Interactions between biomolecules depend on the forming and breaking of chemical bonds. The covalent bond is the strongest chemical bond. It links individual atoms within a molecule and involves sharing of a pair of electrons between adjacent atoms. Its formation requires considerable energy, and its breakage releases this energy. The formation and breakage of covalent bonds are not readily reversible processes. Noncovalent bonds are weaker and are often readily reversible. The four major ones differ in their length,strength, specificity, and response to water. Although noncovalent interactions are weaker than covalent bonds .