A) The apparent Km is decreased (B) The apparent Km is increased (C) Vmax is decreased (D) Apparent concentration of enzyme molecules decreased

Last Answer : Answer : B

In non-competitive enzyme action (A) Vmax is increased (B) Apparent km is increased (C) Apparent km is decreased (D) Concentration of active enzyme molecule is reduced

Description : In non-competitive enzyme action (A) Vmax is increased (B) Apparent km is increased (C) Apparent km is decreased (D) Concentration of active enzyme molecule is reduced

Last Answer : Answer : C

In reversible non-competitive enzyme activity inhibition (A) Vmax is increased (B) Km is increased (C) Km is decreased (D) Concentration of active enzyme is reduced

Description : In reversible non-competitive enzyme activity inhibition (A) Vmax is increased (B) Km is increased (C) Km is decreased (D) Concentration of active enzyme is reduced

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Concentration of pyruvic acid and lactic acid in blood is increased due to deficiency of the vitamin (A) Thiamin (B) Riboflavin (C) Niacin (D) Pantothenic acid

Description : Concentration of pyruvic acid and lactic acid in blood is increased due to deficiency of the vitamin (A) Thiamin (B) Riboflavin (C) Niacin (D) Pantothenic acid

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In allergic diseases, the concentration of the following is increased in plasma: (A) IgA (B) IgG (C) IgD (D) IgE

Description : In allergic diseases, the concentration of the following is increased in plasma: (A) IgA (B) IgG (C) IgD (D) IgE

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Familial hypertriaacylglycerolemia is associated with (A) Over production of VLDL (B) Increased LDL concentration (C) Increased HDL concentration (D) Slow clearance of chylomicrons

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Compared to the resting state, vigorously contracting muscle shows (A) An increased conversion of pyruvate to lactate (B) Decreased oxidation of pyruvate of CO2 and water (C) A decreased NADH/NAD+ ratio (D) Decreased concentration of AMP CARBOHYDRATES AND CARBOHYDRATE METABOLISM 21

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Last Answer : A

Which one of the following is true of IgE? 1) Is present in plasma in the same concentration as IgG 2) Is increased acutely in an asthmatic attack 3) Crosses the normal placenta 4) Is increased in the serum of atopic individuals 5) Is involved in type 2 hypersensitivity

Description : Which one of the following is true of IgE? 1) Is present in plasma in the same concentration as IgG 2) Is increased acutely in an asthmatic attack 3) Crosses the normal placenta 4) Is increased in the serum of atopic individuals 5) Is involved in type 2 hypersensitivity

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Plasma non-functional enzymes are (A) totally absent (B) low concentration in plastic (C) important for diagnosis of several disease (D) All of these

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All the following statements about cystic fibrosis are correct except (A) It is inherited as an autosomal recessive disease (B) It affects a number of exocrine glands (C) It causes increased sweating (D) Sweat chlorides are above 60 mEq/L in this disease

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Secretion of catecholamines is increased in (A) Cushing’s syndrome (B) Addison’s disease (C) Phaeochromocytoma (D) Simmond’s disease

Description : Secretion of catecholamines is increased in (A) Cushing’s syndrome (B) Addison’s disease (C) Phaeochromocytoma (D) Simmond’s disease

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Stature is increased in (A) Gigantism (B) Acromegaly (C) Simmond’s disease(D) Cushing’s disease

Description : Stature is increased in (A) Gigantism (B) Acromegaly (C) Simmond’s disease(D) Cushing’s disease

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BMR is increased in all of the following except (A) Hyperthyroidism (B) Anaemia (C) Addison’s disease (D) Pregnancy

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BMR is increased in (A) Starvation (B) Hypothyroidism (C) Addison’s disease (D) Pregnancy

Description : BMR is increased in (A) Starvation (B) Hypothyroidism (C) Addison’s disease (D) Pregnancy

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Which of the following statements about Menke’s disease are true. (A) It is an inherited disorder of copper metabolism (B) It occurs only in males (C) Plasma copper is increased in it (D) Hair becomes steely and kinky in it

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All the following statements about Wilson’s disease are correct except (A) It is a genetic disease (B) The defect involves copper-dependent P-type ATPase (C) Copper is deposited in liver, basal ganglia and around cornea (D) Plasma copper level is increased in it

Description : All the following statements about Wilson’s disease are correct except (A) It is a genetic disease (B) The defect involves copper-dependent P-type ATPase (C) Copper is deposited in liver, basal ganglia and around cornea (D) Plasma copper level is increased in it

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In Wilson’s disease (A) Copper fails to be excreted in the bile (B) Copper level in plasma is decreased (C) Ceruloplasmin level is increased (D) Intestinal absorption of copper is decreased

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The isozyme CK-MB is specifically increased in the blood of patients who had (A) Skeletal muscle disease (B) Recent myocardial infarction (C) Infective hepatitis (D) Myxoedema

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Pentosuria is a rare hereditary disease is characterized by increased urinary excretion of (A) L-xylulose (B) Xylitol (C) Xylulose 5-phosphate (D) Ribose 5-phosphate

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Last Answer : Answer : D