How is analyzing the inheritance patterns of sickle cell disease through pedigrees allowed scientists to determine that the disease is autosomal recessive?

How is analyzing the inheritance patterns of sickle cell disease through pedigrees allowed scientists to determine that the disease is autosomal recessive?
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Which type of Mendelian inherited condition results in both genders being affected equally in a vertical pattern? a) Automosomal dominant inheritance An individual who has an autosomal dominant inherited condition carries a gene mutation for that condition on one chromosome of a pair. b) Automosomal recessive inheritance The pattern of inheritance in autosomal recessive inherited conditions is different from that of autosomal dominant inherited conditions in that it is more horizontal than vertical, with relatives of a single generation tending to have the condition. c) X-linked inheritance X-linked conditions may be inherited in families in recessive or dominant patterns.

Description : Which type of Mendelian inherited condition results in both genders being affected equally in a vertical pattern? a) Automosomal dominant inheritance An individual who has an autosomal dominant ... that combine during early embryonic development leading to incomplete closure of the neural tube.

Last Answer : a) Automosomal dominant inheritance An individual who has an autosomal dominant inherited condition carries a gene mutation for that condition on one chromosome of a pair.

Pick out the correct statements. (1) Haemophilia is a sex-linked recessive disease. (2) Down’s syndrome is due to aneuploidy. (3) Phenylketonuria is an autosomal recessive gene disorder. (4) Sickle cell anaemia is an X-linked recessive gene disorder. (a) (1), (3) and (4) are correct. (b) (1), (2) and (3) are correct. (c) (1) and (4) are correct. (d) (2) and (4) are correct.

Description : Pick out the correct statements. (1) Haemophilia is a sex-linked recessive disease. (2) Down's syndrome is due to aneuploidy. (3) Phenylketonuria is an autosomal recessive gene disorder. (4) Sickle cell anaemia is an X- ... are correct. (c) (1) and (4) are correct. (d) (2) and (4) are correct.

Last Answer : (b) (1), (2) and (3) are correct.

Select the correct match. (a) Haemophilia – Y linked (b) Phenylketonuria – Autosomal dominant trait(c) Sickle cell anaemia – Autosomal recessive trait,chromosome -11 (d) Thalassemia – X linked

Description : Select the correct match. (a) Haemophilia – Y linked (b) Phenylketonuria – Autosomal dominant trait (c) Sickle cell anaemia – Autosomal recessive trait,chromosome -11 (d) Thalassemia – X linked

Last Answer : (c) Sickle cell anaemia – Autosomal recessive trait,chromosome -11

All of the following statements about Tangier disease are true except (A) It is a disorder of HDL metabolism (B) Its inheritance is autosomal recessive (C) Apoproteins A-I and A-II are not synthesised (D) Plasma HDL is increased

Description : All of the following statements about Tangier disease are true except (A) It is a disorder of HDL metabolism (B) Its inheritance is autosomal recessive (C) Apoproteins A-I and A-II are not synthesised (D) Plasma HDL is increased

Last Answer : Answer : D

A man and a woman, who do not show any apparent signs of a certain inherited disease, have seven children (2 daughters and 5 sons). Three of the sons suffer from the given disease but none of the daughters affected. Which of the following mode of inheritance do you suggest for this disease? (a) Sex-linked dominant (b) Sex-linked recessive (c) Sex-limited recessive (d) Autosomal dominant

Description : A man and a woman, who do not show any apparent signs of a certain inherited disease, have seven children (2 daughters and 5 sons). Three of the sons suffer from the given disease but none ... ? (a) Sex-linked dominant (b) Sex-linked recessive (c) Sex-limited recessive (d) Autosomal dominant

Last Answer : (b) Sex-linked recessive

Study the pedigree chart given below. What does it show? (a) Inheritance of a condition like phenylketonuria as an autosomal recessive trait. (b) The pedigree chart is wrong as this is not possible. (c) Inheritance of a recessive sex-linked disease like haemophilia. (d) Inheritance of a sex-linked inborn error of metabolism like phenylketonuria

Description : Study the pedigree chart given below. What does it show? (a) Inheritance of a condition like phenylketonuria as an autosomal recessive trait. (b) The pedigree chart is wrong as this is ... disease like haemophilia. (d) Inheritance of a sex-linked inborn error of metabolism like phenylketonuria

Last Answer : (a) Inheritance of a condition like phenylketonuria as an autosomal recessive trait.

In autosomal recessive inheritance: a. the rarer the trait the higher the possibility of marriages within the same family b. most recessive gene defects cause problem through failure to produce functional protein c. both males and females are affected equally severely d. all above

Description : In autosomal recessive inheritance: a. the rarer the trait the higher the possibility of marriages within the same family b. most recessive gene defects cause problem through failure to produce functional protein c. both males and females are affected equally severely d. all above

Last Answer : all above

What type of inheritance pattern (are the A and B alleles to each other (Autosomal dominant-Regular dominant-recessive relationship, X linked, co-dominant, incomplete dominant)?

Description : What type of inheritance pattern (are the A and B alleles to each other (Autosomal dominant-Regular dominant-recessive relationship, X linked, co-dominant, incomplete dominant)?

Last Answer : Incomplete dominance

All are true about lesch-nyhan syndrome except (A) Produces self-mutilation (B) Genetic deficiency of the enzyme (C) Elevated levels of uric acid in blood (D) Inheritance is autosomal recessive

Description : All are true about lesch-nyhan syndrome except (A) Produces self-mutilation (B) Genetic deficiency of the enzyme (C) Elevated levels of uric acid in blood (D) Inheritance is autosomal recessive

Last Answer : Answer : B

Inheritance of primary gout is (A) Autosomal recessive (B) Autosomal dominant (C) X-linked recessive (D) X-linked dominant

Description : Inheritance of primary gout is (A) Autosomal recessive (B) Autosomal dominant (C) X-linked recessive (D) X-linked dominant

Last Answer : Answer : C

Which of the following is a characteristic feature of acute intermittent porphyria? 1) autosomal recessive inheritance 2) excessive faecal protoporphyrin excretion 3) excessive urinary porphobilinigoen between acute attacks 4) hypernatraemia during attacks 5) photosensitivity

Description : Which of the following is a characteristic feature of acute intermittent porphyria? 1) autosomal recessive inheritance 2) excessive faecal protoporphyrin excretion 3) excessive urinary porphobilinigoen between acute attacks 4) hypernatraemia during attacks 5) photosensitivity

Last Answer : Answers-3 Features of acute intermittent porphyria include urinary porphobilinogen excretion raised between attacks, hyponatraemia during an acute attack and autosomal dominant inheritance.

Which of the following is true of Gilbert's syndrome? 1) inheritance is autosomal recessive 2) serum conjugated bilirubin levels are elevated 3) serum bilirubin levels are decreased by fasting 4) serum bilirubin levels are decreased by liver enzyme inducers 5) there is bilirubinuria

Description : Which of the following is true of Gilbert's syndrome? 1) inheritance is autosomal recessive 2) serum conjugated bilirubin levels are elevated 3) serum bilirubin levels are decreased by fasting 4) serum bilirubin levels are decreased by liver enzyme inducers 5) there is bilirubinuria

Last Answer : Answers-4 Gilbert's syndrome is inherited in autosomal dominant fashion and affects 2-5% of the population. UDP glucuronyl transferase levels are reduced leading to an unconjugated hyperbilirubinaemia. ... the bilirubin is reabsorbed in the proximal tubule some bilirubin is detectable in the urine.

.A disease caused by an autosomal primary non- disjunction is (a) Klinefelter’s syndrome (b) Turner’s syndrome (c) Sickle cell anaemia (d) Down’s syndrome.

Description : .A disease caused by an autosomal primary non- disjunction is (a) Klinefelter’s syndrome (b) Turner’s syndrome (c) Sickle cell anaemia (d) Down’s syndrome.

Last Answer : (d) Down’s syndrome.

Sickle cell anaemia has not been eliminated from the African population because (a) it is controlled by dominant genes (b) it is controlled by recessive genes (c) it is not a fatal disease (d) it provides immunity against malaria

Description : Sickle cell anaemia has not been eliminated from the African population because (a) it is controlled by dominant genes (b) it is controlled by recessive genes (c) it is not a fatal disease (d) it provides immunity against malaria

Last Answer : (d) it provides immunity against malaria.

. Sickle-cell anaemia is (a) caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin (b) caused by a change in a single base pair of DNA (c) characterized by elongated sickle like RBCs with a nucleus (d) an autosomal linked dominant trait.

Description : . Sickle-cell anaemia is (a) caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin (b) caused by a change in a single base pair of DNA (c) characterized by elongated sickle like RBCs with a nucleus (d) an autosomal linked dominant trait.

Last Answer : (b) caused by a change in a single base pair of DNA

All the following statements about cystic fibrosis are correct except (A) It is inherited as an autosomal recessive disease (B) It affects a number of exocrine glands (C) It causes increased sweating (D) Sweat chlorides are above 60 mEq/L in this disease

Description : All the following statements about cystic fibrosis are correct except (A) It is inherited as an autosomal recessive disease (B) It affects a number of exocrine glands (C) It causes increased sweating (D) Sweat chlorides are above 60 mEq/L in this disease

Last Answer : Answer : C

.A diseased man marries a normal woman. They get three daughters and five sons. All the daughters were diseased and sons were normal. The gene of this disease is (a) sex linked dominant (b) sex linked recessive (c) sex limited character (d) autosomal dominant.

Description : .A diseased man marries a normal woman. They get three daughters and five sons. All the daughters were diseased and sons were normal. The gene of this disease is (a) sex linked dominant (b) sex linked recessive (c) sex limited character (d) autosomal dominant.

Last Answer : (a) sex linked dominant

All the following statements about xeroderma pigmentosum are true except (A) It is a genetic disease (B) Its inheritance is autosomal dominant (C) uvr ABC excinuclease is defective in this disease (D) It results in multiple skin cancers

Description : All the following statements about xeroderma pigmentosum are true except (A) It is a genetic disease (B) Its inheritance is autosomal dominant (C) uvr ABC excinuclease is defective in this disease (D) It results in multiple skin cancers

Last Answer : Answer : B

Ataxia is the term that refers to a) uncoordinated muscle movement. Ataxia-telangiectasia is an autosomal recessive disorder affecting both T-cell and B-cell immunity.

Description : Ataxia is the term that refers to a) uncoordinated muscle movement. Ataxia-telangiectasia is an autosomal recessive disorder affecting both T-cell and B-cell immunity. b) vascular lesions ... to understand the spoken word. d) difficulty swallowing. Dysphagia refers to difficulty swallowing.

Last Answer : a) uncoordinated muscle movement. Ataxia-telangiectasia is an autosomal recessive disorder affecting both T-cell and B-cell immunity.

.Represented here is the inheritance pattern of a certain type of trait in humans. Which one of the following conditions could be an example of this pattern? (a) Phenylketonuria (b) Sickle cell anaemia (c) Haemophilia (d) Thalassemia

Description : .Represented here is the inheritance pattern of a certain type of trait in humans. Which one of the following conditions could be an example of this pattern? (a) Phenylketonuria (b) Sickle cell anaemia (c) Haemophilia (d) Thalassemia

Last Answer : (c) Haemophilia

A polygenic inheritance in human beings is (a) skin colour (b) phenylketonuria (c) colour blindness (d) sickle cell anaemia

Description : A polygenic inheritance in human beings is (a) skin colour (b) phenylketonuria (c) colour blindness (d) sickle cell anaemia

Last Answer : (a) skin colour

In human beings, multiple genes are involved in the inheritance of (a) sickle-cell anaemia (b) skin colour (c) colour blindness (d) phenylketonuria.

Description : In human beings, multiple genes are involved in the inheritance of (a) sickle-cell anaemia (b) skin colour (c) colour blindness (d) phenylketonuria.

Last Answer : ) skin colour

Multiple alleles control inheritance of (a) phenylketonuria (b) colour blindness (c) sickle cell anaemia (d) blood groups.

Description : Multiple alleles control inheritance of (a) phenylketonuria (b) colour blindness (c) sickle cell anaemia (d) blood groups.

Last Answer : (d) blood groups.

A genetically diseased father (male) marries with a normal female and gives birth to 3 carrier girls and 5 normal sons. It may be which type of genetic disease? (a) Sex-influenced disease (b) Blood group inheritance disease (c) Sex-linked disease (d) Sex-recessive disease

Description : A genetically diseased father (male) marries with a normal female and gives birth to 3 carrier girls and 5 normal sons. It may be which type of genetic disease? (a) Sex-influenced disease (b) Blood group inheritance disease (c) Sex-linked disease (d) Sex-recessive disease

Last Answer : (c) Sex-linked disease

Autosomal recessive?

Description : Autosomal recessive?

Last Answer : DefinitionAutosomal recessive is one of several ways that a trait, disorder, or disease can be passed down through families.An autosomal recessive disorder means two copies of an abnormal gene must be ... be defective to cause disease. People with only one defective gene in the pair are considered

An autosomal recessive disorder, xanthinuria is due to deficiency of the enzymes: (A) Adenosine deaminase (B) Xanthine oxidase (C) HGPRTase (D) Transaminase

Description : An autosomal recessive disorder, xanthinuria is due to deficiency of the enzymes: (A) Adenosine deaminase (B) Xanthine oxidase (C) HGPRTase (D) Transaminase

Last Answer : Answer : B

Albinism is known to be due to an autosomal recessive mutation. The first child of a couple with normal skin pigmentation was an albino. What is the probability that their second child will also be an albino? (a) 50% (b) 75% (c) 100% (d) 25%

Description : Albinism is known to be due to an autosomal recessive mutation. The first child of a couple with normal skin pigmentation was an albino. What is the probability that their second child will also be an albino? (a) 50% (b) 75% (c) 100% (d) 25%

Last Answer : (d) 25%

If both parents are carriers for thalassaemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child? (a) 25% (b) 100% (c) No chance (d) 50%

Description : If both parents are carriers for thalassaemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child? (a) 25% (b) 100% (c) No chance (d) 50%

Last Answer : 25%

n the following human pedigree, the filled symbols represent the affected individuals. Identify the type of given pedigree. (i) (ii) (iii) (iv) (a) Autosomal recessive (b) X-linked dominant (c) Autosomal dominant (d) X-linked recessive

Description : n the following human pedigree, the filled symbols represent the affected individuals. Identify the type of given pedigree. (i) (ii) (iii) (iv) (a) Autosomal recessive (b) X-linked dominant (c) Autosomal dominant (d) X-linked recessive

Last Answer : (a) Autosomal recessive

What is an autosomal dominant pattern of inheritance?

Description : What is an autosomal dominant pattern of inheritance?

Last Answer : Need answer

Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas

Description : Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas

Last Answer : Answers-1 Familial hypercholesterolaemia is an autosomal dominant condition manifest by increased LDL concentrations (not chylomicrons) due to constitutional abnormalities and reduced numbers of ... are characteristic and the condition is associated with a premature cardiovascular mortality.

Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas

Description : Which of the following is a characteristic feature of familial hypercholesterolaemia? 1) Autosomal dominant inheritance 2) elevated chylomicrons 3) hypertriglyceridaemia 4) increased expression of LDL receptors 5) Palmar xanthomas

Last Answer : Answers-1 Familial hypercholesterolaemia is an autosomal dominant condition manifest by increased LDL concentrations (not chylomicrons) due to constitutional abnormalities and reduced numbers of ... are characteristic and the condition is associated with a premature cardiovascular mortality.

Why are pedigrees helpful inunderstanding genetic disorders?

Description : Why are pedigrees helpful inunderstanding genetic disorders?

Last Answer : Need answer

All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be due to increased activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it

Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it

Last Answer : Answer : C

Which one is the incorrect statement with regard to the importance of pedigree analysis? (a) It confirms that DNA is the carrier of genetic information. (b) It helps to understand whether the trait in question is dominant or recessive. (c) It confirms that the trait is linked to one of the autosome. (d) It helps to trace the inheritance of a specific trait.

Description : Which one is the incorrect statement with regard to the importance of pedigree analysis? (a) It confirms that DNA is the carrier of genetic information. (b) It helps to understand whether the trait in ... linked to one of the autosome. (d) It helps to trace the inheritance of a specific trait.

Last Answer : (a) It confirms that DNA is the carrier of genetic information.

A disease caused by an autosomal primary non- disjunction is : (1) Klinefelter's Syndrome(2) Turner's Syndrome (3) Sickel Cell Anemia (4) Down's Syndrome

Description : A disease caused by an autosomal primary non- disjunction is : (1) Klinefelter's Syndrome(2) Turner's Syndrome (3) Sickel Cell Anemia (4) Down's Syndrome

Last Answer : (4) Down's Syndrome

Instincts study the inheritance patterns in traits that are handed down from parents to off-spring.

Description : Instincts study the inheritance patterns in traits that are handed down from parents to off-spring.

Last Answer : Correct the underlined words and complete the sentence : Instincts study the inheritance patterns in ... are handed down from parents to off-spring.

Why do-sex linked traits follow different patterns of inheritance than other traits?

Description : Why do-sex linked traits follow different patterns of inheritance than other traits?

Last Answer : Sexlinked traits follow a different pattern of inheritance thana non-sex linked trait because of the size difference between the Xand y chromosomes.Think about non-sex chormosomes as being the same size, eachhaving ... of the daughters will be carriers (Aa) and all the sons willbe normal (A-).

What are two inheritance patterns besides simple dominance?

Description : What are two inheritance patterns besides simple dominance?

Last Answer : Simple dominance, known as "complete dominance" is when oneallele is expressed over another (the recessive gene is notexpressed at all).Two other patterns are incomplete dominance and codominance.Incomplete dominance is ... and rr is white, Rr would be white with red spots (or redwith white spots).

In sickle cell disease variation of one gene causes?

Description : In sickle cell disease variation of one gene causes?

Last Answer : Feel Free to Answer

Sickle-cell anemia is a disease caused due to the abnormality in – (1) white blood cells (2) red blood cells (3) thrombocytes (4) blood plasma composition

Description : Sickle-cell anemia is a disease caused due to the abnormality in – (1) white blood cells (2) red blood cells (3) thrombocytes (4) blood plasma composition

Last Answer : (2) red blood cells Explanation: Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (the oxygencarrying protein within the red blood cells).

Which of the following is a correct match? (a) Down’s syndrome - 21st chromosome (b) Sickle cell anaemia - X-chromosome (c) Haemophilia - Y-chromosome (d) Parkinson’s disease - X and Y chromosome

Description : Which of the following is a correct match? (a) Down’s syndrome - 21st chromosome (b) Sickle cell anaemia - X-chromosome (c) Haemophilia - Y-chromosome (d) Parkinson’s disease - X and Y chromosome

Last Answer : a) Down’s syndrome - 21st chromosome

.Which one of the following conditions though harmful in itself, is also potential saviour from a mosquito borne infectious disease ? (a) Thalassaemia (b) Sickle cell anaemia (c) Pernicious anaemia (d) Leukaemia

Description : .Which one of the following conditions though harmful in itself, is also potential saviour from a mosquito borne infectious disease ? (a) Thalassaemia (b) Sickle cell anaemia (c) Pernicious anaemia (d) Leukaemia

Last Answer : (b) Sickle cell anaemia

The most striking example of point mutation is found in a disease called (a) Down’s syndrome (b) sickle cell anaemia (c) thalassaemia (d) night blindness.

Description : The most striking example of point mutation is found in a disease called (a) Down’s syndrome (b) sickle cell anaemia (c) thalassaemia (d) night blindness.

Last Answer : (b) sickle cell anaemia

Which one of the following statements is correct regarding sexually transmitted diseases (STDs)? (a) A person may contract syphilis by sharing milk with one already suffering from the disease. (b) Haemophilia is one of the STDs.(c) Genital herpes and sickle-cell anaemia are both STDs. (d) The chances of a 5-years boy contracting a STD are very little.

Description : Which one of the following statements is correct regarding sexually transmitted diseases (STDs)? (a) A person may contract syphilis by sharing milk with one already suffering from the disease. (b) Haemophilia is ... both STDs. (d) The chances of a 5-years boy contracting a STD are very little.

Last Answer : (d) The chances of a 5-years boy contracting a STD are very little.

Of the following hemolytic anemias, which is categorized as inherited? a) Sickle cell anemia Glucose 6-phosphate dehydrogenase deficiency is an inherited abnormality resulting in hemolytic anemia. b) Autoimmune hemolytic anemia Autoimmune hemolytic anemia is an acquired anemia. c) Cold agglutinin disease Cold agglutinin disease is an acquired anemia. d) Hypersplenism Hypersplenism results in an acquired hemolytic anemia.

Description : Of the following hemolytic anemias, which is categorized as inherited? a) Sickle cell anemia Glucose 6-phosphate dehydrogenase deficiency is an inherited abnormality resulting in hemolytic anemia. b ... is an acquired anemia. d) Hypersplenism Hypersplenism results in an acquired hemolytic anemia.

Last Answer : a) Sickle cell anemia Glucose 6-phosphate dehydrogenase deficiency is an inherited abnormality resulting in hemolytic anemia.

Sickle cell disease is inherited due to defective copies of _________gene. a. Heparin b. Haemoglobin c. Creatinine d. Fibrinogen

Description : Sickle cell disease is inherited due to defective copies of _________gene. a. Heparin b. Haemoglobin c. Creatinine d. Fibrinogen

Last Answer : b. Haemoglobin

When scientists observe weather patterns in the US in which direction do they find these patterns generally move?

Description : When scientists observe weather patterns in the US in which direction do they find these patterns generally move?

Last Answer : In general weather patterns move west to east, with theexception that weather patterns originating over the Caribbean movesouth to north up the east coast states.

What new instrument has allowed scientists to observe tbe smaller components within a cell?

Description : What new instrument has allowed scientists to observe tbe smaller components within a cell?

Last Answer : Need answer

Which of the following is a Dominant Autosomal Disorder? (1) Albinism (2) Cystic Fibrosis (3) Phenyl Ketorunia (4) Alzheimer's Disease

Description : Which of the following is a Dominant Autosomal Disorder? (1) Albinism (2) Cystic Fibrosis (3) Phenyl Ketorunia (4) Alzheimer's Disease

Last Answer : (4) Alzheimer's Disease Explanation: In an autosomal dominant disorder, the mutated gene is a dominant gene located on one of the nonsex chromosomes (autosomes). The early-onset form of Alzheimer ... the disorder. In most cases, an affected person inherits the altered gene from one affected parent.