False. It cannot be exergonic considering the nature of the pyranose ring, a strong structure that requires high pressures and temperatures in order to break it. There is a reference from 1995 [Glucose hydrolysis and oxidation in supercritical water. AIChE Journal, 41, 637 (1995)] where the authors detail the hydrolysis and oxidation of glucose in supercritical water at 246 bar and at 425 to 600ºC. On the other hand, in metabolic conditions, glucose undergoes the glycolysis pathway, a series of transformations from glucose to pyruvate in order to enter the Krebs cycle and to produce ATP in oxidative phosphorylations thereafter. The final balance of glycolysis (from glucose to ATP) is exergonic, that's the reason of why the body (in higher organisms) generates heat.