DefinitionTertiary syphilis is a late phase of the sexually transmitted disease syphilis, caused by the spirochete Treponema pallidum.Alternative NamesLate syphilis; Tertiary syphilisCauses, incidence, and risk factorsSyphilis is a sexually transmitted, infectious disease caused by the spirochete Treponema pallidum.Syphilis has three main stages:Primary syphilisSecondary syphilisTertiary syphilisThis article focuses on tertiary syphilis. Tertiary syphilis can follow the initial infection (primary syphilis) by 3 to 15 years.In tertiary syphilis, the infection-causing organisms have continued to grow for years. Pockets of damage, or lesions, affects various tissues such as the bones, skin, nervous tissue, heart, and arteries. These areas are called gummas, and are very destructive.Tertiary s