Description : What is the clinical significance of transketolase enzyme?
Last Answer : The transketolase reaction is measured in RBCs as an index of the thiamine status of an individual.
Description : What is the clinical significance of C peptide?
Last Answer : Sometimes measurement of endogenous insulin may be difficult because of the presence of antibodies against insulin in the circulation. Then measurement of C-peptide is useful.
Description : What is the clinical significance of GDM?
Last Answer : Women with GDM are at increased risk for subsequent development of frank diabetes. GDM is associated with increased birth weight of child and increased incidence of neonatal mortality.
Description : What is their clinical significance?
Last Answer : Their normal levels in blood are very low, but are drastically increased during cell death (necrosis) or disease. Therefore, assays of these enzymes are very useful in diagnosis of diseases.
Description : What is the clinical significance of transami- nases?
Last Answer : Transaminases in blood are elevated in liver and heart diseases.
Description : What is its clinical significance?
Last Answer : Digoxin increases the contractility of the cardiac muscle, by inhibiting the sodium pump
Description : Pentose phosphate pathway is of significance because it generates (A) NADPH for reductive synthesis (B) Regenerates glucose 6-phosphate (C) Generates fructose 6-phosphate (D) Forms glyceraldehyde 3-phosphate
Last Answer : Answer : A
Description : Which of the following statements about the coagulation cascade is/are true? A. The intrinsic pathway of coagulation is the predominant pathway in vivo for hemostasis and coagulation. ... coagulation abnormalities. D. Deficiencies of factor XII cause severe clinical bleeding syndromes.
Last Answer : Answer: AC DISCUSSION: Although it was previously held that two somewhat distinct pathways existed for the activation of the coagulation cascade, it is now recognized that the predominant ... bleeding. This further emphasizes the secondary role that the intrinsic pathway plays in coagulation
Description : Clinical significance of competitive inhibitors -Biology
Last Answer : answer:
Description : Infectious disease transmission during blood transfusions is of clinical significance to surgeons and of major importance to patients contemplating surgery potentially associated with the need for ... transmission in blood transfusions is significantly less than the risk of hepatitis transmission
Last Answer : Answer: c, d The most common infectious diseases transmitted during blood transfusions include viral hepatitis, CMV, and HIV infection. Post-transfusion hepatitis in 90% of cases consists of ... infectious disease transmission, the risks of HIV transmission is markedly less than that of hepatitis
Description : Clinical features of hyperthyroidism include (A) Goitre, heat intolerance, weight loss and tachycardia (B) Goitre, tremors, tachycardia and cold intolerance (C) Exophthalmos, goiter, tachycardia and loss of appetite (D) Exophthalmos, goiter, tremors and obesity
Description : Clinical jaundice is present with an icteric index above (A) 4 (B) 8 (C) 10 (D) 15
Last Answer : Answer : D
Description : Clinical symptom in urea cycle disorder is (A) Mental retardation (B) Drowsiness (C) Diarrhoea (D) Oedema
Description : Clinical features of Kwashiorkor include all of the following except (A) Mental retardation (B) Muscle wasting (C) Oedema (D) Anaemia
Description : What is the clinical application of fructose estimation in semen?
Last Answer : Fructose is secreted by seminal vesicles. A block in seminal vessels is indicated by the absence of fructose in semen.
Description : Abnormal transketolase leads to what clinical condition?
Last Answer : The occurrence of Wernickís encephalopathy (seen in alcoholics and in thiamine deficiency) is due to a genetic defect in the enzyme transketolase. It occurs owing to the enzyme having low binding capacity for TPP.
Description : What is the clinical importance of lactosuria?
Last Answer : The condition is harmless. But it is important to distinguish lactosuria from glucosuria when gestational diabetes mellitus is suspected.
Description : What are the characteristic clinical features of von Gierkeís disease?
Last Answer : Fasting hypoglycemia, which does not respond to adrenaline is very characteristic.
Description : Give the clinical implications of these enzymes.
Last Answer : In infective hepatitis, ALT level is increased; in alcohol abuse, GGT level is increased; in obstructive jaundice, ALP level is increased.
Description : Give examples of clinical application of competitive inhibition.
Last Answer : Sulfonamide inhibits PABA incorporation in bacteria, and so acts as an antibacterial agent. Methotrexate inhibits folate reductase system, dicoumarol inhibits vitamin K.
Description : Which pathway is correct for catabolism of purines to form uric acid? (A) Guanylate→Adenylate→Xanthine→hypoxanthine→Uric acid (B) Guanylate→inosinate→Xanthine→hypoxanthine→Uric acid (C) Adenylate→Inosinate→Xanthine hypoxanthine→Uric acid (D) Adenylate→Inosinate→hypoxanthine Xanthine→Uric acid
Description : Cancer cells may become resistant to amethopterin by (A) Developing mechanisms to destroy amethopterin (B) Amplification of dihydrofolate reducatse gene (C) Mutation in the dihydrofolate reductase ... is no longer inhibited by amethopterin (D) Developing alternate pathway of thymidylate synthesis
Last Answer : Answer : B
Description : The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP
Description : In the pathway of de novo synthesis of purine nucleotides, all the following are allosteric enzymes except (A) PRPP glutamyl amido transferase (B) Adenylosuccinate synthetase (C) IMP dehydrogenase (D) Adenylosuccinase
Description : In the synthetic pathway of epinephrine, disulfiram (antabuse) inhibits the enzyme: (A) Tyrosine hydroxylase (B) Dopamine β-hydroxylase (C) DOPA decarboxylase (D) N-methyl transferase
Description : Substrate-linked phosphorylation occurs in (A) Glycolytic pathway(B) Citric acid cycle (C) Both (A) and (B) (D) None of these
Last Answer : Answer : C
Description : In conversion of lactic acid to glucose, three reactions of glycolytic pathway are circumvented, which of the following enzymes do not participate? (A) Pyruvate carboxylase (B) Phosphoenol pyruvate carboxy kinase (C) Pyruvate kinase (D) Glucose-6-phosphatase
Description : Which one of the following statements is not characteristic of allosteric enzymes? (A) They frequently catalyze a committed step early in a metabolic pathway (B) They are often composed of subunits (C) They follow Michaelis-Menten kinetics (D) They frequently show cooperativity for substrate binding
Description : The maximum possible chain length of fatty acids formed in the pathway of de novo synthesis is (A) 16 Carbon atoms (B) 18 Carbon atoms (C) 20 Carbon atoms (D) 24 Carbon atoms
Description : Glycerol can enter glycolytic pathway via (A) Dihydroxyacetone phosphate (B) 1, 3-Biphospoglycerate (C) 3-Phosphoglycerate (D) 2-Phosphoglycerate
Description : Glycolytic pathway is located in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Nucleus
Description : An allosteric enzyme is generally inhibited by (A) Initial substrate of the pathway (B) Substrate analogues (C) Product of the reaction catalysed by allosteric enzyme (D) Product of the pathway
Description : The rate limiting reaction in the lipogenic pathway is (A) Acetyl-CoA carboxylase step (B) Ketoacyl synthase step (C) Ketoacyl reductase step (D) Hydratase step
Description : The main source of reducing equivalents (NADPH) for lipogenesis is (A) Pentose phosphate pathway (B) Citric acid cycle (C) Glycolysis (D) Glycogenolysis
Description : The main pathway for denovo synthesis of fatty acids occur in (A) Cytosol (B) Mitochondria (C) Microsomes (D) Nucleus
Description : In the pathway leading to biosynthesis of acetoacetate from acetyl-CoA in liver, the immediate precursor of aceotacetate is (A) Acetoacetyl-CoA (B) 3-Hydroxybutyryl-CoA (C) 3-Hydroxy-3-methyl-glutaryl-CoA (D) 3-Hydroxybutyrate
Description : ω-oxidation is normally a very minor pathway and is brought by hydroxylase enzymes involving (A) Cytochrome a (B) Cytochrome b (C) Cytochrome c (D) Cytochrome p-450
Description : For conjugation with many enogenous and exogenous substances before elimination in urine, the uronic acid pathway provides (A) Active glucuronate (B) Gulonate (C) Xylulose (D) Xylitol
Description : Hemolytic anemia is caused by the deficiency of certain enzymes of the pentose phosphate pathway, the principal enzyme involved is (A) Glucose-6-phosphate dehydrogenase (B) Aldolase (C) Fructose 1, 6-bisphosphatase (D) Phosphohexose isomerase
Description : The pentose phosphate pathway protects erythrocytes against hemolysis by assisting the enzyme: (A) Superoxide dismutase (B) Catalase (C) Glutathionic peroxidase (D) Cytochrome oxidase ENZYMES 149
Description : The transketolase enzyme in the pentose phosphate pathway requires the B vitamin. (A) Pantothenic acid (B) Thiamin (C) Riboflavin (D) Nicotinic acid
Description : In pentose phosphate pathway, D-ribulose5-phosphate is converted to D-ribose-5- phosphate by the enzyme: (A) Fumarase (B) Ketoisomerase (C) G-6-PD (D) Epimerase
Description : The enzymes of the pentose phosphate pathway are found in the (A) Cytosol (B) Mitochondria (C) Nucleus (D) Endoplasmic reticulum
Description : The hydrogen acceptor used in pentose phosphate pathway is (A) NAD (B) NADP (C) FAD (D) FMN
Description : The hexose monophosphate pathway includes the enzyme: (A) Maltase dehydrogenase (B) Hexokinase (C) α-Ketoglutarate dehydrogenase (D) Glucose-6-phosphate dehydrogenase
Description : The pathway of glycogen biosynthesis involves a special nucleotide of glucose. In the reaction below, NuDP stands for NuDP Glucose + glycogenn → NuDP + glycogenn+1 (A) ADP (B) GDP (C) UDP (D) CDP
Description : In the erythrocytes, the net production of ATP molecules by the Rapport-Leubering pathway is (A) 0 (B) 2 (C) 4 (D) 8
Description : Most major metabolic pathways are considered mainly either anabolic or catabolic. Which of the following pathway is most correctly considered to be amphibolic? (A) Citric acid cycle (B) Gluconeogenesis (C) Lipolysis (D) Glycolysis
Description : All the enzymes of glycolysis pathway are found in (A) Extramitochondrial soluble fraction of the cell (B) Mitochondria (C) Nucleus (D) Endoplasmic reticulum
Description : In the glycolytic pathway, enolpyruvate is converted to ketopyruvate by (A) Pyruvate kinase (B) Phosphoenolpyruvate (C) Pyruvate dehydrogenase (D) Spontaneously