A latex mattress can be valuable for many homeowners. It is waterproof, allowing for easy cleanup after a liquid spill. While most spills are easy to clean, some liquids can result in staining or a bad odor. To clean stains and prevent odor, use a baking soda and warm water solution. Mix 1 part baking soda to 5 parts warm water, and stir. Apply this solution across a latex mattress, allowing it to remain on stains for several minutes. Using a soft brush or rag, clean the stained areas using a clockwise motion. Make sure to rinse the latex mattress with water after cleaning.