Description : Adenylate cyclase is activated by (A) GDP-bearing α-Subunit of G-protein (B) GTP-bearing α-Subunit of G-protein (C) GDP-bearing γ-Subunit of G-protein (D) GTP-bearing γ-Subunit of G-protein
Last Answer : Answer : B
Description : Adenylate cyclase is activated by (A) Insulin (B) Glucagon (C) Prostaglandin E1 (D) Ca2+ ions
Description : Cyclic AMP is formed from ATP by the enzyme adenylate cyclase which is activated by the hormone: (A) Insulin (B) Epinephrine (C) Testosterone (D) Progesterone
Last Answer : B
Description : Binding of insulin to its receptor activates (A) Adenylate cyclase (B) Guanylate cyclase (C) Phospholipase C (D) Tyrosine kinase
Last Answer : Answer : D
Description : Which of the following statement(s) is/are true concerning cell membrane receptors? a. The largest family of cell surface receptors are the G-protein-linked receptors b. Activities of the ... through the use adenylate cyclase d. Tyrosine kinase receptors are considered G-protein-linked receptors
Last Answer : Answer: a, c All water-soluble regulatory molecules bind to the cell surface receptor proteins. Binding of the appropriate ligand evokes an intracellular signal which usually regulates ... are adenylate cyclase, which converts ATP to cAMP, and the polyphosphoinositide-specific phospholipase C
Description : Select the hypolipidemic drug that enhances lipoprotein synthesis, fatty acid oxidation and LDLreceptor expression in liver through paroxisome proliferator-activated receptor α: A. Lovastatin B. Atorvastatin C. Bezafibrate D. Nicotinic acid
Last Answer : C. Bezafibrate
Description : cAMD is destroyed by (A) Adenylate cyclase (B) Phosphodiesterase (C) Synthetase phosphatase (D) Synthetase kinase
Description : Whcih of the following hormone does not activate adenylate cyclase? (A) Epinephrine (B) Glucagon (C) Parathyroid hormone (D) Insulin
Description : Binding of thyroxine to its receptors (A) Activates Adenylate cyclase (B) Activates guanylate cyclase (C) Activates a stimulatory G-protein (D) Increases transcription
Description : Rod cells possess a trans-membrane protein which is (A) Adenylate cyclase (B) Transducin (C) Rhodopsin (D) B as well as C
Last Answer : Answer : C
Description : The best understood intracellular messenger is cyclic AMP (cAMP). Which of the following statement(s) concerning this intracellular messenger is/are correct? a. Intracellular cyclic AMP is constantly ... of adenylate cyclase d. cAMP is the only cyclic nucleotide active as an intracellular messenger
Last Answer : Answer: a, b The prototypic intracellular messenger is cAMP. To function as a mediator, the concentration of cAMP must change rapidly. In resting cells, cAMP is continuously being degraded by ... produce cGMP. Intracellular calcium ions also serve as second messengers in a large number of cells
Description : Human urine is usually acidic because (a) potassium and sodium exchange generates acidity (b) hydrogen ions are actively secreted into the filtrate (c) the sodium transporter exchanges one hydrogen ion for each sodium ion, in peritubular capillaries (d) excreted plasma proteins are acidic.
Last Answer : (b) hydrogen ions are actively secreted into the filtrate
Description : Drugs that block the a receptor on effector cells at adrenergic nerve endings (a) Antagonize the effects of isoproterenol on the heart rate (b) Antagonize some of the effects of epinephrine on ... the effects of epinephrine on adenylyl cyclase (d) Cause mydriasis (e) Decreases blood glucose levels
Last Answer : Ans: B
Description : G-proteins: a. are activated by the binding of an extracellular ligand to a membrane receptor b. can be mutated in tumour cells c. mediate the action of glucocorticoid hormone d. they are inactivated by cholera toxins
Last Answer : are activated by the binding of an extracellular ligand to a membrane receptor
Description : Choose the correct statement(s) about pioglitazone: A. It acts as an agonist on nuclear paroxisome proliferator receptor γ B. It enhances transcription of insulin responsive genes C. It lowers blood sugar in type 2 diabetes mellitus without causing hyperinsulinemia D. All of the above
Last Answer : D. All of the above
Description : The sugar absorbed by fac i l itated diffusion and requiring Na independent transporter is (A) Glucose (B) Fructose (C) Galactose (D) Ribose
Description : ADP ribosylation is the mode of action of (A) Cholera toxin (B) Acetyl choline (C) Muscerinic receptors (D) Cyclic AMP
Last Answer : Answer : A
Description : Insulin increases the permeability of glucose across the plasma membrane of muscle cells by (A) Acting on adenylate cycle (B) By loosening the integrity of the membrane (C) Through Ca2 ... membrane cruting the hexose carries of intracellular organelles and making them fuse with the plasma membrane
Description : Actions of 5-HT2 receptor activation are primarily mediated by: A. Increased membrane permeability to Na+ ions B. Increased formation of cAMP C. Activation of guanylyl cyclase D. Generation of inositol trisphosphate and diacyl glycerols
Last Answer : D. Generation of inositol trisphosphate and diacyl glycerols
Description : The dopamine D2 receptor has the following feature: A. It is excitatory in nature B. It is negatively coupled to adenyl cyclase C. It is selectively blocked by bromocriptine D. It is not blocked by metoclopramide
Last Answer : B. It is negatively coupled to adenyl cyclase
Description : The receptor transduction mechanism with the fastest time-course of response effectuation is: A. Adenylyl cyclase-cyclic AMP pathway B. Phospholipase C-IP3: DAG pathway C. Intrinsic ion channel operation D. Protein synthesis modulation
Last Answer : C. Intrinsic ion channel operation
Description : What is true about Bt toxin? (a) Bt protein exists as active toxin in the Bacillus. (b) The activated toxin enters the ovaries of the pest to sterilise it and thus prevent its multiplication. ... Bacillus has antitoxins. (d) The inactive protoxin gets converted into active form in the insect gut.
Last Answer : (d) The inactive protoxin gets converted into active form in the insect gut.
Description : Bacillus thuringiensis forms protein crystals which contain insecticidal protein. This protein (a) binds with epithelial cells of midgut of the insect pest ultimately killing it (b) is coded by several ... pest (d) does not kill the carrier bacterium which is itself resistant to this toxin.
Last Answer : (a) binds with epithelial cells of midgut of the insect pest ultimately killing it
Description : a2–adrenergic receptors are associated with following except (a) Increase in phospholipase C activity (b) Increase in potassium channel conductance (c) Decrease in calcium channel conductance (d) Increase in adenylyl cyclase activity
Last Answer : Ans: D
Description : Which one of the following is characteristic of captopril and enalapril ? (a) Competitively blocks angiotensim II at its receptor (b) Decreases angiotensin II concentration in the blood (c) Decreases ... and decreases potassium in the blood (e) Decreases sodium and increases potassium in the urine
Description : Potassium therapy tends to counteract the cardiac toxicity of digitalis by: A. Reducing the affinity of sarcolemal Na+ K+ATPase for digitalis B. Suppressing ectopic automaticity enhanced by digitalis C. Promoting A-V conduction D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : There are two properties of the cell necessary to maintain nonequilibrium cellular composition; the first is selectivity and the second is energy conversion. Which of the following statement(s ... transported via secondary active transport include hydrogen ions, calcium, amino acids and glucose
Last Answer : Answer: c, d The selectivity of the plasma membrane, although impressive, cannot account for the nonequilibrium composition of living cells. A cell can be maintained in a nonequilibrium state only by ... to drive the transport of a second species such as protons, calcium, amino acids, or glucose
Description : Antivenom injection contains preformed antibodies while polio drops that are administered into the body contain (a) gamma globulin (b) attenuated pathogens (c) activated pathogens (d) harvested antibodies
Last Answer : (b) attenuated pathogens
Description : True statements about aldosterone include: a. it increases the amount of Na+-K+ ATPase in the target cells b. it reduces the sodium content of the sweat c. it increases the acidity of urine d. all above
Last Answer : all above
Description : The following are true about G proteins: a. they are first messengers b. when activated, the alpha subunit exchange GDP for GTP c. they are transmembrane signal receptor molecules d. vibrio cholerae secrets an exotoxin which makes G-proteins resistant to inactivation
Last Answer : when activated, the alpha subunit exchange GDP for GTP
Description : Which of the following statements are true of a patient with hyperglycemia and hyponatremia? A. The sodium concentration must be corrected by 5 mEq. per 100 mg. per 100 ml. elevation in blood ... . E. Early in treatment adequate urine output is a reliable measure of adequate volume resuscitation.
Last Answer : Answer: D DISCUSSION: Each 100-mg. per 100 ml. elevation in blood glucose causes a fall in serum sodium concentration of approximately 2 mEq. per liter. Excess serum glucose ... correction of the patient's associated acidosis produce movement of potassium ions into the intracellular compartment
Description : Which of the following complications of TPN are appropriately managed with the listed treatment? a. Air embolism-place patient in reverse Trendelenburg and the left lateral decubitus position ... dioxide retention-decrease glucose calories and replace with fat d. Line sepsis-intravenous antibiotics
Last Answer : Answer: b, c A number of complications of TPN can occur which can be divided into three types: mechanical, metabolic, and infectious
Description : The following are found in higher concentration in the tear than in the serum: a. sodium b. potassium c. Ig G d. glucose
Last Answer : potassium
Description : The following have a lower concentration in the cerebrospinal fluid (CSF) than plasma: a. glucose b. sodium c. potassium d. magnesium
Last Answer : magnesium
Description : The ______ are programs that run on DNS clients and DNS servers and that create queries to extract information from name servers. A. transporter B. distributers C. Resolvers D. both a and b
Last Answer : C. Resolvers
Description : Which of the following consolidates shipments from several organisations into efficient lot sizes? A)Freight forwarder B)Forwarding agency C)Transporter D)Special transportation company E)Intermodal shipping company
Last Answer : A)Freight forwarder
Description : In biosynthesis of cholesterol triparanol inhibits the activity of the enzyme: (A) ∆24 Reductase (B) Oxidosqualene-lanosterol cyclase (C) Isomerase (D) Squalene epoxidase ENZYMES 155
Description : Calcium is required for the activation of the enzyme: (A) Isocitrate dehydrogenase (B) Fumarase (C) Succinate thiokinase (D) ATPase
Description : Na+/K+-ATPase along with ATP requires (A) Ca (B) Mn (C) Mg (D) Cl
Description : eIF-4 A possesses (A) ATPase activity (B) GTPase activity (C) Helicase activity (D) None of these
Description : All the following statements about Wilson’s disease are correct except (A) It is a genetic disease (B) The defect involves copper-dependent P-type ATPase (C) Copper is deposited in liver, basal ganglia and around cornea (D) Plasma copper level is increased in it
Description : Calcitriol facilitates calcium absorption by increasing the synthesis of the following in intestinal mucosa: (A) Calcium Binding Protein (B) Alkaline Phosphatase (C) Calcium-dependent ATPase (D) All of these
Description : With the exception of glycine all amino acids found in protein are (A) Isocitrate dehydrogenase (B) Fumarase (C) Succinate thiokinase (D) ATPase
Description : All of the following statements about the enzymic complex that carries out the synthesis of ATP during oxidative phosphorylation are correct except (A) It is located on the matrix side of the inner ... inhibited by oligomycin (C) It can exhibit ATPase activity (D) It can bind molecular O2
Last Answer : D
Description : Following potassium sparing diuretic is a mineralocorticoid receptor antagonist (a) Amiloride (b) Triamterene (c) Spironolactone (d) All of the above
Last Answer : Ans: C
Description : Mitochondrial protein synthesis is inhibited by (A) Cycloheximide (B) Chloramphenicol (C) Diptheria toxin (D) None of these
Description : Diphtheria toxin inhibits (A) Prokaryotic EF-1 (B) Prokaryotic EF-2 (C) Eukaryotic EF-1 (D) Eukaryotic EF-2
Description : All of the following statements about hypoglycin are true except (A) It is a plant toxin (B) It causes hypoglycaemia (C) It inhibits oxidation of short chain fatty acids (D) It inhibits oxidation of long chain fatty acids
Description : A lipid bilayer is permeable to (A) Urea (B) Fructose (C) Glucose (D) Potassium
Last Answer : A
Description : A 53-year-old man presented with hypertension of 150/110 mmHg. He is generally asymptomatic and has no previous medical history of note. He is a smoker of 5 cigarettes daily and drinks ... Adrenocortical adenoma 2) Bartter's syndrome 3) Liddle's syndrome 4) Liquorice ingestion 5) Pheochromocytoma
Last Answer : Answers-1 This patient is most likely to have Conn's syndrome as reflected by the hypokalaemic hypertension. Liquorice ingestion or Liddle's syndrome are again possible causes of ... hypertension (often diastolic hypertension), muscular weakness, paresthesias, headache, polyuria, and polydipsia."