What is the clinical significance of transketolase enzyme?

What is the clinical significance of transketolase enzyme?
by

1 Answer

Answer :

The transketolase reaction is measured in RBCs as an index of the thiamine status of an individual.
by

Related questions

Abnormal transketolase leads to what clinical condition?

Description : Abnormal transketolase leads to what clinical condition?

Last Answer : The occurrence of Wernickís encephalopathy (seen in alcoholics and in thiamine deficiency) is due to a genetic defect in the enzyme transketolase. It occurs owing to the enzyme having low binding capacity for TPP.

Acute hemolytic episode after administration of antimalarial, primaquin, is due to deficiency of the enzyme: (A) 6-Phosphogluconate dehydrogenase (B) Glucose-6-phosphate dehydrogenase (C) Epimerase (D) Transketolase

Description : Acute hemolytic episode after administration of antimalarial, primaquin, is due to deficiency of the enzyme: (A) 6-Phosphogluconate dehydrogenase (B) Glucose-6-phosphate dehydrogenase (C) Epimerase (D) Transketolase

Last Answer : Answer : B

Acute hemolytic anemia in person’s sensitive to the Fava beans is due to the deficiency of the enzyme: (A) Pyruvate dehydrogenase (B) G-6-PD (C) Aconitase (D) Transketolase

Description : Acute hemolytic anemia in person’s sensitive to the Fava beans is due to the deficiency of the enzyme: (A) Pyruvate dehydrogenase (B) G-6-PD (C) Aconitase (D) Transketolase

Last Answer : Answer : B

The transketolase enzyme in the pentose phosphate pathway requires the B vitamin. (A) Pantothenic acid (B) Thiamin (C) Riboflavin (D) Nicotinic acid

Description : The transketolase enzyme in the pentose phosphate pathway requires the B vitamin. (A) Pantothenic acid (B) Thiamin (C) Riboflavin (D) Nicotinic acid

Last Answer : Answer : B

Which of the following enzyme is not involved in HMP shunt? (A) Glyceraldehyde-3-p dehydrogenase (B) Glucose-6-p-dehydrogenase (C) Transketolase (D) Phosphogluconate dehydrogenase

Description : Which of the following enzyme is not involved in HMP shunt? (A) Glyceraldehyde-3-p dehydrogenase (B) Glucose-6-p-dehydrogenase (C) Transketolase (D) Phosphogluconate dehydrogenase

Last Answer : A

What is the clinical significance of polyol pathway?

Description : What is the clinical significance of polyol pathway?

Last Answer : The elevated level of sorbitol has been implicated in the development of neuropathy, cataract and retinopathy in diabetes mellitus.

What is the clinical significance of C peptide?

Description : What is the clinical significance of C peptide?

Last Answer : Sometimes measurement of endogenous insulin may be difficult because of the presence of antibodies against insulin in the circulation. Then measurement of C-peptide is useful.

What is the clinical significance of GDM?

Description : What is the clinical significance of GDM?

Last Answer : Women with GDM are at increased risk for subsequent development of frank diabetes. GDM is associated with increased birth weight of child and increased incidence of neonatal mortality.

What is their clinical significance?

Description : What is their clinical significance?

Last Answer : Their normal levels in blood are very low, but are drastically increased during cell death (necrosis) or disease. Therefore, assays of these enzymes are very useful in diagnosis of diseases.

What is the clinical significance of transami- nases?

Description : What is the clinical significance of transami- nases?

Last Answer : Transaminases in blood are elevated in liver and heart diseases.

What is its clinical significance?

Description : What is its clinical significance?

Last Answer : Digoxin increases the contractility of the cardiac muscle, by inhibiting the sodium pump

Transketolase activity is affected in (A) Bitoin deficiency (B) Pyridoxine deficiency (C) PABA deficiency (D) Thiamine deficiency

Description : Transketolase activity is affected in (A) Bitoin deficiency (B) Pyridoxine deficiency (C) PABA deficiency (D) Thiamine deficiency

Last Answer : Answer : D

Transketolase activity is affected in (A) Biotin deficiency (B) Pyridoxine deficiency (C) PABA deficiency (D) Thiamine deficiency

Description : Transketolase activity is affected in (A) Biotin deficiency (B) Pyridoxine deficiency (C) PABA deficiency (D) Thiamine deficiency

Last Answer : B

Transketolase has the coenzyme: (A) NAD+ (B) FP (C) TPP (D) Pyridoxol phosphate

Description : Transketolase has the coenzyme: (A) NAD+ (B) FP (C) TPP (D) Pyridoxol phosphate

Last Answer : C

Transketolase activity is decreased in the deficiency what?

Description : Transketolase activity is decreased in the deficiency what?

Last Answer : Thiamine pyrophosphate (TPP).

Clinical significance of competitive inhibitors -Biology

Description : Clinical significance of competitive inhibitors -Biology

Last Answer : answer:

Infectious disease transmission during blood transfusions is of clinical significance to surgeons and of major importance to patients contemplating surgery potentially associated with the need for blood administration. Which of the following statement(s) is/are true concerning the transmission of infectious disease during blood transfusions? a. Post-transfusion hepatitis is usually due to hepatitis B b. Hepatitis and HIV transmission is greatest with the administration of pooled plasma products such as serum albumin c. The most important cause of post-transfusion disease in immunosuppressed patients is CMV infection d. The risk of HIV transmission in blood transfusions is significantly less than the risk of hepatitis transmission

Description : Infectious disease transmission during blood transfusions is of clinical significance to surgeons and of major importance to patients contemplating surgery potentially associated with the need for ... transmission in blood transfusions is significantly less than the risk of hepatitis transmission

Last Answer : Answer: c, d The most common infectious diseases transmitted during blood transfusions include viral hepatitis, CMV, and HIV infection. Post-transfusion hepatitis in 90% of cases consists of ... infectious disease transmission, the risks of HIV transmission is markedly less than that of hepatitis

Transketolase activity is affected in (A) Bitoin deficiency (B) Pyridoxine deficiency (C) PABA deficiency (D) Thiamine deficiency

Description : Transketolase activity is affected in (A) Bitoin deficiency (B) Pyridoxine deficiency (C) PABA deficiency (D) Thiamine deficiency

Last Answer : D) Thiamine deficiency

The first clinical gene therapy was given in 1990 to a 4 years old with enzyme deficiency of

Description : The first clinical gene therapy was given in 1990 to a 4 years old with enzyme deficiency of

Last Answer : The first clinical gene therapy was given in 1990 to a 4 years old with enzyme deficiency ... tyrosine oxidase C. monaine oxidase D. monamine oxidase

Clinical features of hyperthyroidism include (A) Goitre, heat intolerance, weight loss and tachycardia (B) Goitre, tremors, tachycardia and cold intolerance (C) Exophthalmos, goiter, tachycardia and loss of appetite (D) Exophthalmos, goiter, tremors and obesity

Description : Clinical features of hyperthyroidism include (A) Goitre, heat intolerance, weight loss and tachycardia (B) Goitre, tremors, tachycardia and cold intolerance (C) Exophthalmos, goiter, tachycardia and loss of appetite (D) Exophthalmos, goiter, tremors and obesity

Last Answer : Answer : A

Clinical jaundice is present with an icteric index above (A) 4 (B) 8 (C) 10 (D) 15

Description : Clinical jaundice is present with an icteric index above (A) 4 (B) 8 (C) 10 (D) 15

Last Answer : Answer : D

Clinical symptom in urea cycle disorder is (A) Mental retardation (B) Drowsiness (C) Diarrhoea (D) Oedema

Description : Clinical symptom in urea cycle disorder is (A) Mental retardation (B) Drowsiness (C) Diarrhoea (D) Oedema

Last Answer : Answer : A

Clinical features of Kwashiorkor include all of the following except (A) Mental retardation (B) Muscle wasting (C) Oedema (D) Anaemia

Description : Clinical features of Kwashiorkor include all of the following except (A) Mental retardation (B) Muscle wasting (C) Oedema (D) Anaemia

Last Answer : Answer : A

What is the clinical application of fructose estimation in semen?

Description : What is the clinical application of fructose estimation in semen?

Last Answer : Fructose is secreted by seminal vesicles. A block in seminal vessels is indicated by the absence of fructose in semen.

What is the clinical importance of lactosuria?

Description : What is the clinical importance of lactosuria?

Last Answer : The condition is harmless. But it is important to distinguish lactosuria from glucosuria when gestational diabetes mellitus is suspected.

What are the characteristic clinical features of von Gierkeís disease?

Description : What are the characteristic clinical features of von Gierkeís disease?

Last Answer : Fasting hypoglycemia, which does not respond to adrenaline is very characteristic.

Give the clinical implications of these enzymes.

Description : Give the clinical implications of these enzymes. 

Last Answer : In infective hepatitis, ALT level is increased; in alcohol abuse, GGT level is increased; in obstructive jaundice, ALP level is increased.

Give examples of clinical application of competitive inhibition.

Description : Give examples of clinical application of competitive inhibition. 

Last Answer : Sulfonamide inhibits PABA incorporation in bacteria, and so acts as an antibacterial agent. Methotrexate inhibits folate reductase system, dicoumarol inhibits vitamin K.

On which day following acute myocardial infarction the estimation of serum AST will be of greatest significance? (A) First day (B) Second day (C) Third day (D) Fourth day

Description : On which day following acute myocardial infarction the estimation of serum AST will be of greatest significance? (A) First day (B) Second day (C) Third day (D) Fourth day

Last Answer : Answer : B

Pentose phosphate pathway is of significance because it generates (A) NADPH for reductive synthesis (B) Regenerates glucose 6-phosphate (C) Generates fructose 6-phosphate (D) Forms glyceraldehyde 3-phosphate

Description : Pentose phosphate pathway is of significance because it generates (A) NADPH for reductive synthesis (B) Regenerates glucose 6-phosphate (C) Generates fructose 6-phosphate (D) Forms glyceraldehyde 3-phosphate

Last Answer : Answer : A

What is the significance of lipoprotein (a)?

Description : What is the significance of lipoprotein (a)? 

Last Answer : Lp(a) is associated with heart attacks at the age of 30 or 40 years. Indians have a higher level of Lp(a) than Europeans.

What is the significance of glycated hemoglobin?

Description : What is the significance of glycated hemoglobin?

Last Answer : The determination of glycated hemoglobin is not for diagnosis of diabetes mellitus, but for monitoring the response of treatment. It is unaffected by recent food intake or recent ... . The risk of retinopathy and renal complications are proportionately increased with elevated glycatedhemoglobin.

What is the significance of gluconeogenesis?

Description : What is the significance of gluconeogenesis?

Last Answer : Gluconeogenesis is necessary to maintain blood glucose level especially under conditions of starvation.

What is the significance of Glycolysis?

Description : What is the significance of Glycolysis?

Last Answer : It is the only pathway that is taking place in all the cells of the body. Glycolysis is the only source of energy in erythrocytes. Moreover, anaerobic glycolysis forms the major source of energy in actively contracting muscles.

What is the significance of ALT?

Description : What is the significance of ALT?

Last Answer : Very high values are seen in acute hepatitis. Rise in ALT levels may be noticed several days before clinical signs such as jaundice are manifested. Moderate increase may be seen in chronic liver diseases such as cirrhosis, and malignancy in liver.

What is the significance of AST?

Description : What is the significance of AST?

Last Answer : It is significantly elevated in myocardial infarction and moderately elevated in liver diseases.

What is the significance of zymogen activation?

Description : What is the significance of zymogen activation?

Last Answer : Gastro-intestinal enzymes are synthesised in the form of pro-enzymes, and only after secretion into the alimentary canal, they are activated. This prevents autolysis of cellular structural ... form, their activation takes place only when necessity arises. This prevents intravascular coagulation.

What is Km significance?

Description : What is Km significance? 

Last Answer : Km is independent of enzyme concentration. Km value is thus constant for an enzyme. It is the characteristic feature of a particular enzyme for a specific substrate. Km denotes the affinity of enzyme to ... the lesser the numerical value of Km, the affinity of the enzyme for the substrate is more.

What is the significance of SH groups in pro- teins?

Description : What is the significance of SH groups in pro- teins?

Last Answer : The SH group of cysteine can form a disulfide (S- S) bond with another cysteine residue. The two cysteine residues can connect two polypeptide chains by the formation of interchain disulfide bonds.

What is the biological significance of transami- nation reaction?

Description : What is the biological significance of transami- nation reaction?

Last Answer : These are important for the interconversion of amino acids. Non-essential amino acids are syn- thesized by this process

How and why do we compare drugs to standard of care during clinical trials?

Description : How and why do we compare drugs to standard of care during clinical trials?

Last Answer : I think it's useful to think separately about the % effectiveness of the new drug and the drug company's decision to produce it. The costs to finish bringing the new one drug to market might not have ... t get much use out the usual medication, or it needs a boost, ask your doctor about this kind.

How much would poor penmanship and poor spelling hinder me one becoming a clinical psychologist?

Description : How much would poor penmanship and poor spelling hinder me one becoming a clinical psychologist?

Last Answer : Most things are probably done online. A psychologist writes down notes from meetings but probably types them up on a computer after, or puts them in a file. The notes might require neat, or at least ... t know how much time or money you have but that could be a reason to consider another career.

Does anyone know the clinical word or term for this?

Description : Does anyone know the clinical word or term for this?

Last Answer : Compassion?

Should a woman on meds for clinical depression have a baby?

Description : Should a woman on meds for clinical depression have a baby?

Last Answer : God, no. I can’t tell you anything specific about anti depression meds but the general idea of what those meds are trying to do to her body plus the craziness of carrying a child is not something that is meant to be combined in nature. Those meds are bad news to begin with.

What are the advantages/disadvantages of being diagnosed with Clinical Isolated Syndrome (CIS) versus Multiple Sclerosis (MS)?

Description : What are the advantages/disadvantages of being diagnosed with Clinical Isolated Syndrome (CIS) versus Multiple Sclerosis (MS)?

Last Answer : My knowledge is very limited on this, and I am not a medical professional. I think it means your doctor is hoping you will not go on to develop MS, but had a single neurological episode of some sort. Did ... this is also considered a good sign, and may be why the doctor has called it CIS and not MS.

Has anyone used IS Clinical Active Serum? What was your experience with it?

Description : Has anyone used IS Clinical Active Serum? What was your experience with it?

Last Answer : answer:I refuse to buy 1oz of water for $128 Here are the ingredients: Water/Aqua/Eau, Glycerin, Glyceryl Polyacrylate, Butylene Glycol, SD Alcohol 30, Saccharum Officinarum (Sugar Cane) Extract, Vaccinium ... give myself an at home peel along with some others. Overall, serums are a waste of funds.

Are there any Social Workers in the Baltimore/Washington metro area preparing for the clinical exam ?

Description : Are there any Social Workers in the Baltimore/Washington metro area preparing for the clinical exam ?

Last Answer : My fiance would be happy to study with you.

Are there any deodorants stronger than "clinical strength"?

Description : Are there any deodorants stronger than "clinical strength"?

Last Answer : Weight lose can change your bodies odor chemistry, as for a strong deodorants I would suggest asking your doctor.

Do obsessive thoughts or actions follow with clinical depression or bi-polar disorder?

Description : Do obsessive thoughts or actions follow with clinical depression or bi-polar disorder?

Last Answer : obssessing and compulsing are actually two different things. obssesing is being unable to stop thinking about thinking about whatever. complusing is that actual disease part - you do something compulsively over and ... your ability to funciton in day-to-day life, that's the disease known as OCD.

Does anyone know what the rate of success must be for an FDA approved clinical trial.

Description : Does anyone know what the rate of success must be for an FDA approved clinical trial.

Last Answer : Sadly, I do not. Check this out: http://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinicalTrials/default.htm Might be a link or two there that can help somewhat. I would have to ... , try contacting a local university and getting a pharmacology/genetics/biochemistry grad student on the phone.