Which of the following techniques would be most useful in the differential diagnosis between ectopic Cushing's syndrome and pituitary dependent Cushing's disease. 1) Urine free cortisol 2) High dose Dexamethasone suppression test 3) ACTH concentrations 4) Inferior petrosal sinus sampling 5) CRF test

Which of the following techniques would be most useful in the differential diagnosis between ectopic Cushing's syndrome and pituitary dependent Cushing's disease. 1) Urine free cortisol 2) High dose Dexamethasone suppression test 3) ACTH concentrations 4) Inferior petrosal sinus sampling 5) CRF test
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Answers-4 Inferior petrosal sinus sampling with an elevated central ACTH concentration compared with the peripheral value is the most valuable test in the differential diagnosis of either Cushing's disease or ectopic Cushing's syndrome. The other tests are far less useful in comparison.
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