Which of the following features would be expected on lipid analysis in a 57 year old female with two year history of primary biliary cirrhosis? 1) A lipaemic appearance of the serum would be expected. 2) is treated with clofibrate therapy 3) is characteristically associated with tendon xanthomas 4) is characteristically associated with palmar xanthomas 5) No evidence of a dyslipidaemia would be expected with this short a duration of disease

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Answer :

Answers-4 In prolonged cholestasis features include: increased serum cholesterol, a moderate increase in triglyceride, the serum is not lipaemic, and reduced HDL levels. Clinical features include: palmar xanthomas; tuberous xanthomas (particularly on extensor surfaces); tendinous xanthomas are rare. Xanthomas usually only occur if cholestasis has persisted for more than 3 months sometimes fat deposits may involve bone and peripheral nerves.

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