Choose the correct statement(s) about pioglitazone: A. It acts as an agonist on nuclear paroxisome proliferator receptor γ B. It enhances transcription of insulin responsive genes C. It lowers blood sugar in type 2 diabetes mellitus without causing hyperinsulinemia D. All of the above

Choose the correct statement(s) about pioglitazone:
A. It acts as an agonist on nuclear paroxisome
proliferator receptor γ
B. It enhances transcription of insulin responsive genes
C. It lowers blood sugar in type 2 diabetes
mellitus without causing hyperinsulinemia
D. All of the above
by

1 Answer

Answer :

D. All of the above
by

Related questions

Select the hypolipidemic drug that enhances lipoprotein synthesis, fatty acid oxidation and LDLreceptor expression in liver through paroxisome proliferator-activated receptor α: A. Lovastatin B. Atorvastatin C. Bezafibrate D. Nicotinic acid

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Last Answer : C. Bezafibrate

Choose the correct statement about nateglinide: A. It is a long acting oral hypoglycaemic drug B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus C. It lowers blood glucose in both type 1 and type 2 diabetes mellitus D. It acts by opening K+ channels in myocytes and adipocytes

Description : Choose the correct statement about nateglinide: A. It is a long acting oral hypoglycaemic drug B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus C. It lowers ... 1 and type 2 diabetes mellitus D. It acts by opening K+ channels in myocytes and adipocytes

Last Answer : B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus

Choose the correct statement(s) about actions of insulin: A. It favours translocation of glucose transporters from intracellular site to the plasma membrane B. It enhances transcription of lipoprotein lipase in vascular endothelium C. It increases production of the enzyme glucokinase D. All of the above

Description : Choose the correct statement(s) about actions of insulin: A. It favours translocation of glucose transporters from intracellular site to the plasma membrane B. It enhances transcription of lipoprotein ... vascular endothelium C. It increases production of the enzyme glucokinase D. All of the above

Last Answer : D. All of the above

The major limitation of the thiazolidinediones in the treatment of type 2 diabetes mellitus is: A. Frequent hypoglycaemic episodes B. Hyperinsulinemia C. Lactic acidosis D. Low hypoglycaemic efficacy in moderate to severe cases

Description : The major limitation of the thiazolidinediones in the treatment of type 2 diabetes mellitus is: A. Frequent hypoglycaemic episodes B. Hyperinsulinemia C. Lactic acidosis D. Low hypoglycaemic efficacy in moderate to severe cases

Last Answer : D. Low hypoglycaemic efficacy in moderate to severe cases

The following feature disfavours use of oral hypoglycaemics in diabetes mellitus: A. Age at onset of disease over 40 years B. Insulin requirement more than 40 U/day C. Fasting blood sugar level between 100–200 mg/dl D. Associated obesity

Description : The following feature disfavours use of oral hypoglycaemics in diabetes mellitus: A. Age at onset of disease over 40 years B. Insulin requirement more than 40 U/day C. Fasting blood sugar level between 100–200 mg/dl D. Associated obesity

Last Answer : B. Insulin requirement more than 40 U/day

Which of the following is not a sulfonylurea but acts by analogous mechanism to bring about quick and brief insulin release that is useful for normalizing meal time glycaemic excursions in type 2 diabetes mellitus: A. Glimepiride B. Miglitol C. Repaglinide D. Rosiglitazone

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Last Answer : C. Repaglinide

Choose the correct statement about lovastatin: A. It markedly lowers plasma triglyceride with little effect on cholesterol level B. It is used as an adjuvant to gemfibrozil for type III hyperlipoproteinemia C. It is not effective in diabetes associated hypercholesterolemia D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

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Last Answer : D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

Choose the correct statement about lamotrigine: A. It is a dopaminergic agonist used in parkinsonism B. It acts by blocking NMDA-type of glutamate receptors C. It is a broad spectrum antiepileptic drug D. It suppresses tonic-clonic seizures, but worsens absence seizures

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Last Answer : C. It is a broad spectrum antiepileptic drug

he following is true of desmopressin except: A. It is nonselective V1 and V2 receptor agonist B. It is more potent and longer acting than arginine vasopressin (AVP) C. It is preferred over AVP for treatment of diabetes insipidus D. It can be administered orally

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Last Answer : A. It is nonselective V1 and V2 receptor agonist

The following statement is correct about buspirone: A. It interacts with benzodiazepine receptor as an inverse agonist B. It is a rapidly acting anxiolytic, good for panic states C. It produces physical dependence and suppresses barbiturate withdrawal syndrome D. It has anxiolytic but no anticonvulsant or muscle relaxant propert

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Last Answer : D. It has anxiolytic but no anticonvulsant or muscle relaxant property

The present status of oral hypoglycaemics in diabetes mellitus is: A. They are the first choice drug in all cases B. They should be prescribed only if the patient refuses insulin injections C. They are used only in type I diabetes mellitus D. They are used first in most uncomplicated mild to moderate type 2 diabetics

Description : The present status of oral hypoglycaemics in diabetes mellitus is: A. They are the first choice drug in all cases B. They should be prescribed only if the patient refuses insulin injections C. ... I diabetes mellitus D. They are used first in most uncomplicated mild to moderate type 2 diabetics

Last Answer : D. They are used first in most uncomplicated mild to moderate type 2 diabetics

The thiazolidinediones are mainly used as: A. Sole drug in type 1 diabetes mellitus B. Sole drug in type 2 diabetes mellitus C. Addon drug to a sulfonylurea and/or a biguanide in type 2 diabetes mellitus D. Addon drug to insulin in type 1 diabetes mellitus (p. 250) 18.33 1 8 . 3 3 C 18.34 1 8 . 3 4 B 18.35 1 8 . 3 5 D 18.36 1 8 . 3 6 C

Description : The thiazolidinediones are mainly used as: A. Sole drug in type 1 diabetes mellitus B. Sole drug in type 2 diabetes mellitus C. Addon drug to a sulfonylurea and/or a biguanide in type 2 diabetes mellitus D. Addon drug to insulin in type 1 ... 18.34 1 8 . 3 4 B 18.35 1 8 . 3 5 D 18.36 1 8 . 3 6 C

Last Answer : C. Addon drug to a sulfonylurea and/or a biguanide in type 2 diabetes mellitus

Insulin therapy is required for the following category/ categories of type 2 diabetes mellitus patients: A. Patients with ketoacidosis B. Patients undergoing surgery C. Pregnant diabetic D. All of the above

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Last Answer : D. All of the above

Which of the following is not a specific indication for the more expensive monocomponent/human insulins: A. Insulin resistance B. Pregnant diabetic C. Sulfonylurea maintained diabetic posted for surgery D. Type 1 diabetes mellitus

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Last Answer : D. Type 1 diabetes mellitus

Insulin therapy is required for the following category/ categories of type 2 diabetes mellitus patients: A. Patients with ketoacidosis B. Patients undergoing surgery C. Pregnant diabetic D. All of the above

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Last Answer : D. All of the above

In a patient of diabetes mellitus maintained on insulin therapy, administration of the following drug can vitiate glycaemia control: A. Prednisolone B. Prazosin C. Paracetamol D. Phenytoin

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Which of the following statements is NOT true about diabetes mellitus? A) Type II diabetes is much more common than type I. B) Insulin injections are required in both type I and type II diabetes. C) Type I diabetes occurs as a result of destruction of the insulin-producing cells. D) One method of treating type II diabetes is exercise and a low-fat, low-sugar diet. E) Symptoms of diabetes include excessive thirst, frequent urination, and glucose in the urine.

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Which of the following peptides is a selective vasopressin V2 receptor agonist: A. Arginine vasopressin B. Desmopressin C. Lypessin D. Terlipressin

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Losartan is a: A. Selective AT1 receptor antagonist B. Selective AT2 receptor antagonist C. Nonselective AT1 + AT2 receptor antagonist D. AT1 receptor partial agonist

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Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects

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Cisapride enhances gastrointestinal motility by: A. Activating serotonin 5-HT4 receptor B. Activating muscarinic M3 receptor C. Blocking dopamine D2 receptor D. All of the above

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Last Answer : D. All of the above

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In the insulin receptor, tyrosine kinase domain is present in (A) α-Subunits (B) β-Subunits (C) γ-Subunits (D) δ-Subunits

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Insulin binding sites are present on the (A) α-subunits of insulin receptor (B) β-subunits of insulin receptor (C) γ-subunits of insulin receptor (D) α-and β−subunits of insulin receptor

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Which of the following is activated by Cholera toxin? 1) Adenylate cyclase 2) Guanlyate cyclase 3) Peroxisome proliferator receptor (PPAR) gamma 4) Sodium/potassium ATPase 5) The glucose-sodium transporter

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Which of the following clinical characteristics is associated with Type 2 diabetes (previously referred to as non-insulin-dependent diabetes mellitus [NIDDM])? a) Can control blood glucose through diet and exercise Oral hypoglycemic agents may improve blood glucose levels if dietary modification and exercise are unsuccessful.

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he following anthelmintic acts as a cholinergic agonist in the nematodes and causes spastic paralysis of the worms: A. Piperazine B. Pyrantel pamoate C. Mebendazole D. Thiabendazole

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Gabapentin acts: A. As GABAA agonist B. As precursor of GABA C. By enhancing GABA release D. By GABA independent mechanism

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The following is a skeletal muscle relaxant that acts as a central α2 adrenergic agonist: A. Tizanidine B. Brimonidine C. Chlormezanone D. Quinine

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Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl noradrenaline which acts as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors

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Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone

Glycocylated haemoglobin: a. is absent in the plasma of people without diabetes mellitus b. results from the combination of a HbA and a sugar c. when measured as HbA1c in plasma gives a more accurate retrospective estimates of blood sugar levels than other glycosylated products d. all above

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A man suffering from diabetes mellitus drinks water more frequently as he has to eliminate from the blood extra (1) glucose (2) insulin (4) glucagon (4) salt

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he following antidiabetic drug inhibits intestinal brush border α-glucosidase enzymes: A. Acarbose B. Pioglitazone C. Metformin D. Guargum

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Choose the correct statement about ondansetron: A. It is a dopamine D2 receptor antagonist B. It suppresses postoperative nausea and vomiting C. It is the most effective antiemetic for motion sickness D. It is not effective by oral route

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Match the following hormones with their respective disease. (A) Insulin (i) Addison’s disease (B) Thyroxin (ii) Diabetes insipidus (C) Corticoids (iii)Acromegaly (D) Growth hormone (iv) Goitre (v) Diabetes mellitus Select the correct option. (A) (B) (C) (D) (a) (ii) (iv) (i) (iii) (b) (v) (i) (ii) (iii) (c) (ii) (iv) (iii) (i) (d) (v) (iv) (i) (iii)

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Choose the correct statement about trimetazidine: A. It is a novel calcium channel blocker B. It improves tissue perfusion by modifying rheological property of blood C. It is an antianginal drug which acts by nonhaemodynamic mechanisms D. Both 'A' and 'B' are correct

Description : Choose the correct statement about trimetazidine: A. It is a novel calcium channel blocker B. It improves tissue perfusion by modifying rheological property of blood C. It is an antianginal drug which acts by nonhaemodynamic mechanisms D. Both 'A' and 'B' are correct

Last Answer : C. It is an antianginal drug which acts by nonhaemodynamic mechanisms

Name a peptide hormone which acts mainly on hepatocytes, adipocytes and enhances cellular glucose uptake and utilisation. (a) Insulin (b) Glucagon (c) Secretin (d) Gastrin

Description : Name a peptide hormone which acts mainly on hepatocytes, adipocytes and enhances cellular glucose uptake and utilisation. (a) Insulin (b) Glucagon (c) Secretin (d) Gastrin

Last Answer : (a) Insulin

In diabetic patients, round the clock tight control of hyperglycaemia achieved by multiple daily insulin injections or insulin pumps: A. Prevents macrovascular disease more effectively B. Is recommended in all type 2 diabetes patients C. Is associated with higher incidence of hypoglycaemic reactions D. Both A and C are correct

Description : In diabetic patients, round the clock tight control of hyperglycaemia achieved by multiple daily insulin injections or insulin pumps: A. Prevents macrovascular disease more effectively B. Is recommended ... Is associated with higher incidence of hypoglycaemic reactions D. Both A and C are correct

Last Answer : D. Both A and C are correct

Which of the following clinical characteristics is associated with Type 1 diabetes (previously referred to as insulin-dependent diabetes mellitus [IDDM])? a) Presence of islet cell antibodies Individuals with Type 1 diabetes often have islet cell antibodies.

Description : Which of the following clinical characteristics is associated with Type 1 diabetes (previously referred to as insulin-dependent diabetes mellitus [IDDM])? a) Presence of islet cell antibodies ... Requirement for oral hypoglycemic agents Individuals with Type 1 diabetes need insulin to preserve life.

Last Answer : a) Presence of islet cell antibodies Individuals with Type 1 diabetes often have islet cell antibodies.

Which of the following is not likely to be the cause of failure of antimicrobial therapy of an acute infection: A. Improper selection of drug and dose B. Acquisition of resistance during treatment C. Failure to drain the pus D. Uncontrolled diabetes mellitus

Description : Which of the following is not likely to be the cause of failure of antimicrobial therapy of an acute infection: A. Improper selection of drug and dose B. Acquisition of resistance during treatment C. Failure to drain the pus D. Uncontrolled diabetes mellitus

Last Answer : B. Acquisition of resistance during treatment

Prolonged lithium therapy can cause: A. Diabetes mellitus B. Goiter C. Parkinsonism D. Gout

Description : Prolonged lithium therapy can cause: A. Diabetes mellitus B. Goiter C. Parkinsonism D. Gout

Last Answer : B. Goiter

The β3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Description : The β3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Last Answer : A. Is not blocked by the conventional doses of propranolol

The β 3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Description : The β 3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Last Answer : A. Is not blocked by the conventional doses of propranolol

The insulin receptor is a: A. Ion channel regulating receptor B. Tyrosine protein kinase receptor C. G-protein coupled receptor D. None of the above

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Last Answer : B. Tyrosine protein kinase receptor

Which of the following is a G protein coupled receptor: A. Muscarinic cholinergic receptor B. Nicotinic cholinergic receptor C. Glucocorticoid receptor D. Insulin receptor

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Choose the correct statement about paracetamol: A. It increases uric acid excretion B. It is the most common drug implicated in causing analgesic nephropathy C. In equianalgesic doses it is safer than aspirin D. It stimulates cellular metabolism

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