Very much so. If your pets consume any of the vine, leaves included, even the smallest nibble, they will die is quite a bit of pain. Silver Lace Vine has the same effect on animals as Rat Poinson on humans! Its best that you place a fence around trhis plant, one that is tall enough to ensure that your pets cannot jump it, for their safety. By the way, the Department of Defense, used grinded up Silver Lace juice in the Viet Nam War, with great sucecss. -Birdy