What is the significance of zymogen activation?

What is the significance of zymogen activation?
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Gastro-intestinal enzymes are synthesised in the form of pro-enzymes, and only after secretion into the alimentary canal, they are activated. This prevents autolysis of cellular structural proteins. Coagulation factors are seen in blood as zymogen form, their activation takes place only when necessity arises. This prevents intravascular coagulation.
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Related questions

Acute pancreatitis is characterised by (A) Lack of synthesis of zymogen enzymes (B) Continuous release of zymogen enzymes into the gut (C) Premature activation of zymogen enzymes (D) Inactivation of zymogen enzymes

Description : Acute pancreatitis is characterised by (A) Lack of synthesis of zymogen enzymes (B) Continuous release of zymogen enzymes into the gut (C) Premature activation of zymogen enzymes (D) Inactivation of zymogen enzymes

Last Answer : Answer : C

Zymogen is a (A) Vitamin (B) Enzyme precursor (C) Modulator (D) Hormone

Description : Zymogen is a (A) Vitamin (B) Enzyme precursor (C) Modulator (D) Hormone

Last Answer : Answer : B

The zymogen from trypsinogen of pancreatic juice is converted to active trypsin by (A) Peisin (B) Enterocrinin (C) Enterokinase (D) Rennin

Description : The zymogen from trypsinogen of pancreatic juice is converted to active trypsin by (A) Peisin (B) Enterocrinin (C) Enterokinase (D) Rennin

Last Answer : Answer : C

Zymogen is (A) An intracellular enzyme (B) Serum enzyme (C) A complete extracellular enzyme (D) An inactivated enzyme

Description : Zymogen is (A) An intracellular enzyme (B) Serum enzyme (C) A complete extracellular enzyme (D) An inactivated enzyme

Last Answer : Answer : D

Give an example of zymogen is activated?

Description : Give an example of zymogen is activated? 

Last Answer : By splitting a single peptide bond, and removal of a small polypeptide from trypsinogen, the active trypsin is formed. This results in unmasking of the active centre.

What is zymogen?

Description : What is zymogen?

Last Answer : It is otherwise called pro-enzyme. Inactive zymogen is activated by removal of a piece of the pro-enzyme.

HCI is secreted by (a) Zymogen cells (b) Peptic cell (c) Oxyntic cells (d) None of these

Description : HCI is secreted by (a) Zymogen cells (b) Peptic cell (c) Oxyntic cells (d) None of these

Last Answer : Ans:(c)

Epithelial cells of the intestine involved in food absorption have on their surface (a) pinocytic vesicles (b) microvilli (c) zymogen granules (d) phagocytic vesicles.

Description : Epithelial cells of the intestine involved in food absorption have on their surface (a) pinocytic vesicles (b) microvilli (c) zymogen granules (d) phagocytic vesicles.

Last Answer : (b) microvilli

In man the zymogen or chief cells are mainly found in (a) cardiac part of stomach (b) pyloric part of stomach (c) duodenum (d) fundic part of stomach.

Description : In man the zymogen or chief cells are mainly found in (a) cardiac part of stomach (b) pyloric part of stomach (c) duodenum (d) fundic part of stomach.

Last Answer : (d) fundic part of stomach.

Which cells of ‘Crypts of Lieberkuhn’ secrete antibacterial lysozyme? (a) Paneth cells (b) Zymogen cells (c) Kupffer cells (d) Argentaffin cells

Description : Which cells of ‘Crypts of Lieberkuhn’ secrete antibacterial lysozyme? (a) Paneth cells (b) Zymogen cells (c) Kupffer cells (d) Argentaffin cells

Last Answer : (a) Paneth cells

Which cells of "Crypts of Lieberkuhn" secrete antibacterial lysozyme ? (1) Paneth cells (2) Zymogen cells (3) Kupffer cells (4) Argentaffin cells

Description : Which cells of "Crypts of Lieberkuhn" secrete antibacterial lysozyme ? (1) Paneth cells (2) Zymogen cells (3) Kupffer cells (4) Argentaffin cells

Last Answer : (1) Paneth cells

Zymogen cells of gastric gland secrete (a) Pepsinogen (b) Chymotrypsin (c) Pepsin (d) Trypsin

Description : Zymogen cells of gastric gland secrete (a) Pepsinogen (b) Chymotrypsin (c) Pepsin (d) Trypsin

Last Answer : (a) Pepsinogen

Zymogen cell and chief cells secrete (a) HCI (b) Mucus (c) Pepsi (d) Trypsin

Description : Zymogen cell and chief cells secrete (a) HCI (b) Mucus (c) Pepsi (d) Trypsin

Last Answer : (c) Pepsi

Destruction of which of the following enzyme causes cyanide poisoning (a) Zymogen (b) Cytochrome enzyme (c) Urease (d) None of these

Description : Destruction of which of the following enzyme causes cyanide poisoning (a) Zymogen (b) Cytochrome enzyme (c) Urease (d) None of these

Last Answer : (b) Cytochrome enzyme

Zymogen cells are also called (a) Mast cells (b) Oxyntic cells (c) Chief cells (d) None of these

Description : Zymogen cells are also called (a) Mast cells (b) Oxyntic cells (c) Chief cells (d) None of these

Last Answer : (c) Chief cells

In how many different ways can the letters of the word "ZYMOGEN" be arranged in such a way that the vowels always come together? a) 1440 b) 1720 c) 2360 d) 2240

Description : In how many different ways can the letters of the word "ZYMOGEN" be arranged in such a way that the vowels always come together? a) 1440 b) 1720 c) 2360 d) 2240

Last Answer : Answer: A)  The arrangement is made in such a way that the vowels always come together. i.e., "ZYMGN(OE)". Considering vowels as one letter, 6 different letters can be arranged in 6! ways; i.e., 6! = 720 ... in 2! ways; i.e.,2! = 2 ways Therefore, required number of ways = 720 x 2 = 1440 ways.

Calcium is required for the activation of the enzyme: (A) Isocitrate dehydrogenase (B) Fumarase (C) Succinate thiokinase (D) ATPase

Description : Calcium is required for the activation of the enzyme: (A) Isocitrate dehydrogenase (B) Fumarase (C) Succinate thiokinase (D) ATPase

Last Answer : Answer : D

How many high-energy phosphate bond equivalents are required for amino acid activation in protein synthesis? (A) One (B) Two (C) Three (D) Four

Description : How many high-energy phosphate bond equivalents are required for amino acid activation in protein synthesis? (A) One (B) Two (C) Three (D) Four

Last Answer : Answer : B

Nonsense codons bring about (A) Amino acid activation (B) Initiation of protein synthesis (C) Termination of protein synthesis (D) Elongation of polypeptide chains

Description : Nonsense codons bring about (A) Amino acid activation (B) Initiation of protein synthesis (C) Termination of protein synthesis (D) Elongation of polypeptide chains

Last Answer : Answer : C

In the process of activation of amino acids for protein synthesis, the number of high energy phosphate bond equivalent utilised is (A) 0 (B) 1 (C) 2 (D) 4

Description : In the process of activation of amino acids for protein synthesis, the number of high energy phosphate bond equivalent utilised is (A) 0 (B) 1 (C) 2 (D) 4

Last Answer : Answer : C

Activation of IRS-1, PI-3 kinase and GRB2 is brought about by (A) Glucagon (B) Insulin (C) Prolactin (D) IGF-2

Description : Activation of IRS-1, PI-3 kinase and GRB2 is brought about by (A) Glucagon (B) Insulin (C) Prolactin (D) IGF-2

Last Answer : Answer : B

The energy required to start an enzymatic reaction is called (A) Chemical energy (B) Metabolic energy (C) Activation energy (D) Potential energy

Description : The energy required to start an enzymatic reaction is called (A) Chemical energy (B) Metabolic energy (C) Activation energy (D) Potential energy

Last Answer : Answer : C

An enzyme brings about (A) Decrease in reaction time (B) Increase in reaction time (C) Increase in activation energy (D) Reduction in activation energy

Description : An enzyme brings about (A) Decrease in reaction time (B) Increase in reaction time (C) Increase in activation energy (D) Reduction in activation energy

Last Answer : Answer : D

Enzymes increases the rate of reactions by (A) Increasing the free energy of activation (B) Decreasing the energy of activation (C) Changing the equilibrium constant of the reaction (D) Increasing the free energy change of the reaction

Description : Enzymes increases the rate of reactions by (A) Increasing the free energy of activation (B) Decreasing the energy of activation (C) Changing the equilibrium constant of the reaction (D) Increasing the free energy change of the reaction

Last Answer : Answer : B

An enzyme promotes a chemical reaction by (A) Lowering the energy of activation (B) Causing the release of heat which acts as a primer (C) Increasing molecular motion (D) Changing the free energy difference between substrate and product

Description : An enzyme promotes a chemical reaction by (A) Lowering the energy of activation (B) Causing the release of heat which acts as a primer (C) Increasing molecular motion (D) Changing the free energy difference between substrate and product

Last Answer : Answer : A

Enzymes increase the rates of reactions by (A) Increasing the free energy of activation (B) Decreasing the energy of activation (C) Changing the equilibrium constant of the reaction (D) Increasing the free energy change of the reaction

Description : Enzymes increase the rates of reactions by (A) Increasing the free energy of activation (B) Decreasing the energy of activation (C) Changing the equilibrium constant of the reaction (D) Increasing the free energy change of the reaction

Last Answer : Answer : B

Enzymes accelerate the rate of reactions by (A) Increasing the equilibrium constant of reactions (B) Increasing the energy of activation (C) Decreasing the energy of activation (D) Decreasing the free energy change of the reaction

Description : Enzymes accelerate the rate of reactions by (A) Increasing the equilibrium constant of reactions (B) Increasing the energy of activation (C) Decreasing the energy of activation (D) Decreasing the free energy change of the reaction

Last Answer : Answer : C

Isoenzymes can be characterized by (A) Proteins lacking enzymatic activity that are necessary for the activation of enzymes (B) Proteolytic enzymes activated by hydrolysis (C) Enzymes with identical primary structure (D) Similar enzymes that catalyse different reaction

Description : Isoenzymes can be characterized by (A) Proteins lacking enzymatic activity that are necessary for the activation of enzymes (B) Proteolytic enzymes activated by hydrolysis (C) Enzymes with identical primary structure (D) Similar enzymes that catalyse different reaction

Last Answer : Answer : B

Activation or inactivation of certain key regulatory enzymes is accomplished by covalent modification of the amino acid: (A) Tyrosine (B) Phenylalanine (C) Lysine (D) Serine

Description : Activation or inactivation of certain key regulatory enzymes is accomplished by covalent modification of the amino acid: (A) Tyrosine (B) Phenylalanine (C) Lysine (D) Serine

Last Answer : Answer : D

Which of the following regulates lipolysis in adipocytes? (A) Activation of fatty acid synthesis mediated by CAMP (B) Glycerol phosphorylation to prevent futile esterification of fatty acids (C) Activation of triglyceride lipase as a result of hormone stimulated increases in CAMP levels (D) Activation of CAMP production by Insulin

Description : Which of the following regulates lipolysis in adipocytes? (A) Activation of fatty acid synthesis mediated by CAMP (B) Glycerol phosphorylation to prevent futile esterification of fatty acids (C) ... result of hormone stimulated increases in CAMP levels (D) Activation of CAMP production by Insulin

Last Answer : Answer : C

For the activation of long chain fatty acids the enzyme thiokinase requires the cofactor: (A) Mg++ (B) Ca++ (C) Mn++ (D) K+

Description : For the activation of long chain fatty acids the enzyme thiokinase requires the cofactor: (A) Mg++ (B) Ca++ (C) Mn++ (D) K+

Last Answer : Answer : B

Activation of fatty acids requires all the following except (A) ATP (B) Coenzyme A (C) Thiokinase (D) Carnitine

Description : Activation of fatty acids requires all the following except (A) ATP (B) Coenzyme A (C) Thiokinase (D) Carnitine

Last Answer : Answer : D

The lipoprotein associated with activation of LCAT is (A) HDL (B) LDL (C) VLDL (D) IDL

Description : The lipoprotein associated with activation of LCAT is (A) HDL (B) LDL (C) VLDL (D) IDL

Last Answer : Answer : A

The difference between Threshold energy and average energy of the molecules is called activation energy. Ina chemical reaction lowers the rate of reaction the greater will be. The activation energy

Description : The difference between Threshold energy and average energy of the molecules is called activation energy. Ina chemical reaction lowers the rate of reaction the greater will be. The activation energy

Last Answer : How do you define the molecularity of a reaction ?

What is the mechanism of activation of hormone sensitive lipase?

Description : What is the mechanism of activation of hormone sensitive lipase?

Last Answer : A cascade through adenyl cyclase, cyclic AMP and kinase.

What is the enzyme for this activation?

Description : What is the enzyme for this activation?

Last Answer : Thiokinase or fatty acyl CoA synthetase.

On which day following acute myocardial infarction the estimation of serum AST will be of greatest significance? (A) First day (B) Second day (C) Third day (D) Fourth day

Description : On which day following acute myocardial infarction the estimation of serum AST will be of greatest significance? (A) First day (B) Second day (C) Third day (D) Fourth day

Last Answer : Answer : B

Pentose phosphate pathway is of significance because it generates (A) NADPH for reductive synthesis (B) Regenerates glucose 6-phosphate (C) Generates fructose 6-phosphate (D) Forms glyceraldehyde 3-phosphate

Description : Pentose phosphate pathway is of significance because it generates (A) NADPH for reductive synthesis (B) Regenerates glucose 6-phosphate (C) Generates fructose 6-phosphate (D) Forms glyceraldehyde 3-phosphate

Last Answer : Answer : A

What is the significance of lipoprotein (a)?

Description : What is the significance of lipoprotein (a)? 

Last Answer : Lp(a) is associated with heart attacks at the age of 30 or 40 years. Indians have a higher level of Lp(a) than Europeans.

What is the clinical significance of polyol pathway?

Description : What is the clinical significance of polyol pathway?

Last Answer : The elevated level of sorbitol has been implicated in the development of neuropathy, cataract and retinopathy in diabetes mellitus.

What is the clinical significance of transketolase enzyme?

Description : What is the clinical significance of transketolase enzyme?

Last Answer : The transketolase reaction is measured in RBCs as an index of the thiamine status of an individual.

What is the significance of glycated hemoglobin?

Description : What is the significance of glycated hemoglobin?

Last Answer : The determination of glycated hemoglobin is not for diagnosis of diabetes mellitus, but for monitoring the response of treatment. It is unaffected by recent food intake or recent ... . The risk of retinopathy and renal complications are proportionately increased with elevated glycatedhemoglobin.

What is the clinical significance of C peptide?

Description : What is the clinical significance of C peptide?

Last Answer : Sometimes measurement of endogenous insulin may be difficult because of the presence of antibodies against insulin in the circulation. Then measurement of C-peptide is useful.

What is the clinical significance of GDM?

Description : What is the clinical significance of GDM?

Last Answer : Women with GDM are at increased risk for subsequent development of frank diabetes. GDM is associated with increased birth weight of child and increased incidence of neonatal mortality.

What is the significance of gluconeogenesis?

Description : What is the significance of gluconeogenesis?

Last Answer : Gluconeogenesis is necessary to maintain blood glucose level especially under conditions of starvation.

What is the significance of Glycolysis?

Description : What is the significance of Glycolysis?

Last Answer : It is the only pathway that is taking place in all the cells of the body. Glycolysis is the only source of energy in erythrocytes. Moreover, anaerobic glycolysis forms the major source of energy in actively contracting muscles.

What is the significance of ALT?

Description : What is the significance of ALT?

Last Answer : Very high values are seen in acute hepatitis. Rise in ALT levels may be noticed several days before clinical signs such as jaundice are manifested. Moderate increase may be seen in chronic liver diseases such as cirrhosis, and malignancy in liver.

What is the significance of AST?

Description : What is the significance of AST?

Last Answer : It is significantly elevated in myocardial infarction and moderately elevated in liver diseases.

What is their clinical significance?

Description : What is their clinical significance?

Last Answer : Their normal levels in blood are very low, but are drastically increased during cell death (necrosis) or disease. Therefore, assays of these enzymes are very useful in diagnosis of diseases.

What is Km significance?

Description : What is Km significance? 

Last Answer : Km is independent of enzyme concentration. Km value is thus constant for an enzyme. It is the characteristic feature of a particular enzyme for a specific substrate. Km denotes the affinity of enzyme to ... the lesser the numerical value of Km, the affinity of the enzyme for the substrate is more.