For fast heartburn relief, you can use an item that you probably already have in your refrigerator. Baking soda can be used when you need heartburn relief fast, and don't want to wait for pills to kick in. Simply mix a heaping teaspoon with a small amount of water, about a quarter of a cup, and quickly drink it. The baking soda quickly neutralizes the acid in your body causing the pain, and you will feel better almost immediately.