Intracellular digestion is that in which the breaking down of macromolecules takes place within the cell. Extracellular digestion is that in which macromolecules are broken down in places outside the cell (in the extracellular space, in the surrounds, in the lumen of digestive tubes, etc.) The advent of extracellular digestion in evolution allowed organisms to benefit from a greater variety of food. The breaking down of larger molecules into smaller ones outside the cell permitted the use of other foods than those that, due the size of their molecules, could not be interiorized by diffusion, phagocytosis or pinocytosis.