Phenytoin: 1) is a benzalkonium Derivative 2) is clinically effective serum level is in the range on 2-10 micrograms/ml. 3) A steady state blood level is achieved by 2-5 days 4) Can be used in management of alchohol withdrawl syndrome 5) Is the drug of choice in absence seizures.

Phenytoin: 1) is a benzalkonium Derivative 2) is clinically effective serum level is in the range on 2-10 micrograms/ml. 3) A steady state blood level is achieved by 2-5 days 4) Can be used in management of alchohol withdrawl syndrome 5) Is the drug of choice in absence seizures.
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Answers-4 Phenytoin is an imidazolidine derivative.It relates to barbiturates in chemical structure. Clinically effective seum level is in the range on 10-20 micrograms/ml. A steady state blood level is achieved by 7-10 days.
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he antiepileptic drug which suppresses maximal electroshock as well as kindled seizures, raises pentylenetetrazol threshold and is effective in both generalized tonic-clonic as well as absence seizures is: A. Phenytoin B. Carbamazepine C. Sodium valproate D. Ethosuximide

Description : he antiepileptic drug which suppresses maximal electroshock as well as kindled seizures, raises pentylenetetrazol threshold and is effective in both generalized tonic-clonic as well as absence seizures is: A. Phenytoin B. Carbamazepine C. Sodium valproate D. Ethosuximide

Last Answer : C. Sodium valproate

Which of the following is the most suitable drug for a 6-year-old girl suffering from absence seizures with occasional generalized tonic-clonic seizures: A. Ethosuccimide B. Sodium valproate C. Carbamazepine D. Phenytoin

Description : Which of the following is the most suitable drug for a 6-year-old girl suffering from absence seizures with occasional generalized tonic-clonic seizures: A. Ethosuccimide B. Sodium valproate C. Carbamazepine D. Phenytoin

Last Answer : B. Sodium valproate

The serum estradiol level in women during 21–30 days of menstrual cycle is (A) 10-20 pg/ml (B) 22-66 pg/ml (C) 73-149 pg/ml (D) 1000 pg/ml

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Last Answer : Answer : C

The serum estradiol level in women during 1–10 days of menstrual cycle is (A) 0–10 pg/ml (B) 12–20 pg/ml (C) 24–68 pg/ml (D) 80–100 pg/ml

Description : The serum estradiol level in women during 1–10 days of menstrual cycle is (A) 0–10 pg/ml (B) 12–20 pg/ml (C) 24–68 pg/ml (D) 80–100 pg/ml

Last Answer : Answer : C

The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

Description : The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

Last Answer : A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened

The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

Description : The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

Last Answer : A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened

Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy

Description : Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy

Last Answer : Answer : A

The serum estradiol level in women during 11–20 days of menstrual cycle is (A) 5–30 pg/ml (B) 50–300 pg/ml (C) 500–900 pg/ml (D) 1000 pg/ml

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Last Answer : Answer : B

All of the following statements regarding pentamidine isethionate are true except (a) it is indicated for treatment or prophylaxis of infection due to Pneumocystis carinii (b) it may be administered intramuscularly, intravenously or by inhalation (c) it has no clinically significant effect on serum glucose (d) it is effective in the treatment of leishmaniasis

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Last Answer : Ans: C

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Choose the correct statement about lamotrigine: A. It is a dopaminergic agonist used in parkinsonism B. It acts by blocking NMDA-type of glutamate receptors C. It is a broad spectrum antiepileptic drug D. It suppresses tonic-clonic seizures, but worsens absence seizures

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Normal serum glucagons level in fasting state varies between (A) 0-–10 pg/ml (B) 20–100 pg/ml (C) 200–300 pg/ml (D) 400–500 pg/ml

Description : Normal serum glucagons level in fasting state varies between (A) 0-–10 pg/ml (B) 20–100 pg/ml (C) 200–300 pg/ml (D) 400–500 pg/ml

Last Answer : Answer : B

The normal range of direct reacting (conjugated) serum bilirubin is (A) 0–0.1 mg/100 ml (B) 0.1–0.4 mg/100 ml (C) 0.4–06 mg/100 ml (D) 0.5–1 mg/100 ml

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Last Answer : Answer : B

The normal range of total serum bilirubin is (A) 0.2–1.2 mg/100 ml (B) 1.5–1.8 mg/100 ml (C) 2.0–4.0 mg/100 ml (D) Above 7.0 mg/100 ml

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Last Answer : Answer : A

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Last Answer : Correct Answer: 1) 1, 2 and 4

The following is true in the treatment of epilepsy except: A. The choice of drug depends on the cause of epilepsy and not on the seizure type B. Treatment should be instituted as early as possible C. Treatment is generally started with a single drug and the other drug is added or substituted according to response D. Withdrawal of drug can be attempted if no seizures have occurred for 3-5 years

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Description : The normal range of indirect (unconjugated) bilirubin in serum is (A) 0–0.1 mg/100 ml (B) 0.1–0.2 mg/100 ml (C) 0.2–0.7 mg/100 ml (D) 0.8–1.0 mg/100 ml

Last Answer : Answer : C

The serum estradiol level in men is (A) 0–5 pg/ml (B) 5–10 pg/ml (C) 24–68 pg/ml (D) 40–60 pg/ml

Description : The serum estradiol level in men is (A) 0–5 pg/ml (B) 5–10 pg/ml (C) 24–68 pg/ml (D) 40–60 pg/ml

Last Answer : Answer : C

Normal serum level of selenium is (A) 5 µg /100 ml (B) 8 µg /100 ml (C) 10 µg /100 ml (D) 13 µg /100 ml

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Last Answer : Answer : D

In the individuals who are given liberal quantities of vitamin C, the serum ascorbic acid level is (A) 1–1.4 µg/100 ml (B) 2–4 µg/100 ml (C) 1–10 µg/100 ml (D) 10–20 µg/100 ml

Description : In the individuals who are given liberal quantities of vitamin C, the serum ascorbic acid level is (A) 1–1.4 µg/100 ml (B) 2–4 µg/100 ml (C) 1–10 µg/100 ml (D) 10–20 µg/100 ml

Last Answer : Answer : A

Which of the following has a known association with phenylketonuria? 1) Presentation in the second year of life with absence seizures. 2) The association of red hair and brown eyes. 3) Normal development. 4) Musty odour. 5) Response of some patients to piridoxine.

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The highest serum drug concentration following a single dose or at a steady state within a dosing interval is called ………. A. Lead B. Peak C. Poison D. Mechanisms

Description : The highest serum drug concentration following a single dose or at a steady state within a dosing interval is called ………. A. Lead B. Peak C. Poison D. Mechanisms

Last Answer : B. Peak 

Serum progesterone level during luteal phase is (A) 0.2–203 ng/ml (B) 3.0–5.0 ng/ml (C) 6.0–30 ng/ml (D) 750 ng/ml

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Last Answer : Answer : C

The serum progesterone level in follicular phase is about (A) 0.2–1.5 ng/100 ml (B) 2.0–2.5 ng/100 ml (C) 3.5–4.5 ng/100 ml (D) 5.0–6.5 ng/100 ml

Description : The serum progesterone level in follicular phase is about (A) 0.2–1.5 ng/100 ml (B) 2.0–2.5 ng/100 ml (C) 3.5–4.5 ng/100 ml (D) 5.0–6.5 ng/100 ml

Last Answer : Answer : A

The normal serum level of thyroxine (T4) is (A) 2.0–4.0 µg/100 ml (B) 5.5–13.5 µg/100 ml (C) 14.0–20.3 µg/100 ml (D) 20.0–25.0 µg/100 ml

Description : The normal serum level of thyroxine (T4) is (A) 2.0–4.0 µg/100 ml (B) 5.5–13.5 µg/100 ml (C) 14.0–20.3 µg/100 ml (D) 20.0–25.0 µg/100 ml

Last Answer : Answer : B

The normal serum level of triiodothyronine (T3) is (A) 0.2–0.5 ng/ml (B) 0.7–2.0 ng/ml (C) 2.0–4.0 ng/ml (D) 5.0–8.0 ng/ml HORMONE METABOLISM 211

Description : The normal serum level of triiodothyronine (T3) is (A) 0.2–0.5 ng/ml (B) 0.7–2.0 ng/ml (C) 2.0–4.0 ng/ml (D) 5.0–8.0 ng/ml HORMONE METABOLISM 211

Last Answer : Answer : B

The normal serum inorganic phosphorous level is (A) 1.5–2.5 mg/100 ml (B) 2.5–4.5 mg/100 ml (C) 4.5–6.5 mg/100 ml (D) 0.5–1.5 mg/100 ml

Description : The normal serum inorganic phosphorous level is (A) 1.5–2.5 mg/100 ml (B) 2.5–4.5 mg/100 ml (C) 4.5–6.5 mg/100 ml (D) 0.5–1.5 mg/100 ml

Last Answer : Answer : B

Serum level of chromium in healthy adult is about (A) 2-5 µg/100 ml (B) 6-20 µg/100 ml (C) 30-60 µg/100 ml (D) 50-100 µg/100 ml

Description : Serum level of chromium in healthy adult is about (A) 2-5 µg/100 ml (B) 6-20 µg/100 ml (C) 30-60 µg/100 ml (D) 50-100 µg/100 ml

Last Answer : Answer : B

Serum progesterone level during pregnancy is (A) < 12 ng/ml (B) > 12 ng/ml (C) < 20 ng/ml (D) >24 ng/ml

Description : Serum progesterone level during pregnancy is (A) < 12 ng/ml (B) > 12 ng/ml (C) < 20 ng/ml (D) >24 ng/ml

Last Answer : Answer : D

Normal serum insulin level varies between (A) 4–25 µU/ml (B) 25–50 µU/ml (C) 70–90 µU/ml (D) 100–120 µU /ml

Description : Normal serum insulin level varies between (A) 4–25 µU/ml (B) 25–50 µU/ml (C) 70–90 µU/ml (D) 100–120 µU /ml

Last Answer : Answer : A

The normal serum level of phosphorous in children varies from (A) 1–2 mg/100 ml (B) 2–3 mg/100 ml (C) 3–4 mg/100 ml (D) 4–7 mg/100 ml

Description : The normal serum level of phosphorous in children varies from (A) 1–2 mg/100 ml (B) 2–3 mg/100 ml (C) 3–4 mg/100 ml (D) 4–7 mg/100 ml

Last Answer : Answer : D

The following is true of topiramate except: A. It is a broad spectrum antiepileptic drug B. It inhibits the enzyme carbonic anhydrase C. It is used as add-on therapy in refractory partial seizures D. It is not effective in generalized tonic-clonic seizures

Description : The following is true of topiramate except: A. It is a broad spectrum antiepileptic drug B. It inhibits the enzyme carbonic anhydrase C. It is used as add-on therapy in refractory partial seizures D. It is not effective in generalized tonic-clonic seizures

Last Answer : D. It is not effective in generalized tonic-clonic seizures

The following statement(s) is/are true concerning initial microbiologic diagnostic techniques. a. Appropriate expeditious transport of specimens to the microbiology laboratory is essential for obtaining accurate clinical information b. The use of potassium hydroxide in preparing a specimen slide for light microscopy will be useful in identification of anaerobic bacteria c. Antibiotic sensitivity is determined by exposing the specific microorganism to varying amounts of antibiotic with the concentration of the antibiotic inhibiting growth referred to as the MIC (minimal inhibitory concentration) d. Serum levels of antimicrobial agents should achieve in excess of a 4-to 8-fold increase over the MIC to be considered clinically efficacious.

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Last Answer : Answer: a, c, d Because most surgical infections are polymicrobial, specimens should be cultured for aerobic and anaerobic bacteria, as well as fungi. Although aerobic and aerotolerant ... fold increase over MIC during the peak serum level have been demonstrated to be clinically efficacious

The total serum testosterone in adult women is (A) 0–5 ng/100 ml (B) 10–15 ng/100 ml (C) 20–80 ng/100 ml (D) 100–200 ng/100 ml

Description : The total serum testosterone in adult women is (A) 0–5 ng/100 ml (B) 10–15 ng/100 ml (C) 20–80 ng/100 ml (D) 100–200 ng/100 ml

Last Answer : Answer : C

The normal serum concentration of ceruloplasmin in mg/100 ml varies between (A) 5–10 (B) 10–20 (C) 25–43 (D) 50–100

Description : The normal serum concentration of ceruloplasmin in mg/100 ml varies between (A) 5–10 (B) 10–20 (C) 25–43 (D) 50–100

Last Answer : Answer : C

The normal serum concentration of vitamin A in mg/100 ml is (A) 5–10 (B) 15–60 (C) 100–150 (D) 0–5

Description : The normal serum concentration of vitamin A in mg/100 ml is (A) 5–10 (B) 15–60 (C) 100–150 (D) 0–5

Last Answer : Answer : B

An epileptic woman controlled by phenytoin therapy conceives. Which of the following measures is most appropriate: A. Medical termination of pregnancy B. Withdraw phenytoin therapy C. Gradually reduce phenytoin dose to the lowest effective level D. Substitute phenytoin with a combination of carbamazepine and sodium valproate

Description : An epileptic woman controlled by phenytoin therapy conceives. Which of the following measures is most appropriate: A. Medical termination of pregnancy B. Withdraw phenytoin therapy C. ... lowest effective level D. Substitute phenytoin with a combination of carbamazepine and sodium valproate

Last Answer : C. Gradually reduce phenytoin dose to the lowest effective level

Megaloblastic anaemia developing under the following condition is due entirely to folate deficiency not associated with vitamin B12 deficiency: A. Malnutrition B. Blind loop syndrome C. Phenytoin therapy D. Pregnancy

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Last Answer : C. Phenytoin therapy

Maximum endurance: a. Can be achieved in level unaccelerated flight with minimum fuel consumption b. Can be achieved by flying at the best rate of climb speed in straight and level flight c. Can be achieved in a steady climb d. Can be achieved by flying at the absolute ceiling

Description : Maximum endurance: a. Can be achieved in level unaccelerated flight with minimum fuel consumption b. Can be achieved by flying at the best rate of climb speed in straight and level flight c. Can be achieved in a steady climb d. Can be achieved by flying at the absolute ceiling

Last Answer : a. Can be achieved in level unaccelerated flight with minimum fuel consumption

Maximum endurance: a. Can be achieved in level unaccelerated flight with minimum fuel consumption b. Can be achieved by flying at the best rate of climb speed in straight and level flight c. Can be achieved in a steady climb d. Can be achieved by flying at the absolute ceiling

Description : Maximum endurance: a. Can be achieved in level unaccelerated flight with minimum fuel consumption b. Can be achieved by flying at the best rate of climb speed in straight and level flight c. Can be achieved in a steady climb d. Can be achieved by flying at the absolute ceiling

Last Answer : a. Can be achieved in level unaccelerated flight with minimum fuel consumption

Select the factor which indicates that withdrawal of the successfully used antiepileptic medication is likely to result in recurrence of seizures: A. Childhood epilepsy B. Partial seizures C. Treatment started soon after seizure onset D. Absence of EEG abnormality

Description : Select the factor which indicates that withdrawal of the successfully used antiepileptic medication is likely to result in recurrence of seizures: A. Childhood epilepsy B. Partial seizures C. Treatment started soon after seizure onset D. Absence of EEG abnormality

Last Answer : B. Partial seizures

Maximum permissible limit of mercury in human blood is __________ micrograms/100 c.c. (A) 1 (B) 7 (C) 19 (D) 82

Description : Maximum permissible limit of mercury in human blood is __________ micrograms/100 c.c. (A) 1 (B) 7 (C) 19 (D) 82

Last Answer : (B) 7

A 35 yr old pt she is on phenytoin since she was 29 due to partial epilipsy she didn’t have any attack since. She want to stop taking the drug due to facial hair growth: a. It is reasonable to stop it now b. Stop it after 6 months c. Stop after 10 years d. Don’t stop it

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Last Answer : a. It is reasonable to stop it now

Steady fluid flow occurs, when the derivative of flow variables satisfy the following condition. (A) ∂/∂s = 0 (B) ∂/∂t = 0 (C) ∂/∂s = constant (D) ∂/∂t = constant

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Last Answer : (B) ∂/∂t = 0

Characteristics of Vitamin D and its metabolites include which one of the following? (a) Act to decrease serum levels of calcium (b) Activation of their Vitamin D receptors increases cellular CAMP (c) Calcitriol is the major derivative responsible for increasing intestinal absorption of phosphate (d) Metabolites of Vitamin D increase renal excretion of calcium (e) Vitamin D deficiency results in Pager’s disease

Description : Characteristics of Vitamin D and its metabolites include which one of the following? (a) Act to decrease serum levels of calcium (b) Activation of their Vitamin D receptors increases cellular CAMP ... Vitamin D increase renal excretion of calcium (e) Vitamin D deficiency results in Pager's disease

Last Answer : Ans: C

The normal serum of concentration of copper in mg/100 ml varies between (A) 0–5 (B) 50–100 (C) 100–200 (D) 200–300

Description : The normal serum of concentration of copper in mg/100 ml varies between (A) 0–5 (B) 50–100 (C) 100–200 (D) 200–300

Last Answer : Answer : C

In rickets of the common low-phosphate variety, serum phosphate values may go as low as (A) 1–2 mg/100 ml (B) 2–3 mg/100 ml (C) 3–4 mg/100 ml (D) 4–5 mg/100 ml

Description : In rickets of the common low-phosphate variety, serum phosphate values may go as low as (A) 1–2 mg/100 ml (B) 2–3 mg/100 ml (C) 3–4 mg/100 ml (D) 4–5 mg/100 ml

Last Answer : Answer : A

The normal serum alkaline phosphatase activity ranges from (A) 1.0–5.0 KA units/100 ml (B) 5.0–13.0 KA units/100 ml (C) 0.8–2.3 KA units/100 ml (D) 13.0–21.0 KA units/100 ml

Description : The normal serum alkaline phosphatase activity ranges from (A) 1.0–5.0 KA units/100 ml (B) 5.0–13.0 KA units/100 ml (C) 0.8–2.3 KA units/100 ml (D) 13.0–21.0 KA units/100 ml

Last Answer : Answer : B

The normal serum acid phosphatase activity ranges from (A) 5.0–13.0 KA units/100 ml (B) 1.0–5.0 KA units/100 ml (C) 13.0–18.0 KA units/100 ml (D) 0.2–0.8 KA units/100 ml

Description : The normal serum acid phosphatase activity ranges from (A) 5.0–13.0 KA units/100 ml (B) 1.0–5.0 KA units/100 ml (C) 13.0–18.0 KA units/100 ml (D) 0.2–0.8 KA units/100 ml

Last Answer : Answer : B